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P82252

- BAT1_RAT

UniProt

P82252 - BAT1_RAT

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Protein

b(0,+)-type amino acid transporter 1

Gene

Slc7a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule.1 Publication

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: RGD
  2. neutral amino acid transmembrane transporter activity Source: UniProtKB
  3. peptide antigen binding Source: UniProtKB

GO - Biological processi

  1. amino acid transport Source: RGD
  2. neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_243822. Amino acid transport across the plasma membrane.
REACT_245266. Basigin interactions.

Protein family/group databases

TCDBi2.A.3.8.15. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
b(0,+)-type amino acid transporter 1
Short name:
b(0,+)AT
Alternative name(s):
Glycoprotein-associated amino acid transporter b0,+AT1
Solute carrier family 7 member 9
Gene namesi
Name:Slc7a9
Synonyms:Bat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi619905. Slc7a9.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Topological domaini51 – 6313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Topological domaini85 – 9915CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Topological domaini121 – 1233ExtracellularSequence Analysis
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Topological domaini145 – 1473CytoplasmicSequence Analysis
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Topological domaini169 – 17810ExtracellularSequence Analysis
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Topological domaini200 – 25455CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 29621ExtracellularSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST
Topological domaini318 – 34831CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence AnalysisAdd
BLAST
Topological domaini370 – 3745ExtracellularSequence Analysis
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Topological domaini396 – 40914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Topological domaini431 – 4344ExtracellularSequence Analysis
Transmembranei435 – 45521HelicalSequence AnalysisAdd
BLAST
Topological domaini456 – 48732CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487b(0,+)-type amino acid transporter 1PRO_0000054260Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP82252.

Expressioni

Tissue specificityi

Outer medulla of kidney (at protein level). Kidney and small intestine. In the kidney localized to the apical membrane of the proximal tubules.2 Publications

Gene expression databases

GenevestigatoriP82252.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A1. Interacts with CAV1.2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016919.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiP82252.
KOiK13868.
OMAiSFSEYVC.
OrthoDBiEOG73BVCR.
PhylomeDBiP82252.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P82252-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEETSPRRRR EDEKSVHSTE PKTTSLQKEV GLLSGICIIV GTIIGSGIFI
60 70 80 90 100
SPKSVLANTE SVGPCLIIWA ACGVLATLGA LCFAELGTMI TKSGGEYPYL
110 120 130 140 150
MEAFGPIPAY LFSWTSLIVM KPSSFAIICL SFSEYVCAAF YLGCRPPAVV
160 170 180 190 200
VKLLAAAAIL LITTVNALSV RLGSYVQNVF TAAKLVIVAI IIISGLVLLA
210 220 230 240 250
QGNVKNFQNS FEGSQTSVGS ISLAFYNGLW AYDGWNQLNY ITEELRNPYR
260 270 280 290 300
NLPMAIVIGI PLVTVCYILM NIAYFTVMTP TELLQSQAVA VTFGDRVLYP
310 320 330 340 350
ASWVVPLFVA FSTIGAANGT CFTAGRLIYV AGREGHMLKV LSYISVKRLT
360 370 380 390 400
PAPALVFYGI IAIIYIIPGD INSLVNYFSF AAWLFYGMTI LGLVVMRFTR
410 420 430 440 450
KDLERPIKVP IFIPIIVILV SVFLILAPII SSPAWEYLYC VLFILSGLIF
460 470 480
YFLFVHYKFR WAQKISRPIT KHLQMLMEVV PPEKDPE
Length:487
Mass (Da):53,658
Last modified:May 1, 2000 - v1
Checksum:iEB43AA1FCC8DC3A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029559 mRNA. Translation: BAA85186.1.
BC098909 mRNA. Translation: AAH98909.1.
RefSeqiNP_446381.1. NM_053929.1.
XP_006228937.1. XM_006228875.2.
XP_006228938.1. XM_006228876.2.
XP_006228939.1. XM_006228877.2.
XP_008757325.1. XM_008759103.1.
XP_008757326.1. XM_008759104.1.
UniGeneiRn.32225.

Genome annotation databases

EnsembliENSRNOT00000016919; ENSRNOP00000016919; ENSRNOG00000012344.
GeneIDi116726.
KEGGirno:116726.
UCSCiRGD:619905. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029559 mRNA. Translation: BAA85186.1 .
BC098909 mRNA. Translation: AAH98909.1 .
RefSeqi NP_446381.1. NM_053929.1.
XP_006228937.1. XM_006228875.2.
XP_006228938.1. XM_006228876.2.
XP_006228939.1. XM_006228877.2.
XP_008757325.1. XM_008759103.1.
XP_008757326.1. XM_008759104.1.
UniGenei Rn.32225.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016919.

Protein family/group databases

TCDBi 2.A.3.8.15. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEi P82252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016919 ; ENSRNOP00000016919 ; ENSRNOG00000012344 .
GeneIDi 116726.
KEGGi rno:116726.
UCSCi RGD:619905. rat.

Organism-specific databases

CTDi 11136.
RGDi 619905. Slc7a9.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119037.
HOGENOMi HOG000098892.
HOVERGENi HBG000476.
InParanoidi P82252.
KOi K13868.
OMAi SFSEYVC.
OrthoDBi EOG73BVCR.
PhylomeDBi P82252.
TreeFami TF313355.

Enzyme and pathway databases

Reactomei REACT_243822. Amino acid transport across the plasma membrane.
REACT_245266. Basigin interactions.

Miscellaneous databases

NextBioi 619654.
PROi P82252.

Gene expression databases

Genevestigatori P82252.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein."
    Chairoungdua A., Segawa H., Kim J.Y., Miyamoto K., Haga H., Fukui Y., Mizoguchi K., Ito H., Takeda E., Endou H., Kanai Y.
    J. Biol. Chem. 274:28845-28848(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
    Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
    J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CAV1.

Entry informationi

Entry nameiBAT1_RAT
AccessioniPrimary (citable) accession number: P82252
Secondary accession number(s): Q4KM04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3