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P82226

- TJT1B_HADVE

UniProt

P82226 - TJT1B_HADVE

Protein

Kappa-hexatoxin-Hv1b

Gene
N/A
Organism
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This excitatory toxin inhibits insect voltage-gated potassium channels.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei2 – 21Important for the neurotoxic activityBy similarity
    Sitei8 – 81Critical for the neurotoxic activityBy similarity
    Sitei9 – 91Critical for the neurotoxic activityBy similarity
    Sitei13 – 131Critical for the neurotoxic activityBy similarity
    Sitei14 – 141Critical for the neurotoxic activityBy similarity
    Sitei30 – 301Important for the neurotoxic activityBy similarity
    Sitei32 – 321Critical for the neurotoxic activityBy similarity

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kappa-hexatoxin-Hv1b
    Short name:
    Kappa-HXTX-Hv1b
    Alternative name(s):
    Janus-atracotoxin-Hv1b
    Short name:
    Janus-AcTx-Hv1b
    Kappa-atracotoxin-Hv1b
    Short name:
    Kappa-AcTx-Hv1b
    OrganismiHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
    Taxonomic identifieri6904 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

    Organism-specific databases

    ArachnoServeriAS000173. kappa-hexatoxin-Hv1b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3636Kappa-hexatoxin-Hv1bPRO_0000044997Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 17By similarity
    Disulfide bondi10 ↔ 22By similarity
    Disulfide bondi13 ↔ 14By similarity
    Disulfide bondi16 ↔ 33By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP82226.
    SMRiP82226. Positions 1-36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

    Sequence similaritiesi

    Belongs to the janus-atracotoxin family.Curated

    Keywords - Domaini

    Knottin

    Family and domain databases

    InterProiIPR012499. Toxin_16.
    [Graphical view]
    PfamiPF07945. Toxin_16. 1 hit.
    [Graphical view]
    PROSITEiPS60020. J_ACTX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82226-1 [UniParc]FASTAAdd to Basket

    « Hide

    TICTGADRPC AACCPCCPGT SCQGPEPNGV SYCRND                  36
    Length:36
    Mass (Da):3,651
    Last modified:May 30, 2000 - v1
    Checksum:iD23A442560B89997
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P82226.
    SMRi P82226. Positions 1-36.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ArachnoServeri AS000173. kappa-hexatoxin-Hv1b.

    Family and domain databases

    InterProi IPR012499. Toxin_16.
    [Graphical view ]
    Pfami PF07945. Toxin_16. 1 hit.
    [Graphical view ]
    PROSITEi PS60020. J_ACTX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge."
      Wang X.-H., Connor M., Smith R., Maciejewski M.W., Howden M.E.H., Nicholson G.M., Christie M.J., King G.F.
      Nat. Struct. Biol. 7:505-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.
    2. "Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel."
      Nicholson G.M., Little M.J., Birinyi-Strachan L.C.
      Toxicon 43:587-599(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTJT1B_HADVE
    AccessioniPrimary (citable) accession number: P82226
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3