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P81943

- ALL5_APIGR

UniProt

P81943 - ALL5_APIGR

Protein

Allergen Api g 5

Gene
N/A
Organism
Apium graveolens (Celery)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cofactori

    FAD.By similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    GO - Biological processi

    1. type I hypersensitivity Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Allergen Api g 5
    Alternative name(s):
    Allergen: Api g 5
    OrganismiApium graveolens (Celery)
    Taxonomic identifieri4045 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeapioid supercladeApieaeApium

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE. The glycan moiety seems to constitute the relevant allergenic epitope.2 Publications

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3087. Api g 5.0101.
    44. Api g 5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›86›86Allergen Api g 5PRO_0000128175Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Carries MUXF and MMXF, two complex N-linked glycans with alpha-1,3-fucose and beta-1,2-xylose residues in their structures. MMXF is added to Asn-62.1 Publication

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the oxygen-dependent FAD-linked oxidoreductase family.Sequence Analysis

    Sequencei

    Sequence statusi: Fragments.

    P81943-1 [UniParc]FASTAAdd to Basket

    « Hide

    LPNPSGFVTC LSSISKSVYT PAINLKAVIA DPVAKTAVVQ AGATLGEVYY   50
    XIIYARVLWV GNTTQKLEWI RSLHDYQSSF FPFFSA 86
    Length:86
    Mass (Da):9,441
    Last modified:July 25, 2003 - v3
    Checksum:i09F5C64FA7ACD452
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi22 – 2321 Publication
    Non-adjacent residuesi52 – 5321 Publication
    Non-adjacent residuesi76 – 7721 Publication
    Non-terminal residuei86 – 8611 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3087. Api g 5.0101.
    44. Api g 5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE OF 1-18, ALLERGEN.
      Tissue: Tuber1 Publication.
    2. "Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients."
      Bublin M., Radauer C., Wilson I.B.H., Kraft D., Scheiner O., Breiteneder H., Hoffmann-Sommergruber K.
      FASEB J. 17:1697-1699(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-86, SEQUENCE REVISION, GLYCOSYLATION, ALLERGEN.
      Tissue: Tuber1 Publication.

    Entry informationi

    Entry nameiALL5_APIGR
    AccessioniPrimary (citable) accession number: P81943
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: July 25, 2003
    Last modified: October 1, 2014
    This is version 40 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    The order of the peptides shown is unknown.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3