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P81942 (GSTP1_BUFBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase P 1

EC=2.5.1.18
Alternative name(s):
BBGSTP1-1
GST class-pi
OrganismBufo bufo (European toad)
Taxonomic identifier8384 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeBufo

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm By similarity. Mitochondrion By similarity. Nucleus By similarity. Note: The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization By similarity.

Sequence similarities

Belongs to the GST superfamily. Pi family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Mitochondrion
Nucleus
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Glutathione S-transferase P 1
PRO_0000185908

Regions

Domain1 – 8080GST N-terminal
Domain82 – 203122GST C-terminal
Region51 – 522Glutathione binding By similarity
Region64 – 652Glutathione binding By similarity

Sites

Binding site71Glutathione By similarity
Binding site131Glutathione By similarity
Binding site381Glutathione By similarity
Binding site441Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P81942 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: AC835C0390F3A71D

FASTA21023,820
        10         20         30         40         50         60 
PEYTIIYFNA RGRCEAMRML MADQGAQWKE EVVTSDDWQK GDLKKAAVYG QLPGFKDGDF 

        70         80         90        100        110        120 
TLYQSNAMLR LLARNHDLYG KNPREASLID MVNDGVEDLR LKYLKMIYQN YENGKDDYVK 

       130        140        150        160        170        180 
ALPTNLGHFE RLLASNNEGK GFVVGAHISF ADYNLVDLLH NHLVLAPDCL SGFPLLCAYV 

       190        200        210 
KRISSRPKLE AYLSSDAHKK RPINGNGKQQ 

« Hide

References

[1]"Amphibian embryo glutathione transferase: amino acid sequence and structural properties."
Sacchetta P., Petruzzelli R., Melino S., Bucciarelli T., Pennelli A., Amicarelli F., Miranda M., Di Ilio C.
Biochem. J. 322:679-680(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Embryo.

Cross-references

3D structure databases

ProteinModelPortalP81942.
SMRP81942. Positions 1-209.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108324.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01268. GSTRNSFRASEP.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTP1_BUFBU
AccessionPrimary (citable) accession number: P81942
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families