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P81943 (ALL5_APIGR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Allergen Api g 5
Alternative name(s):
Allergen=Api g 5
OrganismApium graveolens (Celery)
Taxonomic identifier4045 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeapioid supercladeApieaeApium

Protein attributes

Sequence length86 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

FAD By similarity. UniProtKB P93479

Post-translational modification

Carries MUXF and MMXF, two complex N-linked glycans with alpha-1,3-fucose and beta-1,2-xylose residues in their structures. MMXF is added to Asn-62. Ref.2

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. The glycan moiety seems to constitute the relevant allergenic epitope. Ref.1 Ref.2

Sequence similarities

Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

Caution

The order of the peptides shown is unknown. Ref.2

Ontologies

Keywords
   DiseaseAllergen
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMGlycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processtype I hypersensitivity

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›86›86Allergen Api g 5
PRO_0000128175

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Ref.2

Experimental info

Non-adjacent residues22 – 232
Non-adjacent residues52 – 532
Non-adjacent residues76 – 772
Non-terminal residue861

Sequences

Sequence LengthMass (Da)Tools
P81943 [UniParc].

Last modified July 25, 2003. Version 3.
Checksum: 09F5C64FA7ACD452

FASTA869,441
        10         20         30         40         50         60 
LPNPSGFVTC LSSISKSVYT PAINLKAVIA DPVAKTAVVQ AGATLGEVYY XIIYARVLWV 

        70         80 
GNTTQKLEWI RSLHDYQSSF FPFFSA 

« Hide

References

[1]"N-terminal sequences of high molecular weight allergens from celery tuber."
Ganglberger E., Radauer C., Grimm R., Hoffmann-Sommergruber K., Breiteneder H., Scheiner O., Jensen-Jarolim E.
Clin. Exp. Allergy 30:566-570(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-18, ALLERGEN.
Tissue: Tuber.
[2]"Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients."
Bublin M., Radauer C., Wilson I.B.H., Kraft D., Scheiner O., Breiteneder H., Hoffmann-Sommergruber K.
FASEB J. 17:1697-1699(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-86, SEQUENCE REVISION, GLYCOSYLATION, ALLERGEN.
Tissue: Tuber.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3087. Api g 5.0101.
44. Api g 5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameALL5_APIGR
AccessionPrimary (citable) accession number: P81943
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: July 25, 2003
Last modified: February 19, 2014
This is version 39 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries