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P82172

- DLP1_ORNAN

UniProt

P82172 - DLP1_ORNAN

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Protein

Defensin-like peptide 1

Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.1 Publication

GO - Biological processi

  1. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like peptide 1
Short name:
DLP-1
Alternative name(s):
Ornithorhynchus venom defensin-like peptide C
Short name:
OvDLP-C
OrganismiOrnithorhynchus anatinus (Duckbill platypus)
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
ProteomesiUP000002279: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 6642Defensin-like peptide 1PRO_0000079932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 63
Disulfide bondi40 ↔ 56
Disulfide bondi48 ↔ 64

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including intestine, kidney, spleen and testis.2 Publications

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 363Combined sources
Beta strandi39 – 424Combined sources
Beta strandi46 – 483Combined sources
Beta strandi57 – 648Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8WNMR-A25-66[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82172.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00420000030416.
HOVERGENiHBG107815.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF08131. Defensin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82172-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLAYLLLLL VAVLFQAGGG SVEAFVQHRP RDCESINGVC RHKDTVNCRE
60
IFLADCYNDE QKCCRK
Length:66
Mass (Da):7,518
Last modified:October 14, 2008 - v2
Checksum:iC338407A4788CB68
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601E → G AA sequence (PubMed:10417345)Curated

Genome annotation databases

EnsembliENSOANT00000002833; ENSOANP00000002832; ENSOANG00000001780.

Cross-referencesi

Web resourcesi

Platypus resources
Protein Spotlight

Platypus poison - Issue 29 of December 2002

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B8W NMR - A 25-66 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOANT00000002833 ; ENSOANP00000002832 ; ENSOANG00000001780 .

Phylogenomic databases

GeneTreei ENSGT00420000030416.
HOVERGENi HBG107815.

Miscellaneous databases

EvolutionaryTracei P82172.

Family and domain databases

Gene3Di 2.20.20.10. 1 hit.
InterProi IPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view ]
Pfami PF08131. Defensin_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected."
    Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.
    Toxicon 52:559-565(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: PROTEIN SEQUENCE OF 25-66, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SYNTHESIS, STRUCTURE BY NMR OF 25-66.
    Tissue: Venom and Venom gland.

Entry informationi

Entry nameiDLP1_ORNAN
AccessioniPrimary (citable) accession number: P82172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3