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P81908

- CHLE_HORSE

UniProt

P81908 - CHLE_HORSE

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Protein
Cholinesterase
Gene
BCHE
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters By similarity.

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei198 – 1981Acyl-ester intermediate By similarity
Active sitei325 – 3251Charge relay system By similarity
Active sitei438 – 4381Charge relay system By similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB
  2. cholinesterase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
EQ-BCHE
Pseudocholinesterase
Gene namesi
Name:BCHE
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Cholinesterase
PRO_0000070285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)
Disulfide bondi65 ↔ 92 By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)
Modified residuei198 – 1981Phosphoserine By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...)
Disulfide bondi252 ↔ 263 By similarity
Glycosylationi256 – 2561N-linked (GlcNAc...)
Glycosylationi341 – 3411N-linked (GlcNAc...)
Disulfide bondi400 ↔ 519 By similarity
Glycosylationi455 – 4551N-linked (GlcNAc...)
Glycosylationi481 – 4811N-linked (GlcNAc...)
Glycosylationi486 – 4861N-linked (GlcNAc...)
Disulfide bondi571 – 571Interchain By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level). Present in most cells except erythrocytes.1 Publication

Interactioni

Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers By similarity.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000166.

Structurei

3D structure databases

ProteinModelPortaliP81908.
SMRiP81908. Positions 4-534, 536-567.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 1172Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2272.
HOVERGENiHBG008839.
InParanoidiP81908.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81908-1 [UniParc]FASTAAdd to Basket

« Hide

EEDIIITTKN GKVRGMNLPV LGGTVTAFLG IPYAQPPLGR LRFKKPQSLT    50
KWSNIWNATK YANSCYQNTD QSFPGFLGSE MWNPNTELSE DCLYLNVWIP 100
APKPKNATVM IWIYGGGFQT GTSSLPVYDG KFLARVERVI VVSMNYRVGA 150
LGFLALSENP EAPGNMGLFD QQLALQWVQK NIAAFGGNPR SVTLFGESAG 200
AASVSLHLLS PRSQPLFTRA ILQSGSSNAP WAVTSLYEAR NRTLTLAKRM 250
GCSRDNETEM IKCLRDKDPQ EILLNEVFVV PYDTLLSVNF GPTVDGDFLT 300
DMPDTLLQLG QFKRTQILVG VNKDEGTAFL VYGAPGFSKD NNSIITRKEF 350
QEGLKIFFPR VSEFGRESIL FHYMDWLDDQ RAENYREALD DVVGDYNIIC 400
PALEFTRKFS ELGNDAFFYY FEHRSTKLPW PEWMGVMHGY EIEFVFGLPL 450
ERRVNYTRAE EILSRSIMKR WANFAKYGNP NGTQNNSTRW PVFKSTEQKY 500
LTLNTESPKV YTKLRAQQCR FWTLFFPKVL ELTGNIDEAE REWKAGFHRW 550
NNYMMDWKNQ FNDYTSKKES CSDF 574
Length:574
Mass (Da):65,642
Last modified:May 1, 2000 - v1
Checksum:i07755EE9FB9CB33E
GO

Sequence databases

UniGeneiEca.13015.

Cross-referencesi

Sequence databases

UniGenei Eca.13015.

3D structure databases

ProteinModelPortali P81908.
SMRi P81908. Positions 4-534, 536-567.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000000166.

Chemistry

BindingDBi P81908.
ChEMBLi CHEMBL5763.

Protein family/group databases

MEROPSi S09.980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2272.
HOVERGENi HBG008839.
InParanoidi P81908.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
ProDomi PD415333. AChE_tetra. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of horse serum butyrycholinesterase."
    Moorad D.R., Luo C., Garcia G.E., Doctor B.P.
    (In) Doctor B.P., Taylor P., Quinn D.M., Rotundo R.L., Gentry M.K. (eds.); Structure and function of cholinesterases and related proteins, pp.145-146, Plenum Press, New York and London (1998)
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Plasma.

Entry informationi

Entry nameiCHLE_HORSE
AccessioniPrimary (citable) accession number: P81908
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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