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Protein

Transforming growth factor-beta-induced protein ig-h3

Gene

Tgfbi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cell adhesion molecule binding Source: GO_Central
  • collagen binding Source: MGI
  • extracellular matrix binding Source: MGI

GO - Biological processi

  • angiogenesis Source: Ensembl
  • cell adhesion Source: MGI
  • cell proliferation Source: InterPro
  • chondrocyte differentiation Source: Ensembl
  • extracellular matrix organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor-beta-induced protein ig-h3
Short name:
Beta ig-h3
Gene namesi
Name:Tgfbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99959. Tgfbi.

Subcellular locationi

  • Secreted By similarity
  • Secretedextracellular spaceextracellular matrix By similarity

  • Note: May be associated both with microfibrils and with the cell surface.By similarity

GO - Cellular componenti

  • basement membrane Source: Ensembl
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • extracellular space Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000004198024 – 683Transforming growth factor-beta-induced protein ig-h3Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Disulfide bondi49 ↔ 85PROSITE-ProRule annotation
Disulfide bondi65 ↔ 74PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.By similarity

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQBiP82198.
PaxDbiP82198.
PRIDEiP82198.

PTM databases

PhosphoSitePlusiP82198.

Expressioni

Tissue specificityi

Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701).1 Publication

Developmental stagei

Expressed in the embryo at 12 dpc (PubMed:8024701).1 Publication

Gene expression databases

BgeeiENSMUSG00000035493.
CleanExiMM_TGFBI.
ExpressionAtlasiP82198. baseline and differential.
GenevisibleiP82198. MM.

Interactioni

Subunit structurei

Binds to type I, II, and IV collagens.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP82198. 1 interactor.
MINTiMINT-4106293.
STRINGi10090.ENSMUSP00000037719.

Structurei

3D structure databases

ProteinModelPortaliP82198.
SMRiP82198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 99EMIPROSITE-ProRule annotationAdd BLAST55
Domaini103 – 236FAS1 1PROSITE-ProRule annotationAdd BLAST134
Domaini240 – 371FAS1 2PROSITE-ProRule annotationAdd BLAST132
Domaini375 – 498FAS1 3PROSITE-ProRule annotationAdd BLAST124
Domaini502 – 632FAS1 4PROSITE-ProRule annotationAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi642 – 644Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 1 EMI domain.PROSITE-ProRule annotation
Contains 4 FAS1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1437. Eukaryota.
COG2335. LUCA.
GeneTreeiENSGT00530000063860.
HOGENOMiHOG000220865.
HOVERGENiHBG000715.
InParanoidiP82198.
KOiK19519.
OMAiVITYECC.
OrthoDBiEOG091G020T.
PhylomeDBiP82198.
TreeFamiTF316269.

Family and domain databases

Gene3Di2.30.180.10. 4 hits.
InterProiIPR011489. EMI_domain.
IPR000782. FAS1_domain.
IPR032954. TGFBI.
IPR016666. TGFBI/POSTN.
[Graphical view]
PANTHERiPTHR10900:SF82. PTHR10900:SF82. 2 hits.
PfamiPF02469. Fasciclin. 4 hits.
[Graphical view]
PIRSFiPIRSF016553. BIGH3_OSF2. 1 hit.
SMARTiSM00554. FAS1. 4 hits.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 4 hits.
PROSITEiPS51041. EMI. 1 hit.
PS50213. FAS1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLMRLLTL ALALSVGPAG TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA
60 70 80 90 100
VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA
110 120 130 140 150
LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS
160 170 180 190 200
LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI
210 220 230 240 250
QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE
260 270 280 290 300
DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP
310 320 330 340 350
EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA
360 370 380 390 400
VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL
410 420 430 440 450
DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY
460 470 480 490 500
SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP
510 520 530 540 550
PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM
560 570 580 590 600
PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS
610 620 630 640 650
SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA
660 670 680
LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH
Length:683
Mass (Da):74,597
Last modified:May 1, 2000 - v1
Checksum:i2B6E9DBB9C50F52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19932 mRNA. Translation: AAC37658.1.
AK084431 mRNA. Translation: BAC39181.1.
AK142323 mRNA. Translation: BAE25032.1.
AK151680 mRNA. Translation: BAE30605.1.
AK152365 mRNA. Translation: BAE31155.1.
AK155572 mRNA. Translation: BAE33330.1.
AK155828 mRNA. Translation: BAE33452.1.
AK170495 mRNA. Translation: BAE41834.1.
CCDSiCCDS36680.1.
RefSeqiNP_033395.1. NM_009369.4.
UniGeneiMm.14455.

Genome annotation databases

EnsembliENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493.
GeneIDi21810.
KEGGimmu:21810.
UCSCiuc011zae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19932 mRNA. Translation: AAC37658.1.
AK084431 mRNA. Translation: BAC39181.1.
AK142323 mRNA. Translation: BAE25032.1.
AK151680 mRNA. Translation: BAE30605.1.
AK152365 mRNA. Translation: BAE31155.1.
AK155572 mRNA. Translation: BAE33330.1.
AK155828 mRNA. Translation: BAE33452.1.
AK170495 mRNA. Translation: BAE41834.1.
CCDSiCCDS36680.1.
RefSeqiNP_033395.1. NM_009369.4.
UniGeneiMm.14455.

3D structure databases

ProteinModelPortaliP82198.
SMRiP82198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP82198. 1 interactor.
MINTiMINT-4106293.
STRINGi10090.ENSMUSP00000037719.

PTM databases

PhosphoSitePlusiP82198.

Proteomic databases

MaxQBiP82198.
PaxDbiP82198.
PRIDEiP82198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493.
GeneIDi21810.
KEGGimmu:21810.
UCSCiuc011zae.1. mouse.

Organism-specific databases

CTDi7045.
MGIiMGI:99959. Tgfbi.

Phylogenomic databases

eggNOGiKOG1437. Eukaryota.
COG2335. LUCA.
GeneTreeiENSGT00530000063860.
HOGENOMiHOG000220865.
HOVERGENiHBG000715.
InParanoidiP82198.
KOiK19519.
OMAiVITYECC.
OrthoDBiEOG091G020T.
PhylomeDBiP82198.
TreeFamiTF316269.

Miscellaneous databases

PROiP82198.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035493.
CleanExiMM_TGFBI.
ExpressionAtlasiP82198. baseline and differential.
GenevisibleiP82198. MM.

Family and domain databases

Gene3Di2.30.180.10. 4 hits.
InterProiIPR011489. EMI_domain.
IPR000782. FAS1_domain.
IPR032954. TGFBI.
IPR016666. TGFBI/POSTN.
[Graphical view]
PANTHERiPTHR10900:SF82. PTHR10900:SF82. 2 hits.
PfamiPF02469. Fasciclin. 4 hits.
[Graphical view]
PIRSFiPIRSF016553. BIGH3_OSF2. 1 hit.
SMARTiSM00554. FAS1. 4 hits.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 4 hits.
PROSITEiPS51041. EMI. 1 hit.
PS50213. FAS1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGH3_MOUSE
AccessioniPrimary (citable) accession number: P82198
Secondary accession number(s): Q3U9R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.