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P82242

- PLAL1_PLALA

UniProt

P82242 - PLAL1_PLALA

Protein

Major pollen allergen Pla l 1

Gene
N/A
Organism
Plantago lanceolata (English plantain) (Ribwort plantain)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major pollen allergen Pla l 1
    Alternative name(s):
    Allergen: Pla l 1
    OrganismiPlantago lanceolata (English plantain) (Ribwort plantain)
    Taxonomic identifieri39414 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaePlantagineaePlantago

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE. The English plantain pollen is an important cause of pollinosis in the temperate regions of North America, Australia and Europe. The glycan moiety does not seem to constitute a relevant allergenic epitope.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei1323. Pla l 1.0101.
    1324. Pla l 1.0102.
    1325. Pla l 1.0103.
    574. Pla l 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 131131Major pollen allergen Pla l 1PRO_0000215117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi17 ↔ 86By similarity
    Disulfide bondi20 ↔ 131By similarity
    Disulfide bondi42 ↔ 74By similarity
    Glycosylationi107 – 1071N-linked (GlcNAc...)Curated

    Post-translational modificationi

    Exists in two variants: glycosylated and non-glycosylated. Carries a complex, major N-linked glycan, with a alpha-1,3-fucose residue in its structure and probably also a beta-1,2-xylose. The average modification of molecular mass due to glycosylation is approximately 969 Da.
    There are probably three disulfide bonds.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Ole e I family.Curated

    Family and domain databases

    InterProiIPR006041. Pollen_Ole_e1_allergen.
    [Graphical view]
    PfamiPF01190. Pollen_Ole_e_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82242-1 [UniParc]FASTAAdd to Basket

    « Hide

    TQTSHPAKFH VEGEVYCNVC HSRNLINELS ERMAGAQVQL DCKDDSKKVI    50
    YSIGGETDQD GVYRLPVVGY HEDCEIKLVK SSRPDCSEIP KLAKGTIQTS 100
    KVDLSKNTTI TEKTRHVKPL SFRAKTDAPG C 131
    Length:131
    Mass (Da):14,521
    Last modified:February 12, 2003 - v2
    Checksum:i62F9B279ED3A4BC6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581D → G in Pla l 1.0102 and 1.0103.
    Natural varianti82 – 821S → G in Pla l 1.0103.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313166 mRNA. Translation: CAC41633.1.
    AJ313167 mRNA. Translation: CAC41634.1.
    AJ313168 mRNA. Translation: CAC41635.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313166 mRNA. Translation: CAC41633.1 .
    AJ313167 mRNA. Translation: CAC41634.1 .
    AJ313168 mRNA. Translation: CAC41635.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1323. Pla l 1.0101.
    1324. Pla l 1.0102.
    1325. Pla l 1.0103.
    574. Pla l 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR006041. Pollen_Ole_e1_allergen.
    [Graphical view ]
    Pfami PF01190. Pollen_Ole_e_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of biologically active Plantago lanceolata pollen allergen Pla l 1 in the yeast Pichia pastoris."
      Calabozo B., Diaz-Perales A., Salcedo G., Barber D., Polo F.
      Biochem. J. 372:889-896(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.
    2. "Purification and characterization of the main allergen of Plantago lanceolata pollen, Pla l 1."
      Calabozo B., Barber D., Polo F.
      Clin. Exp. Allergy 31:322-330(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-18.
      Tissue: Pollen.
    3. "Studies on the carbohydrate moiety of Pla l 1 allergen. Identification of a major N-glycan and significance for the immunoglobulin E-binding activity."
      Calabozo B., Barber D., Polo F.
      Clin. Exp. Allergy 32:1628-1634(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE OF CARBOHYDRATE.

    Entry informationi

    Entry nameiPLAL1_PLALA
    AccessioniPrimary (citable) accession number: P82242
    Secondary accession number(s): Q93X26, Q949A3, Q949A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: February 12, 2003
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3