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Protein

Kappa-hexatoxin-Hv1a

Gene
N/A
Organism
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei2Important for the neurotoxic activityBy similarity1
Sitei8Critical for the neurotoxic activityBy similarity1
Sitei9Critical for the neurotoxic activityBy similarity1
Sitei13Critical for the neurotoxic activityBy similarity1
Sitei14Critical for the neurotoxic activityBy similarity1
Sitei30Important for the neurotoxic activityBy similarity1
Sitei32Critical for the neurotoxic activityBy similarity1

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-hexatoxin-Hv1a
Short name:
Kappa-HXTX-Hv1a
Alternative name(s):
Janus-atracotoxin-Hv1a
Short name:
Janus-AcTx-Hv1a
Kappa-atracotoxin-Hv1a
Short name:
Kappa-AcTx-Hv1a
OrganismiHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Taxonomic identifieri6904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000172. kappa-hexatoxin-Hv1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449961 – 36Kappa-hexatoxin-Hv1aAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 17By similarity
Disulfide bondi10 ↔ 22By similarity
Disulfide bondi13 ↔ 14By similarity
Disulfide bondi16 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the Shiva superfamily. Kappa toxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR012499. Toxin_16.
[Graphical view]
PfamiPF07945. Toxin_16. 1 hit.
[Graphical view]
PROSITEiPS60020. J_ACTX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TICTGADRPC AACCPCCPGT SCQGPESNGV VYCRNF
Length:36
Mass (Da):3,685
Last modified:May 30, 2000 - v1
Checksum:iD1598B2560BFE997
GO

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000172. kappa-hexatoxin-Hv1a.

Family and domain databases

InterProiIPR012499. Toxin_16.
[Graphical view]
PfamiPF07945. Toxin_16. 1 hit.
[Graphical view]
PROSITEiPS60020. J_ACTX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTK1A_HADVE
AccessioniPrimary (citable) accession number: P82227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

This toxin should be named lambda-hexatoxin-Hv1a (instead of kappa), since lambda is the Greek letter attributed to calcium-activated potassium (KCa) channel impairing toxins (according to the nomenclature of King et al., 2008).Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.