P82141 (DLP3_ORNAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Defensin-like peptide 3 Short name=DLP-3
Organism	Ornithorhynchus anatinus (Duckbill platypus) [Reference proteome]
Taxonomic identifier	9258 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Prototheria › Monotremata › Ornithorhynchidae › Ornithorhynchus

Protein attributes

Sequence length	38 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities. Ref.1
Subcellular location	Secreted Ref.1.
Tissue specificity	Produced by the crural gland and detected in venom from the spur located on each male hind leg. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Toxin
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from expression pattern Ref.1. Source: UniProtKB
Cellular_component	extracellular region Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 38	38	Defensin-like peptide 3		PRO_0000044773
Amino acid modifications
	Disulfide bond	13 ↔ 29		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P82141 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 4B2D1C6BB407F3DF	FASTA	38	4,721
	10 20 30 FEMQYCWSHS GVCRDKSERN NKPMAWTYCE NRQKKCEF

References

[1]

"Solution structure of a defensin-like peptide from platypus venom." Torres A.M., Wang X., Fletcher J.I., Alewood D., Alewood P.F., Smith R., Simpson R.J., Nicholson G.M., Sutherland S.K., Gallagher C.H., King G.F., Kuchel P.W. Biochem. J. 341:785-794(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Venom and Venom gland.

Web resources

Protein Spotlight

Platypus poison - Issue 29 of December 2002

Cross-references

3D structure databases
ProteinModelPortal	P82141.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012553. Defensin_3. [Graphical view]
Pfam	PF08131. Defensin_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLP3_ORNAN

Accession

Primary (citable) accession number: P82141

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Annotation program

Animal Toxin Annotation Program