Reviewed, UniProtKB/Swiss-Prot P81895 (ODO1_SOLTU)

Names and origin

Protein names	Recommended name:     2-oxoglutarate dehydrogenase E1 component     EC=1.2.4.2 Alternative name(s):     Alpha-ketoglutarate dehydrogenase     OGDC-E1
Organism	Solanum tuberosum (Potato)
Taxonomic identifier	4113 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length	19 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate By similarity.
Subcellular location	Mitochondrion membrane.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Membrane Mitochondrion
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial membrane Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›19	›19	2-oxoglutarate dehydrogenase E1 component		PRO_0000238928
Experimental info
	Non-terminal residue	19	1

Sequences

	Sequence		Length	Mass (Da)
	P81895-1 [UniParc]. Last modified June 1, 2000. Version 1. Checksum: 3AB2C6910C61EEF7	FASTA	19	2,024
	10 AQAAPVPRPV XLSKKTDSF

References

[1]

"Plant mitochondrial 2-oxoglutarate dehydrogenase complex: purification and characterization in potato." Millar A.H., Hill S.A., Leaver C.J. Biochem. J. 343:327-334(1999) [PubMed: 10510296] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION. Strain: cv. Romano. Tissue: Tuber.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ODO1_SOLTU

Accession

Primary (citable) accession number: P81895

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	June 1, 2000
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)