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P82094

- TMF1_HUMAN

UniProt

P82094 - TMF1_HUMAN

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Protein
TATA element modulatory factor
Gene
TMF1, ARA160
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).4 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. transcription cofactor activity Source: ProtInc

GO - Biological processi

  1. Leydig cell differentiation Source: Ensembl
  2. acrosome assembly Source: Ensembl
  3. cellular response to organic cyclic compound Source: Ensembl
  4. defense response to bacterium Source: Ensembl
  5. luteinizing hormone secretion Source: Ensembl
  6. negative regulation of apoptotic process Source: Ensembl
  7. negative regulation of gene expression Source: Ensembl
  8. positive regulation of cytokine production Source: Ensembl
  9. positive regulation of testosterone secretion Source: Ensembl
  10. regulation of proteasomal protein catabolic process Source: UniProtKB
  11. regulation of transcription, DNA-templated Source: ProtInc
  12. sperm motility Source: Ensembl
  13. spermatid nucleus differentiation Source: Ensembl
  14. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA element modulatory factor
Short name:
TMF
Alternative name(s):
Androgen receptor coactivator 160 kDa protein
Androgen receptor-associated protein of 160 kDa
Gene namesi
Name:TMF1
Synonyms:ARA160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11870. TMF1.

Subcellular locationi

Cytoplasm. Nucleus. Golgi apparatus membrane
Note: Concentrated at the budding structures localized at the tips of cisternae.2 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. Golgi membrane Source: UniProtKB-SubCell
  3. endoplasmic reticulum Source: Ensembl
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi333 – 3353SLD → AAA: Strongly reduced the ubiquitination directing activity of the protein. 1 Publication

Organism-specific databases

PharmGKBiPA36571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10931093TATA element modulatory factor
PRO_0000072589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Phosphoserine1 Publication
Modified residuei77 – 771Phosphoserine2 Publications
Modified residuei112 – 1121Phosphoserine1 Publication
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei328 – 3281Phosphoserine2 Publications
Modified residuei338 – 3381Phosphoserine1 Publication
Modified residuei344 – 3441Phosphoserine4 Publications
Modified residuei925 – 9251Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by FER By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP82094.
PaxDbiP82094.
PRIDEiP82094.

PTM databases

PhosphoSiteiP82094.

Expressioni

Inductioni

Down-regulated in malignant brain tumors.1 Publication

Gene expression databases

ArrayExpressiP82094.
BgeeiP82094.
CleanExiHS_TMF1.
GenevestigatoriP82094.

Organism-specific databases

HPAiHPA008729.

Interactioni

Subunit structurei

Interacts with TRNP1; may regulate TRNP1 proteasomal degradation By similarity. Component of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NR3C1P041503EBI-949763,EBI-493507

Protein-protein interaction databases

BioGridi112965. 9 interactions.
DIPiDIP-5933N.
IntActiP82094. 6 interactions.
MINTiMINT-2863632.
STRINGi9606.ENSP00000381567.

Structurei

3D structure databases

ProteinModelPortaliP82094.
SMRiP82094. Positions 473-515.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni333 – 34210Interaction with Elongin BC complex

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili439 – 922484 Reviewed prediction
Add
BLAST
Coiled coili984 – 1092109 Reviewed prediction
Add
BLAST

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG127593.
HOGENOMiHOG000154639.
HOVERGENiHBG016599.
OMAiSWFNASQ.
OrthoDBiEOG7X0VHV.
PhylomeDBiP82094.
TreeFamiTF329420.

