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P82242 (PLAL1_PLALA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major pollen allergen Pla l 1
Alternative name(s):
Allergen=Pla l 1
OrganismPlantago lanceolata (English plantain) (Ribwort plantain)
Taxonomic identifier39414 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaePlantagineaePlantago

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Post-translational modification

Exists in two variants: glycosylated and non-glycosylated. Carries a complex, major N-linked glycan, with a alpha-1,3-fucose residue in its structure and probably also a beta-1,2-xylose. The average modification of molecular mass due to glycosylation is approximately 969 Da. Ref.3

There are probably three disulfide bonds By similarity.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. The English plantain pollen is an important cause of pollinosis in the temperate regions of North America, Australia and Europe. The glycan moiety does not seem to constitute a relevant allergenic epitope.

Sequence similarities

Belongs to the Ole e I family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseAllergen
   PTMDisulfide bond
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Major pollen allergen Pla l 1
PRO_0000215117

Amino acid modifications

Glycosylation1071N-linked (GlcNAc...) Probable
Disulfide bond17 ↔ 86 By similarity
Disulfide bond20 ↔ 131 By similarity
Disulfide bond42 ↔ 74 By similarity

Natural variations

Natural variant581D → G in Pla l 1.0102 and 1.0103.
Natural variant821S → G in Pla l 1.0103.

Sequences

Sequence LengthMass (Da)Tools
P82242 [UniParc].

Last modified February 12, 2003. Version 2.
Checksum: 62F9B279ED3A4BC6

FASTA13114,521
        10         20         30         40         50         60 
TQTSHPAKFH VEGEVYCNVC HSRNLINELS ERMAGAQVQL DCKDDSKKVI YSIGGETDQD 

        70         80         90        100        110        120 
GVYRLPVVGY HEDCEIKLVK SSRPDCSEIP KLAKGTIQTS KVDLSKNTTI TEKTRHVKPL 

       130 
SFRAKTDAPG C 

« Hide

References

[1]"Cloning and expression of biologically active Plantago lanceolata pollen allergen Pla l 1 in the yeast Pichia pastoris."
Calabozo B., Diaz-Perales A., Salcedo G., Barber D., Polo F.
Biochem. J. 372:889-896(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.
[2]"Purification and characterization of the main allergen of Plantago lanceolata pollen, Pla l 1."
Calabozo B., Barber D., Polo F.
Clin. Exp. Allergy 31:322-330(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-18.
Tissue: Pollen.
[3]"Studies on the carbohydrate moiety of Pla l 1 allergen. Identification of a major N-glycan and significance for the immunoglobulin E-binding activity."
Calabozo B., Barber D., Polo F.
Clin. Exp. Allergy 32:1628-1634(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE OF CARBOHYDRATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ313166 mRNA. Translation: CAC41633.1.
AJ313167 mRNA. Translation: CAC41634.1.
AJ313168 mRNA. Translation: CAC41635.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome1323. Pla l 1.0101.
1324. Pla l 1.0102.
1325. Pla l 1.0103.
574. Pla l 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR006041. Pollen_Ole_e1_allergen.
[Graphical view]
PfamPF01190. Pollen_Ole_e_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLAL1_PLALA
AccessionPrimary (citable) accession number: P82242
Secondary accession number(s): Q93X26, Q949A3, Q949A4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: February 19, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries