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P82252

- BAT1_RAT

UniProt

P82252 - BAT1_RAT

Protein

b(0,+)-type amino acid transporter 1

Gene

Slc7a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule.1 Publication

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: RGD
    2. neutral amino acid transmembrane transporter activity Source: UniProtKB
    3. peptide antigen binding Source: UniProtKB

    GO - Biological processi

    1. amino acid transport Source: RGD
    2. neutral amino acid transport Source: UniProtKB

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.8.15. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    b(0,+)-type amino acid transporter 1
    Short name:
    b(0,+)AT
    Alternative name(s):
    Glycoprotein-associated amino acid transporter b0,+AT1
    Solute carrier family 7 member 9
    Gene namesi
    Name:Slc7a9
    Synonyms:Bat1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi619905. Slc7a9.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. brush border membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487b(0,+)-type amino acid transporter 1PRO_0000054260Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP82252.

    Expressioni

    Tissue specificityi

    Outer medulla of kidney (at protein level). Kidney and small intestine. In the kidney localized to the apical membrane of the proximal tubules.2 Publications

    Gene expression databases

    GenevestigatoriP82252.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A1. Interacts with CAV1.2 Publications

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016919.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 9915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini121 – 1233ExtracellularSequence Analysis
    Topological domaini145 – 1473CytoplasmicSequence Analysis
    Topological domaini169 – 17810ExtracellularSequence Analysis
    Topological domaini200 – 25455CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini276 – 29621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 34831CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini370 – 3745ExtracellularSequence Analysis
    Topological domaini396 – 40914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 4344ExtracellularSequence Analysis
    Topological domaini456 – 48732CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei349 – 36921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00730000110456.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiP82252.
    KOiK13868.
    OMAiSFSEYVC.
    OrthoDBiEOG73BVCR.
    PhylomeDBiP82252.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P82252-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEETSPRRRR EDEKSVHSTE PKTTSLQKEV GLLSGICIIV GTIIGSGIFI    50
    SPKSVLANTE SVGPCLIIWA ACGVLATLGA LCFAELGTMI TKSGGEYPYL 100
    MEAFGPIPAY LFSWTSLIVM KPSSFAIICL SFSEYVCAAF YLGCRPPAVV 150
    VKLLAAAAIL LITTVNALSV RLGSYVQNVF TAAKLVIVAI IIISGLVLLA 200
    QGNVKNFQNS FEGSQTSVGS ISLAFYNGLW AYDGWNQLNY ITEELRNPYR 250
    NLPMAIVIGI PLVTVCYILM NIAYFTVMTP TELLQSQAVA VTFGDRVLYP 300
    ASWVVPLFVA FSTIGAANGT CFTAGRLIYV AGREGHMLKV LSYISVKRLT 350
    PAPALVFYGI IAIIYIIPGD INSLVNYFSF AAWLFYGMTI LGLVVMRFTR 400
    KDLERPIKVP IFIPIIVILV SVFLILAPII SSPAWEYLYC VLFILSGLIF 450
    YFLFVHYKFR WAQKISRPIT KHLQMLMEVV PPEKDPE 487
    Length:487
    Mass (Da):53,658
    Last modified:May 1, 2000 - v1
    Checksum:iEB43AA1FCC8DC3A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029559 mRNA. Translation: BAA85186.1.
    BC098909 mRNA. Translation: AAH98909.1.
    RefSeqiNP_446381.1. NM_053929.1.
    XP_006228937.1. XM_006228875.1.
    XP_006228938.1. XM_006228876.1.
    XP_006228939.1. XM_006228877.1.
    UniGeneiRn.32225.

    Genome annotation databases

    EnsembliENSRNOT00000016919; ENSRNOP00000016919; ENSRNOG00000012344.
    GeneIDi116726.
    KEGGirno:116726.
    UCSCiRGD:619905. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029559 mRNA. Translation: BAA85186.1 .
    BC098909 mRNA. Translation: AAH98909.1 .
    RefSeqi NP_446381.1. NM_053929.1.
    XP_006228937.1. XM_006228875.1.
    XP_006228938.1. XM_006228876.1.
    XP_006228939.1. XM_006228877.1.
    UniGenei Rn.32225.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016919.

    Protein family/group databases

    TCDBi 2.A.3.8.15. the amino acid-polyamine-organocation (apc) family.

    Proteomic databases

    PRIDEi P82252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016919 ; ENSRNOP00000016919 ; ENSRNOG00000012344 .
    GeneIDi 116726.
    KEGGi rno:116726.
    UCSCi RGD:619905. rat.

    Organism-specific databases

    CTDi 11136.
    RGDi 619905. Slc7a9.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00730000110456.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi P82252.
    KOi K13868.
    OMAi SFSEYVC.
    OrthoDBi EOG73BVCR.
    PhylomeDBi P82252.
    TreeFami TF313355.

    Miscellaneous databases

    NextBioi 619654.
    PROi P82252.

    Gene expression databases

    Genevestigatori P82252.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein."
      Chairoungdua A., Segawa H., Kim J.Y., Miyamoto K., Haga H., Fukui Y., Mizoguchi K., Ito H., Takeda E., Endou H., Kanai Y.
      J. Biol. Chem. 274:28845-28848(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
      Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
      J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CAV1.

    Entry informationi

    Entry nameiBAT1_RAT
    AccessioniPrimary (citable) accession number: P82252
    Secondary accession number(s): Q4KM04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3