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P82252 (BAT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
b(0,+)-type amino acid transporter 1

Short name=b(0,+)AT
Alternative name(s):
Glycoprotein-associated amino acid transporter b0,+AT1
Solute carrier family 7 member 9
Gene names
Name:Slc7a9
Synonyms:Bat1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule. Ref.1

Subunit structure

Disulfide-linked heterodimer with the amino acid transport protein SLC3A1. Interacts with CAV1. Ref.1 Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1 Ref.3.

Tissue specificity

Outer medulla of kidney (at protein level). Kidney and small intestine. In the kidney localized to the apical membrane of the proximal tubules. Ref.1 Ref.3

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487b(0,+)-type amino acid transporter 1
PRO_0000054260

Regions

Topological domain1 – 2929Cytoplasmic Potential
Transmembrane30 – 5021Helical; Potential
Topological domain51 – 6313Extracellular Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 9915Cytoplasmic Potential
Transmembrane100 – 12021Helical; Potential
Topological domain121 – 1233Extracellular Potential
Transmembrane124 – 14421Helical; Potential
Topological domain145 – 1473Cytoplasmic Potential
Transmembrane148 – 16821Helical; Potential
Topological domain169 – 17810Extracellular Potential
Transmembrane179 – 19921Helical; Potential
Topological domain200 – 25455Cytoplasmic Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 29621Extracellular Potential
Transmembrane297 – 31721Helical; Potential
Topological domain318 – 34831Cytoplasmic Potential
Transmembrane349 – 36921Helical; Potential
Topological domain370 – 3745Extracellular Potential
Transmembrane375 – 39521Helical; Potential
Topological domain396 – 40914Cytoplasmic Potential
Transmembrane410 – 43021Helical; Potential
Topological domain431 – 4344Extracellular Potential
Transmembrane435 – 45521Helical; Potential
Topological domain456 – 48732Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P82252 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: EB43AA1FCC8DC3A7

FASTA48753,658
        10         20         30         40         50         60 
MEETSPRRRR EDEKSVHSTE PKTTSLQKEV GLLSGICIIV GTIIGSGIFI SPKSVLANTE 

        70         80         90        100        110        120 
SVGPCLIIWA ACGVLATLGA LCFAELGTMI TKSGGEYPYL MEAFGPIPAY LFSWTSLIVM 

       130        140        150        160        170        180 
KPSSFAIICL SFSEYVCAAF YLGCRPPAVV VKLLAAAAIL LITTVNALSV RLGSYVQNVF 

       190        200        210        220        230        240 
TAAKLVIVAI IIISGLVLLA QGNVKNFQNS FEGSQTSVGS ISLAFYNGLW AYDGWNQLNY 

       250        260        270        280        290        300 
ITEELRNPYR NLPMAIVIGI PLVTVCYILM NIAYFTVMTP TELLQSQAVA VTFGDRVLYP 

       310        320        330        340        350        360 
ASWVVPLFVA FSTIGAANGT CFTAGRLIYV AGREGHMLKV LSYISVKRLT PAPALVFYGI 

       370        380        390        400        410        420 
IAIIYIIPGD INSLVNYFSF AAWLFYGMTI LGLVVMRFTR KDLERPIKVP IFIPIIVILV 

       430        440        450        460        470        480 
SVFLILAPII SSPAWEYLYC VLFILSGLIF YFLFVHYKFR WAQKISRPIT KHLQMLMEVV 


PPEKDPE 

« Hide

References

« Hide 'large scale' references
[1]"Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein."
Chairoungdua A., Segawa H., Kim J.Y., Miyamoto K., Haga H., Fukui Y., Mizoguchi K., Ito H., Takeda E., Endou H., Kanai Y.
J. Biol. Chem. 274:28845-28848(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CAV1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029559 mRNA. Translation: BAA85186.1.
BC098909 mRNA. Translation: AAH98909.1.
RefSeqNP_446381.1. NM_053929.1.
XP_006228937.1. XM_006228875.1.
XP_006228938.1. XM_006228876.1.
XP_006228939.1. XM_006228877.1.
UniGeneRn.32225.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016919.

Protein family/group databases

TCDB2.A.3.8.15. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEP82252.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016919; ENSRNOP00000016919; ENSRNOG00000012344.
GeneID116726.
KEGGrno:116726.
UCSCRGD:619905. rat.

Organism-specific databases

CTD11136.
RGD619905. Slc7a9.

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00730000110456.
HOGENOMHOG000098892.
HOVERGENHBG000476.
InParanoidP82252.
KOK13868.
OMAITMHLQM.
OrthoDBEOG73BVCR.
PhylomeDBP82252.
TreeFamTF313355.

Gene expression databases

GenevestigatorP82252.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

NextBio619654.
PROP82252.

Entry information

Entry nameBAT1_RAT
AccessionPrimary (citable) accession number: P82252
Secondary accession number(s): Q4KM04
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families