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P82172 (DLP1_ORNAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Defensin-like peptide 1

Short name=DLP-1
Alternative name(s):
Ornithorhynchus venom defensin-like peptide C
Short name=OvDLP-C
OrganismOrnithorhynchus anatinus (Duckbill platypus) [Reference proteome]
Taxonomic identifier9258 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus

Protein attributes

Sequence length66 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities. Ref.2

Subcellular location

Secreted Ref.2.

Tissue specificity

Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including intestine, kidney, spleen and testis. Ref.1 Ref.2

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionToxin
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from expression pattern Ref.2. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 6642Defensin-like peptide 1
PRO_0000079932

Amino acid modifications

Disulfide bond33 ↔ 63
Disulfide bond40 ↔ 56
Disulfide bond48 ↔ 64

Experimental info

Sequence conflict601E → G AA sequence Ref.2

Secondary structure

......... 66
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P82172 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: C338407A4788CB68

FASTA667,518
        10         20         30         40         50         60 
MRLAYLLLLL VAVLFQAGGG SVEAFVQHRP RDCESINGVC RHKDTVNCRE IFLADCYNDE 


QKCCRK 

« Hide

References

[1]"Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected."
Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.
Toxicon 52:559-565(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Solution structure of a defensin-like peptide from platypus venom."
Torres A.M., Wang X., Fletcher J.I., Alewood D., Alewood P.F., Smith R., Simpson R.J., Nicholson G.M., Sutherland S.K., Gallagher C.H., King G.F., Kuchel P.W.
Biochem. J. 341:785-794(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-66, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SYNTHESIS, STRUCTURE BY NMR OF 25-66.
Tissue: Venom and Venom gland.

Web resources

Platypus resources
Protein Spotlight

Platypus poison - Issue 29 of December 2002

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8WNMR-A25-66[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOANT00000002833; ENSOANP00000002832; ENSOANG00000001780.

Phylogenomic databases

GeneTreeENSGT00420000030416.
HOVERGENHBG107815.

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamPF08131. Defensin_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP82172.

Entry information

Entry nameDLP1_ORNAN
AccessionPrimary (citable) accession number: P82172
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: February 19, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references