Reviewed, UniProtKB/Swiss-Prot P82141 (DLP3_ORNAN)

Names and origin

Protein names	Recommended name:     Defensin-like peptide 3       Short name=DLP-3
Organism	Ornithorhynchus anatinus (Duckbill platypus)
Taxonomic identifier	9258 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Monotremata › Ornithorhynchidae › Ornithorhynchus

Protein attributes

Sequence length	38 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities. Ref.1
Subcellular location	Secreted Ref.1.
Tissue specificity	Produced by the crural gland and detected in venom from the spur located on each male hind leg. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Ref.1 Inferred from expression pattern. Source: UniProtKB
Cellular component	extracellular region Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 38	38	Defensin-like peptide 3		PRO_0000044773
Amino acid modifications
	Disulfide bond	13 ↔ 29		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P82141-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4B2D1C6BB407F3DF	FASTA	38	4,721
	10 20 30 FEMQYCWSHS GVCRDKSERN NKPMAWTYCE NRQKKCEF

References

[1]

"Solution structure of a defensin-like peptide from platypus venom." Torres A.M., Wang X., Fletcher J.I., Alewood D., Alewood P.F., Smith R., Simpson R.J., Nicholson G.M., Sutherland S.K., Gallagher C.H., King G.F., Kuchel P.W. Biochem. J. 341:785-794(1999) [PubMed: 10417345] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Venom and Venom gland.

Web resources

Protein Spotlight

Platypus poison - Issue 29 of December 2002

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P82141.
Family and domain databases
InterPro	IPR012553. Defensin_3. [Graphical view]
Pfam	PF08131. Defensin_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLP3_ORNAN

Accession

Primary (citable) accession number: P82141

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)