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Protein

Beta-defensin 2

Gene

Defb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Has bactericidal activity.By similarity

GO - Biological processi

  • defense response to bacterium Source: MGI

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 2
Short name:
BD-2
Short name:
mBD-2
Alternative name(s):
Defensin, beta 2
Gene namesi
Name:Defb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338754. Defb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PeptideiPRO_000000692721 – 71Beta-defensin 2Add BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP82020.
PRIDEiP82020.

Expressioni

Tissue specificityi

Kidney, uterus and to a lesser extent in heart.1 Publication

Inductioni

In tracheal epithelium, by lipopolysaccharide or inflammation.1 Publication

Gene expression databases

BgeeiENSMUSG00000006570.
CleanExiMM_DEFB2.
ExpressionAtlasiP82020. baseline and differential.
GenevisibleiP82020. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006745.

Structurei

3D structure databases

ProteinModelPortaliP82020.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00900000142745.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiP82020.
OMAiICPPSAR.
OrthoDBiEOG091G18R7.
PhylomeDBiP82020.

Family and domain databases

InterProiView protein in InterPro
IPR001855. Defensin_beta-typ.
PfamiView protein in Pfam
PF00711. Defensin_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLCSLLLI CCLLFSYTTP AVGSLKSIGY EAELDHCHTN GGYCVRAICP
60 70
PSARRPGSCF PEKNPCCKYM K
Length:71
Mass (Da):7,820
Last modified:November 1, 1999 - v1
Checksum:i504A40E6369B3A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011800 mRNA. Translation: CAB42815.1.
CCDSiCCDS40284.1.
RefSeqiNP_034160.1. NM_010030.1.
UniGeneiMm.41981.

Genome annotation databases

EnsembliENSMUST00000006745; ENSMUSP00000006745; ENSMUSG00000006570.
GeneIDi13215.
KEGGimmu:13215.
UCSCiuc009lca.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDEFB2_MOUSE
AccessioniPrimary (citable) accession number: P82020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families