Family and domain databases

InterProiIPR022092. TMF_DNA-bd.
IPR022091. TMF_TATA-bd.
[Graphical view]
PfamiPF12329. TMF_DNA_bd. 1 hit.
PF12325. TMF_TATA_bd. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P82094-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSIWAE TIPYGEPGIS     50
SPVSGGWDTS TWGLKSNTEP QSPPIASPKA ITKPVRRTVV DESENFFSAF 100
LSPTDVQTIQ KSPVVSKPPA KSQRPEEEVK SSLHESLHIG QSRTPETTES 150
QVKDSSLCVS GETLAAGTSS PKTEGKHEET VNKESDMKVP TVSLKVSESV 200
IDVKTTMESI SNTSTQSLTA ETKDIALEPK EQKHEDRQSN TPSPPVSTFS 250
SGTSTTSDIE VLDHESVISE SSASSRQETT DSKSSLHLMQ TSFQLLSASA 300
CPEYNRLDDF QKLTESCCSS DAFERIDSFS VQSLDSRSVS EINSDDELSG 350
KGYALVPIIV NSSTPKSKTV ESAEGKSEEV NETLVIPTEE AEMEESGRSA 400
TPVNCEQPDI LVSSTPINEG QTVLDKVAEQ CEPAESQPEA LSEKEDVCKT 450
VEFLNEKLEK REAQLLSLSK EKALLEEAFD NLKDEMFRVK EESSSISSLK 500
DEFTQRIAEA EKKVQLACKE RDAAKKEIKN IKEELATRLN SSETADLLKE 550
KDEQIRGLME EGEKLSKQQL HNSNIIKKLR AKDKENENMV AKLNKKVKEL 600
EEELQHLKQV LDGKEEVEKQ HRENIKKLNS MVERQEKDLG RLQVDMDELE 650
EKNRSIQAAL DSAYKELTDL HKANAAKDSE AQEAALSREM KAKEELSAAL 700
EKAQEEARQQ QETLAIQVGD LRLALQRTEQ AAARKEDYLR HEIGELQQRL 750
QEAENRNQEL SQSVSSTTRP LLRQIENLQA TLGSQTSSWE KLEKNLSDRL 800
GESQTLLAAA VERERAATEE LLANKIQMSS MESQNSLLRQ ENSRFQAQLE 850
SEKNRLCKLE DENNRYQVEL ENLKDEYVRT LEETRKEKTL LNSQLEMERM 900
KVEQERKKAI FTQETIKEKE RKPFSVSSTP TMSRSSSISG VDMAGLQTSF 950
LSQDESHDHS FGPMPISANG SNLYDAVRMG AGSSIIENLQ SQLKLREGEI 1000
THLQLEIGNL EKTRSIMAEE LVKLTNQNDE LEEKVKEIPK LRTQLRDLDQ 1050
RYNTILQMYG EKAEEAEELR LDLEDVKNMY KTQIDELLRQ SLS 1093
Length:1,093
Mass (Da):122,842
Last modified:December 16, 2008 - v2
Checksum:i566BBE3EC36EF11C
GO
Isoform 2 (identifier: P82094-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-449: K → KVTL

Show »
Length:1,096
Mass (Da):123,155
Checksum:iA539A619EE47842D
GO

Sequence cautioni

The sequence AAD54608.1 differs from that shown. Reason: Frameshift at positions 969, 971, 975 and 985.
The sequence BAD92346.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti430 – 4301Q → E.
Corresponds to variant rs35447207 [ dbSNP | Ensembl ].
VAR_051439
Natural varianti448 – 4481C → Y.
Corresponds to variant rs34428015 [ dbSNP | Ensembl ].
VAR_051440
Natural varianti682 – 6821Q → R.
Corresponds to variant rs3736422 [ dbSNP | Ensembl ].
VAR_051441
Natural varianti798 – 7981D → H.
Corresponds to variant rs1532918 [ dbSNP | Ensembl ].
VAR_024284

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei449 – 4491K → KVTL in isoform 2.
VSP_037411

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01042 mRNA. Translation: AAD54608.1. Frameshift.
AB209109 mRNA. Translation: BAD92346.1. Different initiation.
AC109587 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65468.1.
BC117418 mRNA. Translation: AAI17419.1.
BC126123 mRNA. Translation: AAI26124.1.
BC143840 mRNA. Translation: AAI43841.1.
CCDSiCCDS43105.1. [P82094-1]
PIRiA47212.
RefSeqiNP_009045.2. NM_007114.2. [P82094-1]
UniGeneiHs.267632.

