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P82198

- BGH3_MOUSE

UniProt

P82198 - BGH3_MOUSE

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Protein

Transforming growth factor-beta-induced protein ig-h3

Gene

Tgfbi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation (By similarity).By similarity

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. cell adhesion Source: MGI
  3. chondrocyte differentiation Source: Ensembl
  4. extracellular matrix organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor-beta-induced protein ig-h3
Short name:
Beta ig-h3
Gene namesi
Name:Tgfbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:99959. Tgfbi.

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity
Note: May be associated both with microfibrils and with the cell surface.By similarity

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. proteinaceous extracellular matrix Source: MGI
  5. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 683660Transforming growth factor-beta-induced protein ig-h3PRO_0000041980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 85PROSITE-ProRule annotation
Disulfide bondi65 ↔ 74PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
Modified residuei108 – 10814-carboxyglutamateSequence Analysis
Modified residuei126 – 12614-carboxyglutamateSequence Analysis
Modified residuei131 – 13114-carboxyglutamateSequence Analysis
Modified residuei133 – 13314-carboxyglutamateSequence Analysis
Modified residuei146 – 14614-carboxyglutamateSequence Analysis
Modified residuei154 – 15414-carboxyglutamateSequence Analysis
Modified residuei166 – 16614-carboxyglutamateSequence Analysis
Modified residuei184 – 18414-carboxyglutamateSequence Analysis
Modified residuei248 – 24814-carboxyglutamateSequence Analysis
Modified residuei250 – 25014-carboxyglutamateSequence Analysis
Modified residuei254 – 25414-carboxyglutamateSequence Analysis
Modified residuei270 – 27014-carboxyglutamateSequence Analysis
Modified residuei283 – 28314-carboxyglutamateSequence Analysis
Modified residuei286 – 28614-carboxyglutamateSequence Analysis
Modified residuei291 – 29114-carboxyglutamateSequence Analysis
Modified residuei301 – 30114-carboxyglutamateSequence Analysis
Modified residuei319 – 31914-carboxyglutamateSequence Analysis
Modified residuei328 – 32814-carboxyglutamateSequence Analysis
Modified residuei336 – 33614-carboxyglutamateSequence Analysis
Modified residuei529 – 52914-carboxyglutamateSequence Analysis
Modified residuei534 – 53414-carboxyglutamateSequence Analysis
Modified residuei545 – 54514-carboxyglutamateSequence Analysis
Modified residuei554 – 55414-carboxyglutamateSequence Analysis
Modified residuei564 – 56414-carboxyglutamateSequence Analysis
Modified residuei576 – 57614-carboxyglutamateSequence Analysis
Modified residuei598 – 59814-carboxyglutamateSequence Analysis
Modified residuei611 – 61114-carboxyglutamateSequence Analysis
Modified residuei615 – 61514-carboxyglutamateSequence Analysis

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

MaxQBiP82198.
PaxDbiP82198.
PRIDEiP82198.

PTM databases

PhosphoSiteiP82198.

Expressioni

Inductioni

By TGF-beta.

Gene expression databases

BgeeiP82198.
CleanExiMM_TGFBI.
ExpressionAtlasiP82198. baseline and differential.
GenevestigatoriP82198.

Interactioni

Protein-protein interaction databases

IntActiP82198. 1 interaction.
MINTiMINT-4106293.

Structurei

3D structure databases

ProteinModelPortaliP82198.
SMRiP82198. Positions 125-236, 252-373, 502-634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 9955EMIPROSITE-ProRule annotationAdd
BLAST
Domaini103 – 236134FAS1 1PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 371132FAS1 2PROSITE-ProRule annotationAdd
BLAST
Domaini375 – 498124FAS1 3PROSITE-ProRule annotationAdd
BLAST
Domaini502 – 632131FAS1 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi642 – 6443Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 1 EMI domain.PROSITE-ProRule annotation
Contains 4 FAS1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2335.
GeneTreeiENSGT00530000063860.
HOGENOMiHOG000220865.
HOVERGENiHBG000715.
InParanoidiP82198.
OMAiQFTLLAP.
OrthoDBiEOG7N8ZV1.
PhylomeDBiP82198.
TreeFamiTF316269.

