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P82140

- DLP2_ORNAN

UniProt

P82140 - DLP2_ORNAN

Protein

Defensin-like peptide 2/4

Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.1 Publication

    GO - Biological processi

    1. pathogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Defensin-like peptide 2/4
    Short name:
    DLP-2/DLP-4
    Alternative name(s):
    Ornithorhynchus venom defensin-like peptide B
    Short name:
    OvDLP-B
    OrganismiOrnithorhynchus anatinus (Duckbill platypus)
    Taxonomic identifieri9258 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
    ProteomesiUP000002279: Unplaced

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 2422 PublicationsPRO_0000352673
    Chaini25 – 6642Defensin-like peptide 2/4PRO_0000079933Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261D-methionine; in form DLP-21 Publication
    Disulfide bondi33 ↔ 63
    Disulfide bondi40 ↔ 56
    Disulfide bondi48 ↔ 64

    Post-translational modificationi

    Stereoinversion of L-Met-26 (in DLP-4) to D-Met-26 (in DLP-2).1 Publication

    Keywords - PTMi

    D-amino acid, Disulfide bond

    Expressioni

    Tissue specificityi

    Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including brain, intestine, kidney, lung, spleen and testis.3 Publications

    Structurei

    Secondary structure

    1
    66
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 323
    Helixi33 – 364
    Beta strandi39 – 424
    Beta strandi53 – 553
    Beta strandi61 – 644

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D6BNMR-A25-66[»]
    1ZUENMR-A25-66[»]
    1ZUFNMR-A25-66[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP82140.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG107815.

    Family and domain databases

    Gene3Di2.20.20.10. 1 hit.
    InterProiIPR012553. Defensin_3.
    IPR023355. Myo_neuro_toxin.
    [Graphical view]
    PfamiPF08131. Defensin_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P82140-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLAYLLLLL VAVLFQAGGG SAKPIMFFEM QACWSHSGVC RDKSERNCKP   50
    MAWTYCENRN QKCCEY 66
    Length:66
    Mass (Da):7,599
    Last modified:October 14, 2008 - v2
    Checksum:i1825CB894D077B7B
    GO

    Genome annotation databases

    EnsembliENSOANT00000002832; ENSOANP00000002831; ENSOANG00000001779.

    Cross-referencesi

    Web resourcesi

    Platypus resources
    Protein Spotlight

    Platypus poison - Issue 29 of December 2002

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D6B NMR - A 25-66 [» ]
    1ZUE NMR - A 25-66 [» ]
    1ZUF NMR - A 25-66 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOANT00000002832 ; ENSOANP00000002831 ; ENSOANG00000001779 .

    Phylogenomic databases

    HOVERGENi HBG107815.

    Miscellaneous databases

    EvolutionaryTracei P82140.

    Family and domain databases

    Gene3Di 2.20.20.10. 1 hit.
    InterProi IPR012553. Defensin_3.
    IPR023355. Myo_neuro_toxin.
    [Graphical view ]
    Pfami PF08131. Defensin_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected."
      Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.
      Toxicon 52:559-565(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Cited for: PROTEIN SEQUENCE OF 25-66, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, STRUCTURE BY NMR OF 25-66.
      Tissue: Venom and Venom gland.
    3. "Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold."
      Torres A.M., de Plater G.M., Doverskog M., Birinyi-Strachan L.C., Nicholson G.M., Gallagher C.H., Kuchel P.W.
      Biochem. J. 348:649-656(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-66, STRUCTURE BY NMR OF 25-66.
      Tissue: Venom.
    4. "D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties."
      Torres A.M., Tsampazi C., Geraghty D.P., Bansal P.S., Alewood P.F., Kuchel P.W.
      Biochem. J. 391:215-220(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: D-AMINO ACID AT MET-26, TISSUE SPECIFICITY, STRUCTURE BY NMR OF 25-66.

    Entry informationi

    Entry nameiDLP2_ORNAN
    AccessioniPrimary (citable) accession number: P82140
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3