Genome annotation databases

EnsembliENST00000398559; ENSP00000381567; ENSG00000144747. [P82094-1]
ENST00000543976; ENSP00000438706; ENSG00000144747. [P82094-2]
GeneIDi7110.
KEGGihsa:7110.
UCSCiuc003dnn.3. human. [P82094-1]
uc011bfx.2. human. [P82094-2]

Polymorphism databases

DMDMi218511858.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01042 mRNA. Translation: AAD54608.1 . Frameshift.
AB209109 mRNA. Translation: BAD92346.1 . Different initiation.
AC109587 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65468.1 .
BC117418 mRNA. Translation: AAI17419.1 .
BC126123 mRNA. Translation: AAI26124.1 .
BC143840 mRNA. Translation: AAI43841.1 .
CCDSi CCDS43105.1. [P82094-1 ]
PIRi A47212.
RefSeqi NP_009045.2. NM_007114.2. [P82094-1 ]
UniGenei Hs.267632.

3D structure databases

ProteinModelPortali P82094.
SMRi P82094. Positions 473-515.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112965. 9 interactions.
DIPi DIP-5933N.
IntActi P82094. 6 interactions.
MINTi MINT-2863632.
STRINGi 9606.ENSP00000381567.

PTM databases

PhosphoSitei P82094.

Polymorphism databases

DMDMi 218511858.

Proteomic databases

MaxQBi P82094.
PaxDbi P82094.
PRIDEi P82094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398559 ; ENSP00000381567 ; ENSG00000144747 . [P82094-1 ]
ENST00000543976 ; ENSP00000438706 ; ENSG00000144747 . [P82094-2 ]
GeneIDi 7110.
KEGGi hsa:7110.
UCSCi uc003dnn.3. human. [P82094-1 ]
uc011bfx.2. human. [P82094-2 ]

Organism-specific databases

CTDi 7110.
GeneCardsi GC03M069068.
HGNCi HGNC:11870. TMF1.
HPAi HPA008729.
MIMi 601126. gene.
neXtProti NX_P82094.
PharmGKBi PA36571.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG127593.
HOGENOMi HOG000154639.
HOVERGENi HBG016599.
OMAi SWFNASQ.
OrthoDBi EOG7X0VHV.
PhylomeDBi P82094.
TreeFami TF329420.

Miscellaneous databases

ChiTaRSi TMF1. human.
GeneWikii TMF1.
GenomeRNAii 7110.
NextBioi 27831.
PROi P82094.
SOURCEi Search...

Gene expression databases

ArrayExpressi P82094.
Bgeei P82094.
CleanExi HS_TMF1.
Genevestigatori P82094.

Family and domain databases

InterProi IPR022092. TMF_DNA-bd.
IPR022091. TMF_TATA-bd.
[Graphical view ]
Pfami PF12329. TMF_DNA_bd. 1 hit.
PF12325. TMF_TATA_bd. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor."
    Garcia J.A., Ou S.-H.I., Wu F., Lusis A.J., Sparkes R.S., Gaynor R.B.
    Proc. Natl. Acad. Sci. U.S.A. 89:9372-9376(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Tissue: Cervix carcinoma.
  2. "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells."
    Hsiao P.W., Chang C.
    J. Biol. Chem. 274:22373-22379(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno F.R.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  7. "A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus."
    Mori K., Kato H.
    FEBS Lett. 520:127-132(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN SWI/SNF COMPLEXES.
  8. "TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3."
    Perry E., Tsruya R., Levitsky P., Pomp O., Taller M., Weisberg S., Parris W., Kulkarni S., Malovani H., Pawson T., Shpungin S., Nir U.
    Oncogene 23:8908-8919(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 333-LEU--ASP-335, INTERACTION WITH TCEB1 AND STAT3, INDUCTION.
  9. "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic."
    Yamane J., Kubo A., Nakayama K., Yuba-Kubo A., Katsuno T., Tsukita S., Tsukita S.
    Exp. Cell Res. 313:3472-3485(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB6A.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-77; SER-112; SER-328; SER-338; SER-344 AND SER-925, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-328 AND SER-344, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217 AND SER-344, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMF1_HUMAN
AccessioniPrimary (citable) accession number: P82094
Secondary accession number(s): B7ZLJ2, Q17R87, Q59GK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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