Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P82242

- PLAL1_PLALA

UniProt

P82242 - PLAL1_PLALA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Major pollen allergen Pla l 1

Gene
N/A
Organism
Plantago lanceolata (English plantain) (Ribwort plantain)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Pla l 1
Alternative name(s):
Allergen: Pla l 1
OrganismiPlantago lanceolata (English plantain) (Ribwort plantain)
Taxonomic identifieri39414 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaePlantagineaePlantago

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. The English plantain pollen is an important cause of pollinosis in the temperate regions of North America, Australia and Europe. The glycan moiety does not seem to constitute a relevant allergenic epitope.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1323. Pla l 1.0101.
1324. Pla l 1.0102.
1325. Pla l 1.0103.
574. Pla l 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Major pollen allergen Pla l 1PRO_0000215117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi17 ↔ 86By similarity
Disulfide bondi20 ↔ 131By similarity
Disulfide bondi42 ↔ 74By similarity
Glycosylationi107 – 1071N-linked (GlcNAc...)Curated

Post-translational modificationi

Exists in two variants: glycosylated and non-glycosylated. Carries a complex, major N-linked glycan, with a alpha-1,3-fucose residue in its structure and probably also a beta-1,2-xylose. The average modification of molecular mass due to glycosylation is approximately 969 Da.
There are probably three disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the Ole e I family.Curated

Family and domain databases

InterProiIPR006041. Pollen_Ole_e1_allergen.
[Graphical view]
PfamiPF01190. Pollen_Ole_e_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82242-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TQTSHPAKFH VEGEVYCNVC HSRNLINELS ERMAGAQVQL DCKDDSKKVI
60 70 80 90 100
YSIGGETDQD GVYRLPVVGY HEDCEIKLVK SSRPDCSEIP KLAKGTIQTS
110 120 130
KVDLSKNTTI TEKTRHVKPL SFRAKTDAPG C
Length:131
Mass (Da):14,521
Last modified:February 12, 2003 - v2
Checksum:i62F9B279ED3A4BC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581D → G in Pla l 1.0102 and 1.0103.
Natural varianti82 – 821S → G in Pla l 1.0103.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313166 mRNA. Translation: CAC41633.1.
AJ313167 mRNA. Translation: CAC41634.1.
AJ313168 mRNA. Translation: CAC41635.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313166 mRNA. Translation: CAC41633.1 .
AJ313167 mRNA. Translation: CAC41634.1 .
AJ313168 mRNA. Translation: CAC41635.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 1323. Pla l 1.0101.
1324. Pla l 1.0102.
1325. Pla l 1.0103.
574. Pla l 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR006041. Pollen_Ole_e1_allergen.
[Graphical view ]
Pfami PF01190. Pollen_Ole_e_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of biologically active Plantago lanceolata pollen allergen Pla l 1 in the yeast Pichia pastoris."
    Calabozo B., Diaz-Perales A., Salcedo G., Barber D., Polo F.
    Biochem. J. 372:889-896(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.
  2. "Purification and characterization of the main allergen of Plantago lanceolata pollen, Pla l 1."
    Calabozo B., Barber D., Polo F.
    Clin. Exp. Allergy 31:322-330(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-18.
    Tissue: Pollen.
  3. "Studies on the carbohydrate moiety of Pla l 1 allergen. Identification of a major N-glycan and significance for the immunoglobulin E-binding activity."
    Calabozo B., Barber D., Polo F.
    Clin. Exp. Allergy 32:1628-1634(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE OF CARBOHYDRATE.

Entry informationi

Entry nameiPLAL1_PLALA
AccessioniPrimary (citable) accession number: P82242
Secondary accession number(s): Q93X26, Q949A3, Q949A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: October 29, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3