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Protein

Defensin-like peptide 2/4

Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.1 Publication

GO - Molecular functioni

GO - Biological processi

  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like peptide 2/41 Publication
Short name:
DLP-2/DLP-41 Publication
Alternative name(s):
Ornithorhynchus venom defensin-like peptide B1 Publication
Short name:
OvDLP-B1 Publication
OrganismiOrnithorhynchus anatinus (Duckbill platypus)
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000035267323 – 242 Publications2
ChainiPRO_000007993325 – 66Defensin-like peptide 2/4Add BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26D-methionine; in form DLP-21 Publication1
Disulfide bondi33 ↔ 633 PublicationsImported
Disulfide bondi40 ↔ 563 PublicationsImported
Disulfide bondi48 ↔ 643 PublicationsImported

Post-translational modificationi

Stereoinversion of L-Met-26 (in DLP-4) to D-Met-26 (in DLP-2).1 Publication

Keywords - PTMi

D-amino acid, Disulfide bond

Expressioni

Tissue specificityi

Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including brain, intestine, kidney, lung, spleen and testis.3 Publications

Gene expression databases

BgeeiENSOANG00000001779.

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 32Combined sources3
Helixi33 – 36Combined sources4
Beta strandi39 – 42Combined sources4
Beta strandi53 – 55Combined sources3
Beta strandi61 – 64Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D6BNMR-A25-66[»]
1ZUENMR-A25-66[»]
1ZUFNMR-A25-66[»]
SMRiP82140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82140.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107815.
OrthoDBiEOG091G1945.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiView protein in InterPro
IPR012553. Defensin_3.
IPR023355. Myo_ane_neurotoxin_sf.
PfamiView protein in Pfam
PF08131. Defensin_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAYLLLLL VAVLFQAGGG SAKPIMFFEM QACWSHSGVC RDKSERNCKP
60
MAWTYCENRN QKCCEY
Length:66
Mass (Da):7,599
Last modified:October 14, 2008 - v2
Checksum:i1825CB894D077B7B
GO

Genome annotation databases

EnsembliENSOANT00000002832; ENSOANP00000002831; ENSOANG00000001779.

Similar proteinsi

Entry informationi

Entry nameiDLP2_ORNAN
AccessioniPrimary (citable) accession number: P82140
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries