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Protein

Defensin-like peptide 1

Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.1 Publication

GO - Biological processi

  • pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like peptide 1
Short name:
DLP-1
Alternative name(s):
Ornithorhynchus venom defensin-like peptide C
Short name:
OvDLP-C
OrganismiOrnithorhynchus anatinus (Duckbill platypus)
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000007993225 – 66Defensin-like peptide 1Add BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 63
Disulfide bondi40 ↔ 56
Disulfide bondi48 ↔ 64

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including intestine, kidney, spleen and testis.2 Publications

Gene expression databases

BgeeiENSOANG00000001780.

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 36Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi46 – 48Combined sources3
Beta strandi57 – 64Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8WNMR-A25-66[»]
SMRiP82172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82172.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00420000030416.
HOVERGENiHBG107815.
OrthoDBiEOG091G1945.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF08131. Defensin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAYLLLLL VAVLFQAGGG SVEAFVQHRP RDCESINGVC RHKDTVNCRE
60
IFLADCYNDE QKCCRK
Length:66
Mass (Da):7,518
Last modified:October 14, 2008 - v2
Checksum:iC338407A4788CB68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60E → G AA sequence (PubMed:10417345).Curated1

Genome annotation databases

EnsembliENSOANT00000002833; ENSOANP00000002832; ENSOANG00000001780.

Cross-referencesi

Web resourcesi

Platypus resources
Protein Spotlight

Platypus poison - Issue 29 of December 2002

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8WNMR-A25-66[»]
SMRiP82172.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOANT00000002833; ENSOANP00000002832; ENSOANG00000001780.

Phylogenomic databases

GeneTreeiENSGT00420000030416.
HOVERGENiHBG107815.
OrthoDBiEOG091G1945.

Miscellaneous databases

EvolutionaryTraceiP82172.

Gene expression databases

BgeeiENSOANG00000001780.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF08131. Defensin_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLP1_ORNAN
AccessioniPrimary (citable) accession number: P82172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.