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Protein

Neutrophil defensin 6

Gene
N/A
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Defensins 6 and 7 have bacteriostatic activity against Gram-positive bacteria S.aureus and L.monocytogenes and Gram-negative bacterium E.coli and antifungal activity against C.neoformans. Defensin 7 has microbicidial activity against Gram-positive bacteria S.aureus and L.monocytogenes.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil defensin 6
Alternative name(s):
RMAD-6
Cleaved into the following chain:
Alternative name(s):
RMAD-7
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 61421 PublicationPRO_0000006802Add
BLAST
Peptidei62 – 9433Neutrophil defensin 6PRO_0000006803Add
BLAST
Peptidei63 – 9432Neutrophil defensin 7PRO_0000006804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP82320.
SMRiP82320. Positions 64-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG011703.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIAILAAI LLFALLAQAK SLQETADEAA TQEQPGEDDQ DLAVSFEENG
60 70 80 90
LSTLRASGSQ ARRTCRCRFG RCFRRESYSG SCNINGRISS LCCR
Length:94
Mass (Da):10,307
Last modified:May 1, 2000 - v1
Checksum:iE06932080A06CCD2
GO

Mass spectrometryi

Molecular mass is 3898.0 Da from positions 62 - 94. Determined by MALDI. 1 Publication
Molecular mass is 3740.0 Da from positions 63 - 94. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188272 mRNA. Translation: AAF06316.1.
PIRiF59076.
G59076.
UniGeneiMmu.3478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188272 mRNA. Translation: AAF06316.1.
PIRiF59076.
G59076.
UniGeneiMmu.3478.

3D structure databases

ProteinModelPortaliP82320.
SMRiP82320. Positions 64-94.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG011703.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEF6_MACMU
AccessioniPrimary (citable) accession number: P82320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.