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P81922 (OR47B_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Odorant receptor 47b
Gene names
Name:Or47b
Synonyms:DOR47E.2, Or47E.2
ORF Names:CG13206
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide By similarity.

Subunit structure

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in the antenna. Ref.3

Miscellaneous

The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

Sequence similarities

Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Odorant receptor 47b
PRO_0000174251

Regions

Topological domain1 – 7474Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=1; Potential
Topological domain96 – 1038Extracellular Potential
Transmembrane104 – 12421Helical; Name=2; Potential
Topological domain125 – 16945Cytoplasmic Potential
Transmembrane170 – 19021Helical; Name=3; Potential
Topological domain191 – 22939Extracellular Potential
Transmembrane230 – 25021Helical; Name=4; Potential
Topological domain251 – 30252Cytoplasmic Potential
Transmembrane303 – 32321Helical; Name=5; Potential
Topological domain324 – 3307Extracellular Potential
Transmembrane331 – 35121Helical; Name=6; Potential
Topological domain352 – 38938Cytoplasmic Potential
Transmembrane390 – 41021Helical; Name=7; Potential
Topological domain411 – 4122Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
P81922 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: F49279703127DB3F

FASTA41247,913
        10         20         30         40         50         60 
MNDSGYQSNL SLLRVFLDEF RSVLRQESPG LIPRLAFYYV RAFLSLLCQY PNKKLASLPL 

        70         80         90        100        110        120 
YRWINLFIMC NVMTIFWTMF VALPESKNVI EMGDDLVWIS GMALVFTKIF YMHLRCDEID 

       130        140        150        160        170        180 
ELISDFEYYN RELRPHNIDE EVLGWQRLCY VIESGLYINC FCLVNFFSAA IFLQPLLGEG 

       190        200        210        220        230        240 
KLPFHSVYPF QWHRLDLHPY TFWFLYIWQS LTSQHNLMSI LMVDMVGIST FLQTALNLKL 

       250        260        270        280        290        300 
LCIEIRKLGD MEVSDKRFHE EFCRVVRFHQ HIIKLVGKAN RAFNGAFNAQ LMASFSLISI 

       310        320        330        340        350        360 
STFETMAAAA VDPKMAAKFV LLMLVAFIQL SLWCVSGTLV YTQSVEVAQA AFDINDWHTK 

       370        380        390        400        410 
SPGIQRDISF VILRAQKPLM YVAEPFLPFT LGTYMLVLKN CYRLLALMQE SM

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila."
Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.
Neuron 22:327-338(1999) [PubMed: 10069338] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013599 Genomic DNA. Translation: AAF58667.3.
RefSeqNP_523690.3. NM_078966.3.
UniGeneDm.26901.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP81922.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0088166; FBpp0087262; FBgn0026385.
GeneID36212.
KEGGdme:Dmel_CG13206.
NMPDRfig|7227.3.peg.4629.

Organism-specific databases

CTD36212.
FlyBaseFBgn0026385. Or47b.

Phylogenomic databases

eggNOGinNOG10124.
GeneTreeEMGT00050000009332.
InParanoidP81922.
OMATFETMAA.
OrthoDBEOG4QNKBJ.
PhylomeDBP81922.

Gene expression databases

BgeeP81922.
GermOnlineCG13206. Drosophila melanogaster.

Family and domain databases

InterProIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
KOK08471.
PANTHERPTHR21137. 7tm6_olfct_rcpt. 1 hit.
PfamPF02949. 7tm_6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio797364.

Entry information

Entry nameOR47B_DROME
AccessionPrimary (citable) accession number: P81922
Secondary accession number(s): Q9V5X4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 24, 2004
Last modified: January 25, 2012
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents