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Protein

Kappa-hexatoxin-Hv1a

Gene
N/A
Organism
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type).By similarity

Caution

This toxin should be named lambda-hexatoxin-Hv1a (instead of kappa), since lambda is the Greek letter attributed to calcium-activated potassium (KCa) channel impairing toxins (according to the nomenclature of King et al., 2008).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei2Important for the neurotoxic activityBy similarity1
Sitei8Critical for the neurotoxic activityBy similarity1
Sitei9Critical for the neurotoxic activityBy similarity1
Sitei13Critical for the neurotoxic activityBy similarity1
Sitei14Critical for the neurotoxic activityBy similarity1
Sitei30Important for the neurotoxic activityBy similarity1
Sitei32Critical for the neurotoxic activityBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-hexatoxin-Hv1a
Short name:
Kappa-HXTX-Hv1a
Alternative name(s):
Janus-atracotoxin-Hv1a
Short name:
Janus-AcTx-Hv1a
Kappa-atracotoxin-Hv1a
Short name:
Kappa-AcTx-Hv1a
OrganismiHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Taxonomic identifieri6904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000172 kappa-hexatoxin-Hv1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449961 – 36Kappa-hexatoxin-Hv1aAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 17By similarity
Disulfide bondi10 ↔ 22By similarity
Disulfide bondi13 ↔ 14By similarity
Disulfide bondi16 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP82227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the neurotoxin 11 (kappa toxin) family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012499 Toxin_16
PfamiView protein in Pfam
PF07945 Toxin_16, 1 hit
PROSITEiView protein in PROSITE
PS60020 J_ACTX, 1 hit

Sequencei

Sequence statusi: Complete.

P82227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TICTGADRPC AACCPCCPGT SCQGPESNGV VYCRNF
Length:36
Mass (Da):3,685
Last modified:May 30, 2000 - v1
Checksum:iD1598B2560BFE997
GO

Similar proteinsi

Entry informationi

Entry nameiTK1A_HADVE
AccessioniPrimary (citable) accession number: P82227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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