ID   DEF6_MACMU              Reviewed;          94 AA.
AC   P82320;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-MAR-2009, entry version 49.
DE   RecName: Full=Neutrophil defensin 6;
DE   AltName: Full=RMAD-6;
DE   Contains:
DE     RecName: Full=Neutrophil defensin 7;
DE     AltName: Full=RMAD-7;
DE   Flags: Precursor;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 62-94, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Bone marrow, and Leukocyte;
RX   MEDLINE=20002603; PubMed=10531277;
RA   Tang Y.Q., Yuan J., Miller C.J., Selsted M.E.;
RT   "Isolation, characterization, cDNA cloning, and antimicrobial
RT   properties of two distinct subfamilies of alpha-defensins from rhesus
RT   macaque leukocytes.";
RL   Infect. Immun. 67:6139-6144(1999).
CC   -!- FUNCTION: Defensins 6 and 7 have bacteriostatic activity against
CC       Gram-positive bacteria S.aureus and L.monocytogenes and Gram-
CC       negative bacterium E.coli and antifungal activity against
CC       C.neoformans. Defensin 7 has microbicidial activity against Gram-
CC       positive bacteria S.aureus and L.monocytogenes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=3898.0; Method=MALDI; Range=62-94;
CC       Source=PubMed:10531277;
CC   -!- MASS SPECTROMETRY: Mass=3740.0; Method=MALDI; Range=63-94;
CC       Source=PubMed:10531277;
CC   -!- SIMILARITY: Belongs to the alpha-defensin family.
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DR   EMBL; AF188272; AAF06316.1; -; mRNA.
DR   PIR; F59076; F59076.
DR   PIR; G59076; G59076.
DR   UniGene; Mmu.3478; -.
DR   Ensembl; ENSMMUG00000017957; Macaca mulatta.
DR   HOVERGEN; P82320; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Defensin_alpha.
DR   InterPro; IPR006080; Defensin_mammal.
DR   InterPro; IPR002366; Defensin_propep.
DR   Pfam; PF00323; Defensin_1; 1.
DR   Pfam; PF00879; Defensin_propep; 1.
DR   PIRSF; PIRSF001875; Alpha-defensin; 1.
DR   SMART; SM00048; DEFSN; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Fungicide; Secreted; Signal.
FT   SIGNAL        1     19       Potential.
FT   PROPEP       20     61
FT                                /FTId=PRO_0000006802.
FT   PEPTIDE      62     94       Neutrophil defensin 6.
FT                                /FTId=PRO_0000006803.
FT   PEPTIDE      63     94       Neutrophil defensin 7.
FT                                /FTId=PRO_0000006804.
FT   DISULFID     65     92       By similarity.
FT   DISULFID     67     82       By similarity.
FT   DISULFID     72     93       By similarity.
SQ   SEQUENCE   94 AA;  10307 MW;  E06932080A06CCD2 CRC64;
     MRTIAILAAI LLFALLAQAK SLQETADEAA TQEQPGEDDQ DLAVSFEENG LSTLRASGSQ
     ARRTCRCRFG RCFRRESYSG SCNINGRISS LCCR
//