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P81877

- SSBP2_HUMAN

UniProt

P81877 - SSBP2_HUMAN

Protein

Single-stranded DNA-binding protein 2

Gene

SSBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. single-stranded DNA binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Single-stranded DNA-binding protein 2
    Alternative name(s):
    Sequence-specific single-stranded-DNA-binding protein 2
    Gene namesi
    Name:SSBP2
    Synonyms:SSDP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:15831. SSBP2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38046.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Single-stranded DNA-binding protein 2PRO_0000123826Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei6 – 61N6-acetyllysineBy similarity
    Modified residuei321 – 3211Phosphoserine1 Publication
    Modified residuei333 – 3331Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP81877.
    PaxDbiP81877.
    PRIDEiP81877.

    PTM databases

    PhosphoSiteiP81877.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiP81877.
    BgeeiP81877.
    CleanExiHS_SSBP2.
    GenevestigatoriP81877.

    Organism-specific databases

    HPAiCAB020834.

    Interactioni

    Protein-protein interaction databases

    BioGridi117164. 11 interactions.
    IntActiP81877. 11 interactions.
    MINTiMINT-1470493.
    STRINGi9606.ENSP00000322977.

    Structurei

    3D structure databases

    ProteinModelPortaliP81877.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 5033LisHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi100 – 293194Pro-richAdd
    BLAST
    Compositional biasi147 – 312166Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245801.
    HOGENOMiHOG000037785.
    HOVERGENiHBG068487.
    OMAiWQPNASA.
    OrthoDBiEOG7V4B0F.
    PhylomeDBiP81877.
    TreeFamiTF318961.

    Family and domain databases

    InterProiIPR006594. LisH_dimerisation.
    IPR008116. SSDP_DNA-bd.
    [Graphical view]
    PRINTSiPR01743. SSDNABINDING.
    SMARTiSM00667. LisH. 1 hit.
    [Graphical view]
    PROSITEiPS50896. LISH. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P81877-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK    50
    NITLGEPPGF LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP 100
    SPVLGNIPPG DGMPVGPVPP GFFQPFMSPR YPGGPRPPLR IPNQALGGVP 150
    GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL 200
    NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP 250
    GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM 300
    ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS 350
    ESYSPSMTMS V 361
    Length:361
    Mass (Da):37,828
    Last modified:January 10, 2003 - v2
    Checksum:iEC6F9B08EBFF673A
    GO
    Isoform 2 (identifier: P81877-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-124: Missing.
         320-352: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:298
    Mass (Da):31,479
    Checksum:iF04068F9E932A4EC
    GO
    Isoform 3 (identifier: P81877-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-143: Missing.

    Show »
    Length:341
    Mass (Da):35,568
    Checksum:i8EEFA5397A1A73EE
    GO
    Isoform 4 (identifier: P81877-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-124: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:331
    Mass (Da):35,000
    Checksum:i3496A6875143F773
    GO
    Isoform 5 (identifier: P81877-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-124: Missing.
         189-189: P → PQSDPWLSL

    Note: No experimental confirmation available.

    Show »
    Length:339
    Mass (Da):35,927
    Checksum:i92CE7812DF6F65D8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231A → V in CR936787. (PubMed:17974005)Curated
    Sequence conflicti158 – 1581S → R in CAB45699. (PubMed:11230166)Curated
    Sequence conflicti178 – 18912MTPPR…VPLGP → NDSSKRNGCLRTTVLTPGLS L in AAD27781. (PubMed:10931946)CuratedAdd
    BLAST
    Sequence conflicti255 – 2551M → V in BAH11905. (PubMed:14702039)Curated
    Sequence conflicti306 – 3061N → D in BAC11046. (PubMed:14702039)Curated
    Sequence conflicti346 – 3461N → S in BAH13151. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei95 – 12430Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_044744Add
    BLAST
    Alternative sequencei124 – 14320Missing in isoform 3. 1 PublicationVSP_045117Add
    BLAST
    Alternative sequencei189 – 1891P → PQSDPWLSL in isoform 5. 1 PublicationVSP_045580
    Alternative sequencei320 – 35233Missing in isoform 2. 1 PublicationVSP_044745Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY026275
    , AY026259, AY026260, AY026261, AY026262, AY026263, AY026264, AY026265, AY026266, AY026267, AY026268, AY026269, AY026270, AY026271, AY026272, AY026273, AY026274 Genomic DNA. Translation: AAK15803.1.
    AF077048 mRNA. Translation: AAD27781.1.
    AL080076 mRNA. Translation: CAB45699.1.
    AK074537 mRNA. Translation: BAC11046.1.
    AK293544 mRNA. Translation: BAH11528.1.
    AK294864 mRNA. Translation: BAH11905.1.
    AK299858 mRNA. Translation: BAH13151.1.
    AK312337 mRNA. Translation: BAG35258.1.
    CR936787 mRNA. No translation available.
    AC010623 Genomic DNA. No translation available.
    AC016562 Genomic DNA. No translation available.
    AC026419 Genomic DNA. No translation available.
    AC093250 Genomic DNA. No translation available.
    CH471084 Genomic DNA. Translation: EAW95879.1.
    BC017020 mRNA. Translation: AAH17020.1.
    CCDSiCCDS4056.1. [P81877-1]
    CCDS58960.1. [P81877-2]
    CCDS58961.1. [P81877-4]
    CCDS58962.1. [P81877-5]
    CCDS58963.1. [P81877-3]
    PIRiT12470.
    RefSeqiNP_001243661.1. NM_001256732.1.
    NP_001243662.1. NM_001256733.1. [P81877-3]
    NP_001243663.1. NM_001256734.1. [P81877-5]
    NP_001243664.1. NM_001256735.1. [P81877-4]
    NP_001243665.1. NM_001256736.1. [P81877-2]
    NP_036578.2. NM_012446.3. [P81877-1]
    UniGeneiHs.102735.

