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P82198

- BGH3_MOUSE

UniProt

P82198 - BGH3_MOUSE

Protein

Transforming growth factor-beta-induced protein ig-h3

Gene

Tgfbi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation By similarity.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cell adhesion Source: MGI
    3. chondrocyte differentiation Source: Ensembl
    4. extracellular matrix organization Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming growth factor-beta-induced protein ig-h3
    Short name:
    Beta ig-h3
    Gene namesi
    Name:Tgfbi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:99959. Tgfbi.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix By similarity
    Note: May be associated both with microfibrils and with the cell surface.By similarity

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. extracellular space Source: MGI
    3. extracellular vesicular exosome Source: Ensembl
    4. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 683660Transforming growth factor-beta-induced protein ig-h3PRO_0000041980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 85PROSITE-ProRule annotation
    Disulfide bondi65 ↔ 74PROSITE-ProRule annotation
    Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
    Modified residuei108 – 10814-carboxyglutamateSequence Analysis
    Modified residuei126 – 12614-carboxyglutamateSequence Analysis
    Modified residuei131 – 13114-carboxyglutamateSequence Analysis
    Modified residuei133 – 13314-carboxyglutamateSequence Analysis
    Modified residuei146 – 14614-carboxyglutamateSequence Analysis
    Modified residuei154 – 15414-carboxyglutamateSequence Analysis
    Modified residuei166 – 16614-carboxyglutamateSequence Analysis
    Modified residuei184 – 18414-carboxyglutamateSequence Analysis
    Modified residuei248 – 24814-carboxyglutamateSequence Analysis
    Modified residuei250 – 25014-carboxyglutamateSequence Analysis
    Modified residuei254 – 25414-carboxyglutamateSequence Analysis
    Modified residuei270 – 27014-carboxyglutamateSequence Analysis
    Modified residuei283 – 28314-carboxyglutamateSequence Analysis
    Modified residuei286 – 28614-carboxyglutamateSequence Analysis
    Modified residuei291 – 29114-carboxyglutamateSequence Analysis
    Modified residuei301 – 30114-carboxyglutamateSequence Analysis
    Modified residuei319 – 31914-carboxyglutamateSequence Analysis
    Modified residuei328 – 32814-carboxyglutamateSequence Analysis
    Modified residuei336 – 33614-carboxyglutamateSequence Analysis
    Modified residuei529 – 52914-carboxyglutamateSequence Analysis
    Modified residuei534 – 53414-carboxyglutamateSequence Analysis
    Modified residuei545 – 54514-carboxyglutamateSequence Analysis
    Modified residuei554 – 55414-carboxyglutamateSequence Analysis
    Modified residuei564 – 56414-carboxyglutamateSequence Analysis
    Modified residuei576 – 57614-carboxyglutamateSequence Analysis
    Modified residuei598 – 59814-carboxyglutamateSequence Analysis
    Modified residuei611 – 61114-carboxyglutamateSequence Analysis
    Modified residuei615 – 61514-carboxyglutamateSequence Analysis

    Post-translational modificationi

    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Gamma-carboxyglutamic acid

    Proteomic databases

    MaxQBiP82198.
    PaxDbiP82198.
    PRIDEiP82198.

    PTM databases

    PhosphoSiteiP82198.

    Expressioni

    Inductioni

    By TGF-beta.

    Gene expression databases

    ArrayExpressiP82198.
    BgeeiP82198.
    CleanExiMM_TGFBI.
    GenevestigatoriP82198.

    Interactioni

    Protein-protein interaction databases

    IntActiP82198. 1 interaction.
    MINTiMINT-4106293.

    Structurei

    3D structure databases

    ProteinModelPortaliP82198.
    SMRiP82198. Positions 125-236, 252-373, 502-634.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 9955EMIPROSITE-ProRule annotationAdd
    BLAST
    Domaini103 – 236134FAS1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 371132FAS1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini375 – 498124FAS1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini502 – 632131FAS1 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi642 – 6443Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 1 EMI domain.PROSITE-ProRule annotation
    Contains 4 FAS1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2335.
    GeneTreeiENSGT00530000063860.
    HOGENOMiHOG000220865.
    HOVERGENiHBG000715.
    InParanoidiP82198.
    OMAiQFTLLAP.
    OrthoDBiEOG7N8ZV1.
    PhylomeDBiP82198.
    TreeFamiTF316269.

