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Protein

N-acylglucosamine 2-epimerase

Gene

Renbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.1 Publication

Catalytic activityi

N-acyl-D-glucosamine = N-acyl-D-mannosamine.1 Publication

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

GO - Molecular functioni

GO - Biological processi

  • N-acetylglucosamine metabolic process Source: MGI
  • N-acetylmannosamine metabolic process Source: Ensembl
  • N-acetylneuraminate catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiR-MMU-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylglucosamine 2-epimerase (EC:5.1.3.8)
Short name:
AGE
Alternative name(s):
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
Short name:
RnBP
Gene namesi
Name:Renbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:105940. Renbp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430N-acylglucosamine 2-epimerasePRO_0000208950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei429 – 4291PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP82343.
PaxDbiP82343.
PeptideAtlasiP82343.
PRIDEiP82343.

PTM databases

iPTMnetiP82343.
PhosphoSiteiP82343.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031387.
CleanExiMM_RENBP.
ExpressionAtlasiP82343. baseline and differential.
GenevisibleiP82343. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112277.

Structurei

3D structure databases

ProteinModelPortaliP82343.
SMRiP82343. Positions 12-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 21722Leucine-zipperAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE08. Eukaryota.
COG2942. LUCA.
GeneTreeiENSGT00390000013740.
HOGENOMiHOG000252296.
HOVERGENiHBG054048.
InParanoidiP82343.
KOiK01787.
OMAiPMMLLNL.
OrthoDBiEOG091G0EO8.
PhylomeDBiP82343.
TreeFamiTF329027.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P82343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDLGLLMLQ DMEKERETLQ VWKKRVEQEL DRVIAFWMEH SHDQEHGGFF
60 70 80 90 100
TCLGRDGKVY DHLKYVWLQG RQVWMYCRLY RSFERFRRVE LLDAARAGGE
110 120 130 140 150
FLLRYARVAP PGKKCAFVLT RDGRPVKVQR TIFSECFYTM AMNELWKVTG
160 170 180 190 200
EVRYQSEAIE MMDQIIHWVR EDPAGLGRPQ LSGALATEPM AVPMMLLSLV
210 220 230 240 250
EQLGEEDEEL TNMYAELGDW CVHRILQHVQ RDGQVVLENV SEDGKELPGC
260 270 280 290 300
LGRHQNPGHT LEAGWFLLQY ALRKGDPKLR MHIIDKFLLL PFHSGWDPEH
310 320 330 340 350
GGLFYFQDAD GLCPTQLEWN MKLWWPHSEA MIAFLMGYSD SGDPALLHLF
360 370 380 390 400
YKVAEYTFRQ FRDPEYGEWF GYLNQEGKVA LTIKGGPFKG CFHVPRCLAM
410 420 430
CEQILGALLQ RLEPAPLDSS PAVSTHEGSK
Length:430
Mass (Da):49,771
Last modified:April 20, 2010 - v3
Checksum:iAC02782E9860BC77
GO
Isoform 2 (identifier: P82343-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-72: Missing.

Show »
Length:416
Mass (Da):47,984
Checksum:i91295AA582837718
GO

Sequence cautioni

The sequence AAH14821 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO66340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB29288 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1782GR → AV in BAB29288 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei59 – 7214Missing in isoform 2. 2 PublicationsVSP_039024Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133093 Genomic DNA. No translation available.
AY183138 mRNA. Translation: AAO66340.1. Different initiation.
AK014347 mRNA. Translation: BAB29288.1. Different initiation.
AK146652 mRNA. Translation: BAE27332.1.
AK167648 mRNA. Translation: BAE39699.1.
AL672002 Genomic DNA. Translation: CAM18723.1.
AL672002 Genomic DNA. Translation: CAM18724.1.
CH466650 Genomic DNA. Translation: EDL29852.1.
CH466650 Genomic DNA. Translation: EDL29854.1.
BC014821 mRNA. Translation: AAH14821.1. Different initiation.
CCDSiCCDS41015.2. [P82343-1]
CCDS57763.1. [P82343-2]
RefSeqiNP_001158176.1. NM_001164704.1. [P82343-2]
NP_075621.3. NM_023132.3. [P82343-1]
UniGeneiMm.236969.

Genome annotation databases

EnsembliENSMUST00000114379; ENSMUSP00000110020; ENSMUSG00000031387. [P82343-2]
ENSMUST00000116578; ENSMUSP00000112277; ENSMUSG00000031387. [P82343-1]
GeneIDi19703.
KEGGimmu:19703.
UCSCiuc009tnj.2. mouse. [P82343-1]
uc009tnk.2. mouse. [P82343-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133093 Genomic DNA. No translation available.
AY183138 mRNA. Translation: AAO66340.1. Different initiation.
AK014347 mRNA. Translation: BAB29288.1. Different initiation.
AK146652 mRNA. Translation: BAE27332.1.
AK167648 mRNA. Translation: BAE39699.1.
AL672002 Genomic DNA. Translation: CAM18723.1.
AL672002 Genomic DNA. Translation: CAM18724.1.
CH466650 Genomic DNA. Translation: EDL29852.1.
CH466650 Genomic DNA. Translation: EDL29854.1.
BC014821 mRNA. Translation: AAH14821.1. Different initiation.
CCDSiCCDS41015.2. [P82343-1]
CCDS57763.1. [P82343-2]
RefSeqiNP_001158176.1. NM_001164704.1. [P82343-2]
NP_075621.3. NM_023132.3. [P82343-1]
UniGeneiMm.236969.

3D structure databases

ProteinModelPortaliP82343.
SMRiP82343. Positions 12-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112277.

PTM databases

iPTMnetiP82343.
PhosphoSiteiP82343.

Proteomic databases

MaxQBiP82343.
PaxDbiP82343.
PeptideAtlasiP82343.
PRIDEiP82343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114379; ENSMUSP00000110020; ENSMUSG00000031387. [P82343-2]
ENSMUST00000116578; ENSMUSP00000112277; ENSMUSG00000031387. [P82343-1]
GeneIDi19703.
KEGGimmu:19703.
UCSCiuc009tnj.2. mouse. [P82343-1]
uc009tnk.2. mouse. [P82343-2]

Organism-specific databases

CTDi5973.
MGIiMGI:105940. Renbp.

Phylogenomic databases

eggNOGiENOG410IE08. Eukaryota.
COG2942. LUCA.
GeneTreeiENSGT00390000013740.
HOGENOMiHOG000252296.
HOVERGENiHBG054048.
InParanoidiP82343.
KOiK01787.
OMAiPMMLLNL.
OrthoDBiEOG091G0EO8.
PhylomeDBiP82343.
TreeFamiTF329027.

Enzyme and pathway databases

UniPathwayiUPA00629.
ReactomeiR-MMU-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

ChiTaRSiRenbp. mouse.
PROiP82343.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031387.
CleanExiMM_RENBP.
ExpressionAtlasiP82343. baseline and differential.
GenevisibleiP82343. MM.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRENBP_MOUSE
AccessioniPrimary (citable) accession number: P82343
Secondary accession number(s): Q3TIZ6
, Q3UJ23, Q80Z67, Q91WI9, Q9CXI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-2, Met-8 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.