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P82140

- DLP2_ORNAN

UniProt

P82140 - DLP2_ORNAN

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Protein

Defensin-like peptide 2/4

Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.1 Publication

GO - Biological processi

  1. pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like peptide 2/4
Short name:
DLP-2/DLP-4
Alternative name(s):
Ornithorhynchus venom defensin-like peptide B
Short name:
OvDLP-B
OrganismiOrnithorhynchus anatinus (Duckbill platypus)
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
ProteomesiUP000002279: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 2422 PublicationsPRO_0000352673
Chaini25 – 6642Defensin-like peptide 2/4PRO_0000079933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261D-methionine; in form DLP-21 Publication
Disulfide bondi33 ↔ 63
Disulfide bondi40 ↔ 56
Disulfide bondi48 ↔ 64

Post-translational modificationi

Stereoinversion of L-Met-26 (in DLP-4) to D-Met-26 (in DLP-2).1 Publication

Keywords - PTMi

D-amino acid, Disulfide bond

Expressioni

Tissue specificityi

Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including brain, intestine, kidney, lung, spleen and testis.3 Publications

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 323
Helixi33 – 364
Beta strandi39 – 424
Beta strandi53 – 553
Beta strandi61 – 644

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D6BNMR-A25-66[»]
1ZUENMR-A25-66[»]
1ZUFNMR-A25-66[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82140.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107815.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF08131. Defensin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82140-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLAYLLLLL VAVLFQAGGG SAKPIMFFEM QACWSHSGVC RDKSERNCKP
60
MAWTYCENRN QKCCEY
Length:66
Mass (Da):7,599
Last modified:October 14, 2008 - v2
Checksum:i1825CB894D077B7B
GO

Genome annotation databases

EnsembliENSOANT00000002832; ENSOANP00000002831; ENSOANG00000001779.

Cross-referencesi

Web resourcesi

Platypus resources
Protein Spotlight

Platypus poison - Issue 29 of December 2002

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D6B NMR - A 25-66 [» ]
1ZUE NMR - A 25-66 [» ]
1ZUF NMR - A 25-66 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOANT00000002832 ; ENSOANP00000002831 ; ENSOANG00000001779 .

Phylogenomic databases

HOVERGENi HBG107815.

Miscellaneous databases

EvolutionaryTracei P82140.

Family and domain databases

Gene3Di 2.20.20.10. 1 hit.
InterProi IPR012553. Defensin_3.
IPR023355. Myo_neuro_toxin.
[Graphical view ]
Pfami PF08131. Defensin_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected."
    Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.
    Toxicon 52:559-565(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: PROTEIN SEQUENCE OF 25-66, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, STRUCTURE BY NMR OF 25-66.
    Tissue: Venom and Venom gland.
  3. "Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold."
    Torres A.M., de Plater G.M., Doverskog M., Birinyi-Strachan L.C., Nicholson G.M., Gallagher C.H., Kuchel P.W.
    Biochem. J. 348:649-656(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-66, STRUCTURE BY NMR OF 25-66.
    Tissue: Venom.
  4. "D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties."
    Torres A.M., Tsampazi C., Geraghty D.P., Bansal P.S., Alewood P.F., Kuchel P.W.
    Biochem. J. 391:215-220(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: D-AMINO ACID AT MET-26, TISSUE SPECIFICITY, STRUCTURE BY NMR OF 25-66.

Entry informationi

Entry nameiDLP2_ORNAN
AccessioniPrimary (citable) accession number: P82140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: October 1, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3