    Family and domain databases

    Gene3Di2.30.180.10. 4 hits.
    InterProiIPR011489. EMI_domain.
    IPR000782. FAS1_domain.
    IPR016666. TGFb-ind_bIGH3/osteoblast_fac2.
    [Graphical view]
    PfamiPF02469. Fasciclin. 4 hits.
    [Graphical view]
    PIRSFiPIRSF016553. BIGH3_OSF2. 1 hit.
    SMARTiSM00554. FAS1. 4 hits.
    [Graphical view]
    SUPFAMiSSF82153. SSF82153. 4 hits.
    PROSITEiPS51041. EMI. 1 hit.
    PS50213. FAS1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P82198-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLMRLLTL ALALSVGPAG TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA    50
    VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA 100
    LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS 150
    LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI 200
    QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE 250
    DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP 300
    EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA 350
    VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL 400
    DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY 450
    SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP 500
    PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM 550
    PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS 600
    SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA 650
    LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH 683
    Length:683
    Mass (Da):74,597
    Last modified:May 1, 2000 - v1
    Checksum:i2B6E9DBB9C50F52B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19932 mRNA. Translation: AAC37658.1.
    AK084431 mRNA. Translation: BAC39181.1.
    AK142323 mRNA. Translation: BAE25032.1.
    AK151680 mRNA. Translation: BAE30605.1.
    AK152365 mRNA. Translation: BAE31155.1.
    AK155572 mRNA. Translation: BAE33330.1.
    AK155828 mRNA. Translation: BAE33452.1.
    AK170495 mRNA. Translation: BAE41834.1.
    CCDSiCCDS36680.1.
    RefSeqiNP_033395.1. NM_009369.4.
    UniGeneiMm.14455.

    Genome annotation databases

    EnsembliENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493.
    GeneIDi21810.
    KEGGimmu:21810.
    UCSCiuc011zae.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19932 mRNA. Translation: AAC37658.1 .
    AK084431 mRNA. Translation: BAC39181.1 .
    AK142323 mRNA. Translation: BAE25032.1 .
    AK151680 mRNA. Translation: BAE30605.1 .
    AK152365 mRNA. Translation: BAE31155.1 .
    AK155572 mRNA. Translation: BAE33330.1 .
    AK155828 mRNA. Translation: BAE33452.1 .
    AK170495 mRNA. Translation: BAE41834.1 .
    CCDSi CCDS36680.1.
    RefSeqi NP_033395.1. NM_009369.4.
    UniGenei Mm.14455.

    3D structure databases

    ProteinModelPortali P82198.
    SMRi P82198. Positions 125-236, 252-373, 502-634.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P82198. 1 interaction.
    MINTi MINT-4106293.

    PTM databases

    PhosphoSitei P82198.

    Proteomic databases

    MaxQBi P82198.
    PaxDbi P82198.
    PRIDEi P82198.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045173 ; ENSMUSP00000037719 ; ENSMUSG00000035493 .
    GeneIDi 21810.
    KEGGi mmu:21810.
    UCSCi uc011zae.1. mouse.

    Organism-specific databases

    CTDi 7045.
    MGIi MGI:99959. Tgfbi.

    Phylogenomic databases

    eggNOGi COG2335.
    GeneTreei ENSGT00530000063860.
    HOGENOMi HOG000220865.
    HOVERGENi HBG000715.
    InParanoidi P82198.
    OMAi QFTLLAP.
    OrthoDBi EOG7N8ZV1.
    PhylomeDBi P82198.
    TreeFami TF316269.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    NextBioi 301198.
    PROi P82198.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P82198.
    Bgeei P82198.
    CleanExi MM_TGFBI.
    Genevestigatori P82198.

    Family and domain databases

    Gene3Di 2.30.180.10. 4 hits.
    InterProi IPR011489. EMI_domain.
    IPR000782. FAS1_domain.
    IPR016666. TGFb-ind_bIGH3/osteoblast_fac2.
    [Graphical view ]
    Pfami PF02469. Fasciclin. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF016553. BIGH3_OSF2. 1 hit.
    SMARTi SM00554. FAS1. 4 hits.
    [Graphical view ]
    SUPFAMi SSF82153. SSF82153. 4 hits.
    PROSITEi PS51041. EMI. 1 hit.
    PS50213. FAS1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice."
      Skonier J., Bennett K., Rothwell V., Kosowski S., Plowman G., Wallace P., Edelhoff S., Disteche C.M., Neubauer M., Marquardt H., Rodgers J., Purchio A.F.
      DNA Cell Biol. 13:571-584(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: G8.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Eye and Heart.

    Entry informationi

    Entry nameiBGH3_MOUSE
    AccessioniPrimary (citable) accession number: P82198
    Secondary accession number(s): Q3U9R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3