P81895 (ODO1_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: 2-oxoglutarate dehydrogenase, mitochondrial EC=1.2.4.2 Alternative name(s): 2-oxoglutarate dehydrogenase complex component E1 Short name=OGDC-E1 Alpha-ketoglutarate dehydrogenase
Organism	Solanum tuberosum (Potato) [Reference proteome]
Taxonomic identifier	4113 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length	19 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Ref.1
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. Ref.1
Cofactor	Thiamine pyrophosphate By similarity. UniProtKB P20967
Subcellular location	Mitochondrion membrane Ref.1.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Membrane Mitochondrion
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	generation of precursor metabolites and energy Inferred from direct assay Ref.1. Source: UniProtKB glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial membrane Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›19	›19	2-oxoglutarate dehydrogenase, mitochondrial		PRO_0000238928
Experimental info
	Non-terminal residue	19	1

Sequences

	Sequence		Length	Mass (Da)
	P81895 [UniParc]. Last modified June 1, 2000. Version 1. Checksum: 3AB2C6910C61EEF7	FASTA	19	2,024
	10 AQAAPVPRPV XLSKKTDSF

References

[1]

"Plant mitochondrial 2-oxoglutarate dehydrogenase complex: purification and characterization in potato." Millar A.H., Hill S.A., Leaver C.J. Biochem. J. 343:327-334(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION. Strain: cv. Romano. Tissue: Tuber.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ODO1_SOLTU

Accession

Primary (citable) accession number: P81895

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	June 1, 2000
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program