P81917 (OR43A_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 92.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Odorant receptor 43a | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Ref.6 |
| Subunit structure | Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway. Ref.6 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity. |
| Tissue specificity | Expressed with Orco in 20 sensory neurons on the distal edge of the antenna. Ref.1 Ref.5 Ref.6 |
| Miscellaneous | The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways. |
| Sequence similarities | Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Olfaction Sensory transduction |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Non-traceable author statement Ref.5Ref.1. Source: UniProtKB plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW odorant bindingTraceable author statement. Source: FlyBase olfactory receptor activityNon-traceable author statement Ref.5Ref.1. Source: UniProtKB protein bindingInferred from physical interaction Ref.6. Source: FlyBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 376 | 376 | Odorant receptor 43a | PRO_0000174244 | |||||
Regions | |||||||||
| Topological domain | 1 – 32 | 32 | Cytoplasmic Potential | ||||||
| Transmembrane | 33 – 53 | 21 | Helical; Name=1; Potential | ||||||
| Topological domain | 54 – 58 | 5 | Extracellular Potential | ||||||
| Transmembrane | 59 – 79 | 21 | Helical; Name=2; Potential | ||||||
| Topological domain | 80 – 123 | 44 | Cytoplasmic Potential | ||||||
| Transmembrane | 124 – 144 | 21 | Helical; Name=3; Potential | ||||||
| Topological domain | 145 – 178 | 34 | Extracellular Potential | ||||||
| Transmembrane | 179 – 199 | 21 | Helical; Name=4; Potential | ||||||
| Topological domain | 200 – 247 | 48 | Cytoplasmic Potential | ||||||
| Transmembrane | 248 – 268 | 21 | Helical; Name=5; Potential | ||||||
| Topological domain | 269 – 276 | 8 | Extracellular Potential | ||||||
| Transmembrane | 277 – 297 | 21 | Helical; Name=6; Potential | ||||||
| Topological domain | 298 – 342 | 45 | Cytoplasmic Potential | ||||||
| Transmembrane | 343 – 363 | 21 | Helical; Name=7; Potential | ||||||
| Topological domain | 364 – 376 | 13 | Extracellular Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 154 | 1 | L → V in AAD26361. Ref.1 | ||||||
| Sequence conflict | 237 – 272 | 36 | Missing Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A spatial map of olfactory receptor expression in the Drosophila antenna." Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R. Cell 96:725-736(1999) [PubMed: 10089887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Oregon-R. Tissue: Antenna. |
| [2] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [3] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley. |
| [4] | "Identification of candidate Drosophila olfactory receptors from genomic DNA sequence." Gao Q., Chess A. Genomics 60:31-39(1999) [PubMed: 10458908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-342. |
| [5] | "A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila." Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R. Neuron 22:327-338(1999) [PubMed: 10069338] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY. |
| [6] | "Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo." Benton R., Sachse S., Michnick S.W., Vosshall L.B. PLoS Biol. 4:E20-E20(2006) [PubMed: 16402857] [Abstract] Cited for: FUNCTION, INTERACTION WITH OR85B, TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF127926 mRNA. Translation: AAD26361.1. AE013599 Genomic DNA. Translation: AAF59280.1. |
| RefSeq | NP_523647.2. NM_078923.2. |
| UniGene | Dm.2588. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-29175N. |
| STRING | P81917. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0089051; FBpp0088122; FBgn0026389. |
| GeneID | 35644. |
| KEGG | dme:Dmel_CG1854. |
| NMPDR | fig|7227.3.peg.3605. |
Organism-specific databases | |
| CTD | 35644. |
| FlyBase | FBgn0026389. Or43a. |
Phylogenomic databases | |
| eggNOG | inNOG05706. |
| GeneTree | EMGT00050000009324. |
| InParanoid | P81917. |
| OMA | IFLMQTQ. |
| OrthoDB | EOG4573P9. |
| PhylomeDB | P81917. |
Gene expression databases | |
| Bgee | P81917. |
| GermOnline | CG1854. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR004117. 7tm6_olfct_rcpt. [Graphical view] |
| KO | K08471. |
| PANTHER | PTHR21137. 7tm6_olfct_rcpt. 1 hit. |
| Pfam | PF02949. 7tm_6. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 794402. |
Entry information
| Entry name | OR43A_DROME | ||||||||
| Accession | Primary (citable) accession number: P81917 Secondary accession number(s): Q9U6X4, Q9V4J0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with