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P82227 (TJT1A_HADVE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kappa-hexatoxin-Hv1a

Short name=Kappa-HXTX-Hv1a
Alternative name(s):
Janus-atracotoxin-Hv1a
Short name=Janus-AcTx-Hv1a
Kappa-atracotoxin-Hv1a
Short name=Kappa-AcTx-Hv1a
OrganismHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Taxonomic identifier6904 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Protein attributes

Sequence length36 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This excitatory toxin inhibits insect voltage-gated potassium channels. Ref.2

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similarities

Belongs to the janus-atracotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainKnottin
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3636Kappa-hexatoxin-Hv1a
PRO_0000044996

Sites

Site21Important for the neurotoxic activity By similarity
Site81Critical for the neurotoxic activity By similarity
Site91Critical for the neurotoxic activity By similarity
Site131Critical for the neurotoxic activity By similarity
Site141Critical for the neurotoxic activity By similarity
Site301Important for the neurotoxic activity By similarity
Site321Critical for the neurotoxic activity By similarity

Amino acid modifications

Disulfide bond3 ↔ 17 By similarity
Disulfide bond10 ↔ 22 By similarity
Disulfide bond13 ↔ 14 By similarity
Disulfide bond16 ↔ 33 By similarity

Sequences

Sequence LengthMass (Da)Tools
P82227 [UniParc].

Last modified May 30, 2000. Version 1.
Checksum: D1598B2560BFE997

FASTA363,685
        10         20         30 
TICTGADRPC AACCPCCPGT SCQGPESNGV VYCRNF 

« Hide

References

[1]"Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge."
Wang X.-H., Connor M., Smith R., Maciejewski M.W., Howden M.E.H., Nicholson G.M., Christie M.J., King G.F.
Nat. Struct. Biol. 7:505-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel."
Nicholson G.M., Little M.J., Birinyi-Strachan L.C.
Toxicon 43:587-599(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000172. kappa-hexatoxin-Hv1a.

Family and domain databases

InterProIPR012499. Toxin_16.
[Graphical view]
PfamPF07945. Toxin_16. 1 hit.
[Graphical view]
PROSITEPS60020. J_ACTX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTJT1A_HADVE
AccessionPrimary (citable) accession number: P82227
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 16, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families