    Genome annotation databases

    EnsembliENST00000320672; ENSP00000322977; ENSG00000145687. [P81877-1]
    ENST00000505980; ENSP00000423969; ENSG00000145687. [P81877-3]
    ENST00000509053; ENSP00000422961; ENSG00000145687. [P81877-2]
    ENST00000514493; ENSP00000426183; ENSG00000145687. [P81877-4]
    ENST00000515395; ENSP00000424657; ENSG00000145687. [P81877-5]
    GeneIDi23635.
    KEGGihsa:23635.
    UCSCiuc003kho.4. human. [P81877-1]
    uc011ctp.3. human.

    Polymorphism databases

    DMDMi27734570.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY026275
    , AY026259 , AY026260 , AY026261 , AY026262 , AY026263 , AY026264 , AY026265 , AY026266 , AY026267 , AY026268 , AY026269 , AY026270 , AY026271 , AY026272 , AY026273 , AY026274 Genomic DNA. Translation: AAK15803.1 .
    AF077048 mRNA. Translation: AAD27781.1 .
    AL080076 mRNA. Translation: CAB45699.1 .
    AK074537 mRNA. Translation: BAC11046.1 .
    AK293544 mRNA. Translation: BAH11528.1 .
    AK294864 mRNA. Translation: BAH11905.1 .
    AK299858 mRNA. Translation: BAH13151.1 .
    AK312337 mRNA. Translation: BAG35258.1 .
    CR936787 mRNA. No translation available.
    AC010623 Genomic DNA. No translation available.
    AC016562 Genomic DNA. No translation available.
    AC026419 Genomic DNA. No translation available.
    AC093250 Genomic DNA. No translation available.
    CH471084 Genomic DNA. Translation: EAW95879.1 .
    BC017020 mRNA. Translation: AAH17020.1 .
    CCDSi CCDS4056.1. [P81877-1 ]
    CCDS58960.1. [P81877-2 ]
    CCDS58961.1. [P81877-4 ]
    CCDS58962.1. [P81877-5 ]
    CCDS58963.1. [P81877-3 ]
    PIRi T12470.
    RefSeqi NP_001243661.1. NM_001256732.1.
    NP_001243662.1. NM_001256733.1. [P81877-3 ]
    NP_001243663.1. NM_001256734.1. [P81877-5 ]
    NP_001243664.1. NM_001256735.1. [P81877-4 ]
    NP_001243665.1. NM_001256736.1. [P81877-2 ]
    NP_036578.2. NM_012446.3. [P81877-1 ]
    UniGenei Hs.102735.

    3D structure databases

    ProteinModelPortali P81877.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117164. 11 interactions.
    IntActi P81877. 11 interactions.
    MINTi MINT-1470493.
    STRINGi 9606.ENSP00000322977.

    PTM databases

    PhosphoSitei P81877.

    Polymorphism databases

    DMDMi 27734570.

    Proteomic databases

    MaxQBi P81877.
    PaxDbi P81877.
    PRIDEi P81877.

    Protocols and materials databases

    DNASUi 23635.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320672 ; ENSP00000322977 ; ENSG00000145687 . [P81877-1 ]
    ENST00000505980 ; ENSP00000423969 ; ENSG00000145687 . [P81877-3 ]
    ENST00000509053 ; ENSP00000422961 ; ENSG00000145687 . [P81877-2 ]
    ENST00000514493 ; ENSP00000426183 ; ENSG00000145687 . [P81877-4 ]
    ENST00000515395 ; ENSP00000424657 ; ENSG00000145687 . [P81877-5 ]
    GeneIDi 23635.
    KEGGi hsa:23635.
    UCSCi uc003kho.4. human. [P81877-1 ]
    uc011ctp.3. human.

    Organism-specific databases

    CTDi 23635.
    GeneCardsi GC05M080751.
    HGNCi HGNC:15831. SSBP2.
    HPAi CAB020834.
    MIMi 607389. gene.
    neXtProti NX_P81877.
    PharmGKBi PA38046.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245801.
    HOGENOMi HOG000037785.
    HOVERGENi HBG068487.
    OMAi WQPNASA.
    OrthoDBi EOG7V4B0F.
    PhylomeDBi P81877.
    TreeFami TF318961.

    Miscellaneous databases

    GeneWikii SSBP2.
    GenomeRNAii 23635.
    NextBioi 46415.
    PROi P81877.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P81877.
    Bgeei P81877.
    CleanExi HS_SSBP2.
    Genevestigatori P81877.

    Family and domain databases

    InterProi IPR006594. LisH_dimerisation.
    IPR008116. SSDP_DNA-bd.
    [Graphical view ]
    PRINTSi PR01743. SSDNABINDING.
    SMARTi SM00667. LisH. 1 hit.
    [Graphical view ]
    PROSITEi PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity."
      Castro P.D., Liang H., Liang J.C., Nagarajan L.
      Genomics 80:78-85(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
      Tissue: Brain, Cerebellum and Embryo.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Cerebellum.
    6. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND THR-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSSBP2_HUMAN
    AccessioniPrimary (citable) accession number: P81877
    Secondary accession number(s): B2R5W1
    , B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, Q8N2Q2, Q9BWW6, Q9Y4T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3