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Protein

Kappa-hexatoxin-Hv1a

Gene
N/A
Organism
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2 – 21Important for the neurotoxic activityBy similarity
Sitei8 – 81Critical for the neurotoxic activityBy similarity
Sitei9 – 91Critical for the neurotoxic activityBy similarity
Sitei13 – 131Critical for the neurotoxic activityBy similarity
Sitei14 – 141Critical for the neurotoxic activityBy similarity
Sitei30 – 301Important for the neurotoxic activityBy similarity
Sitei32 – 321Critical for the neurotoxic activityBy similarity

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-hexatoxin-Hv1a
Short name:
Kappa-HXTX-Hv1a
Alternative name(s):
Janus-atracotoxin-Hv1a
Short name:
Janus-AcTx-Hv1a
Kappa-atracotoxin-Hv1a
Short name:
Kappa-AcTx-Hv1a
OrganismiHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Taxonomic identifieri6904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000172. kappa-hexatoxin-Hv1a.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Kappa-hexatoxin-Hv1aPRO_0000044996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 17By similarity
Disulfide bondi10 ↔ 22By similarity
Disulfide bondi13 ↔ 14By similarity
Disulfide bondi16 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the Shiva superfamily. Kappa toxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR012499. Toxin_16.
[Graphical view]
PfamiPF07945. Toxin_16. 1 hit.
[Graphical view]
PROSITEiPS60020. J_ACTX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TICTGADRPC AACCPCCPGT SCQGPESNGV VYCRNF
Length:36
Mass (Da):3,685
Last modified:May 30, 2000 - v1
Checksum:iD1598B2560BFE997
GO

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000172. kappa-hexatoxin-Hv1a.

Family and domain databases

InterProiIPR012499. Toxin_16.
[Graphical view]
PfamiPF07945. Toxin_16. 1 hit.
[Graphical view]
PROSITEiPS60020. J_ACTX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge."
    Wang X.-H., Connor M., Smith R., Maciejewski M.W., Howden M.E.H., Nicholson G.M., Christie M.J., King G.F.
    Nat. Struct. Biol. 7:505-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiTK1A_HADVE
AccessioniPrimary (citable) accession number: P82227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

This toxin should be named lambda-hexatoxin-Hv1a (instead of kappa), since lambda is the Greek letter attributed to calcium-activated potassium (KCa) channel impairing toxins (according to the nomenclature of King et al., 2008).Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.