Reviewed, UniProtKB/Swiss-Prot P82103 (MYNA_MYTGA)

Names and origin

Protein names	Recommended name:     Myticin-A
Organism	Mytilus galloprovincialis (Mediterranean mussel)
Taxonomic identifier	29158 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Mollusca › Bivalvia › Pteriomorphia › Mytiloida › Mytiloidea › Mytilidae › Mytilinae › Mytilus

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Bacteriolytic activity against Gram-positive bacteria M.luteus, B.megaterium and A.viridans.
Subcellular location	Secreted.
Tissue specificity	Hemocytes.
Post-translational modification	Contains four disulfide bonds.
Mass spectrometry	Molecular mass is 4437.45 Da from positions 21 - 60. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.1
	Peptide	21 – 60	40	Myticin-A		PRO_0000004994
	Propeptide	61 – 96	36	Removed in mature form		PRO_0000004995

Sequences

	Sequence		Length	Mass (Da)
	P82103-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0C7B1CC353E5C2B0	FASTA	96	10,556
	10 20 30 40 50 60 MKATILLAVL VAVFVAGTEA HSHACTSYWC GKFCGTASCT HYLCRVLHPG KMCACVHCSR 70 80 90 VNNPFRVNQV AKSINDLDYT PIMKSMENLD NGMDML

References

[1]

"Myticin, a novel cysteine-rich antimicrobial peptide isolated from hemocytes and plasma of the mussel Mytilus galloprovincialis." Mitta G., Hubert F., Noel T., Roch P. Eur. J. Biochem. 265:71-78(1999) [PubMed: 10491159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-56, MASS SPECTROMETRY. Tissue: Hemocyte and Plasma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF162334 mRNA. Translation: AAD47638.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR019631. Myticin_preproprotein. [Graphical view]
Pfam	PF10690. Myticin-prepro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYNA_MYTGA

Accession

Primary (citable) accession number: P82103

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)