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P82226

- TJT1B_HADVE

UniProt

P82226 - TJT1B_HADVE

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Protein

Kappa-hexatoxin-Hv1b

Gene
N/A
Organism
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This excitatory toxin inhibits insect voltage-gated potassium channels.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2 – 21Important for the neurotoxic activity By similarity
Sitei8 – 81Critical for the neurotoxic activity By similarity
Sitei9 – 91Critical for the neurotoxic activity By similarity
Sitei13 – 131Critical for the neurotoxic activity By similarity
Sitei14 – 141Critical for the neurotoxic activity By similarity
Sitei30 – 301Important for the neurotoxic activity By similarity
Sitei32 – 321Critical for the neurotoxic activity By similarity

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-hexatoxin-Hv1b
Short name:
Kappa-HXTX-Hv1b
Alternative name(s):
Janus-atracotoxin-Hv1b
Short name:
Janus-AcTx-Hv1b
Kappa-atracotoxin-Hv1b
Short name:
Kappa-AcTx-Hv1b
OrganismiHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Taxonomic identifieri6904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000173. kappa-hexatoxin-Hv1b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Kappa-hexatoxin-Hv1bPRO_0000044997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 17 By similarity
Disulfide bondi10 ↔ 22 By similarity
Disulfide bondi13 ↔ 14 By similarity
Disulfide bondi16 ↔ 33 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP82226.
SMRiP82226. Positions 1-36.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similaritiesi

Belongs to the janus-atracotoxin family.

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR012499. Toxin_16.
[Graphical view]
PfamiPF07945. Toxin_16. 1 hit.
[Graphical view]
PROSITEiPS60020. J_ACTX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82226-1 [UniParc]FASTAAdd to Basket

« Hide

TICTGADRPC AACCPCCPGT SCQGPEPNGV SYCRND                  36
Length:36
Mass (Da):3,651
Last modified:May 30, 2000 - v1
Checksum:iD23A442560B89997
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P82226.
SMRi P82226. Positions 1-36.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000173. kappa-hexatoxin-Hv1b.

Family and domain databases

InterProi IPR012499. Toxin_16.
[Graphical view ]
Pfami PF07945. Toxin_16. 1 hit.
[Graphical view ]
PROSITEi PS60020. J_ACTX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge."
    Wang X.-H., Connor M., Smith R., Maciejewski M.W., Howden M.E.H., Nicholson G.M., Christie M.J., King G.F.
    Nat. Struct. Biol. 7:505-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.
  2. "Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel."
    Nicholson G.M., Little M.J., Birinyi-Strachan L.C.
    Toxicon 43:587-599(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTJT1B_HADVE
AccessioniPrimary (citable) accession number: P82226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 16, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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