Family and domain databases

Gene3Di2.30.180.10. 4 hits.
InterProiIPR011489. EMI_domain.
IPR000782. FAS1_domain.
IPR016666. TGFb-ind_bIGH3/osteoblast_fac2.
[Graphical view]
PfamiPF02469. Fasciclin. 4 hits.
[Graphical view]
PIRSFiPIRSF016553. BIGH3_OSF2. 1 hit.
SMARTiSM00554. FAS1. 4 hits.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 4 hits.
PROSITEiPS51041. EMI. 1 hit.
PS50213. FAS1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82198-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLMRLLTL ALALSVGPAG TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA
60 70 80 90 100
VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA
110 120 130 140 150
LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS
160 170 180 190 200
LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI
210 220 230 240 250
QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE
260 270 280 290 300
DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP
310 320 330 340 350
EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA
360 370 380 390 400
VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL
410 420 430 440 450
DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY
460 470 480 490 500
SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP
510 520 530 540 550
PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM
560 570 580 590 600
PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS
610 620 630 640 650
SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA
660 670 680
LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH
Length:683
Mass (Da):74,597
Last modified:May 1, 2000 - v1
Checksum:i2B6E9DBB9C50F52B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19932 mRNA. Translation: AAC37658.1.
AK084431 mRNA. Translation: BAC39181.1.
AK142323 mRNA. Translation: BAE25032.1.
AK151680 mRNA. Translation: BAE30605.1.
AK152365 mRNA. Translation: BAE31155.1.
AK155572 mRNA. Translation: BAE33330.1.
AK155828 mRNA. Translation: BAE33452.1.
AK170495 mRNA. Translation: BAE41834.1.
CCDSiCCDS36680.1.
RefSeqiNP_033395.1. NM_009369.4.
UniGeneiMm.14455.

Genome annotation databases

EnsembliENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493.
GeneIDi21810.
KEGGimmu:21810.
UCSCiuc011zae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19932 mRNA. Translation: AAC37658.1 .
AK084431 mRNA. Translation: BAC39181.1 .
AK142323 mRNA. Translation: BAE25032.1 .
AK151680 mRNA. Translation: BAE30605.1 .
AK152365 mRNA. Translation: BAE31155.1 .
AK155572 mRNA. Translation: BAE33330.1 .
AK155828 mRNA. Translation: BAE33452.1 .
AK170495 mRNA. Translation: BAE41834.1 .
CCDSi CCDS36680.1.
RefSeqi NP_033395.1. NM_009369.4.
UniGenei Mm.14455.

3D structure databases

ProteinModelPortali P82198.
SMRi P82198. Positions 125-236, 252-373, 502-634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P82198. 1 interaction.
MINTi MINT-4106293.

PTM databases

PhosphoSitei P82198.

Proteomic databases

MaxQBi P82198.
PaxDbi P82198.
PRIDEi P82198.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045173 ; ENSMUSP00000037719 ; ENSMUSG00000035493 .
GeneIDi 21810.
KEGGi mmu:21810.
UCSCi uc011zae.1. mouse.

Organism-specific databases

CTDi 7045.
MGIi MGI:99959. Tgfbi.

Phylogenomic databases

eggNOGi COG2335.
GeneTreei ENSGT00530000063860.
HOGENOMi HOG000220865.
HOVERGENi HBG000715.
InParanoidi P82198.
OMAi QFTLLAP.
OrthoDBi EOG7N8ZV1.
PhylomeDBi P82198.
TreeFami TF316269.

Enzyme and pathway databases

Reactomei REACT_198563. Amyloids.

Miscellaneous databases

NextBioi 301198.
PROi P82198.
SOURCEi Search...

Gene expression databases

Bgeei P82198.
CleanExi MM_TGFBI.
ExpressionAtlasi P82198. baseline and differential.
Genevestigatori P82198.

Family and domain databases

Gene3Di 2.30.180.10. 4 hits.
InterProi IPR011489. EMI_domain.
IPR000782. FAS1_domain.
IPR016666. TGFb-ind_bIGH3/osteoblast_fac2.
[Graphical view ]
Pfami PF02469. Fasciclin. 4 hits.
[Graphical view ]
PIRSFi PIRSF016553. BIGH3_OSF2. 1 hit.
SMARTi SM00554. FAS1. 4 hits.
[Graphical view ]
SUPFAMi SSF82153. SSF82153. 4 hits.
PROSITEi PS51041. EMI. 1 hit.
PS50213. FAS1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice."
    Skonier J., Bennett K., Rothwell V., Kosowski S., Plowman G., Wallace P., Edelhoff S., Disteche C.M., Neubauer M., Marquardt H., Rodgers J., Purchio A.F.
    DNA Cell Biol. 13:571-584(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: G8.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Eye and Heart.

Entry informationi

Entry nameiBGH3_MOUSE
AccessioniPrimary (citable) accession number: P82198
Secondary accession number(s): Q3U9R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3