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P81877 (SSBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Single-stranded DNA-binding protein 2
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein 2
Gene names
Name:SSBP2
Synonyms:SSDP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Tissue specificity

Ubiquitous. Ref.1

Sequence similarities

Contains 1 LisH domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay. Source: LIFEdb

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsingle-stranded DNA binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P81877-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P81877-2)

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     320-352: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: P81877-3)

The sequence of this isoform differs from the canonical sequence as follows:
     124-143: Missing.
Isoform 4 (identifier: P81877-4)

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: P81877-5)

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     189-189: P → PQSDPWLSL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Single-stranded DNA-binding protein 2
PRO_0000123826

Regions

Domain18 – 5033LisH
Compositional bias100 – 293194Pro-rich
Compositional bias147 – 312166Gly-rich

Amino acid modifications

Modified residue61N6-acetyllysine By similarity
Modified residue3211Phosphoserine Ref.9
Modified residue3331Phosphothreonine Ref.9

Natural variations

Alternative sequence95 – 12430Missing in isoform 2, isoform 4 and isoform 5.
VSP_044744
Alternative sequence124 – 14320Missing in isoform 3.
VSP_045117
Alternative sequence1891P → PQSDPWLSL in isoform 5.
VSP_045580
Alternative sequence320 – 35233Missing in isoform 2.
VSP_044745

Experimental info

Sequence conflict231A → V in CR936787. Ref.5
Sequence conflict1581S → R in CAB45699. Ref.3
Sequence conflict178 – 18912MTPPR…VPLGP → NDSSKRNGCLRTTVLTPGLS L in AAD27781. Ref.2
Sequence conflict2551M → V in BAH11905. Ref.4
Sequence conflict3061N → D in BAC11046. Ref.4
Sequence conflict3461N → S in BAH13151. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: EC6F9B08EBFF673A

FASTA36137,828
        10         20         30         40         50         60 
MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF 

        70         80         90        100        110        120 
LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP SPVLGNIPPG DGMPVGPVPP 

       130        140        150        160        170        180 
GFFQPFMSPR YPGGPRPPLR IPNQALGGVP GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP 

       190        200        210        220        230        240 
PRGMVPLGPQ NYGGAMRPPL NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY 

       250        260        270        280        290        300 
VGPPGGGGPP GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM 

       310        320        330        340        350        360 
ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS ESYSPSMTMS 


V 

« Hide

Isoform 2 [UniParc].

Checksum: F04068F9E932A4EC
Show »

FASTA29831,479
Isoform 3 [UniParc].

Checksum: 8EEFA5397A1A73EE
Show »

FASTA34135,568
Isoform 4 [UniParc].

Checksum: 3496A6875143F773
Show »

FASTA33135,000
Isoform 5 [UniParc].

Checksum: 92CE7812DF6F65D8
Show »

FASTA33935,927

References

« Hide 'large scale' references
[1]"A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity."
Castro P.D., Liang H., Liang J.C., Nagarajan L.
Genomics 80:78-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Pituitary.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
Tissue: Brain, Cerebellum and Embryo.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Cerebellum.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND THR-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY026275 expand/collapse EMBL AC list , AY026259, AY026260, AY026261, AY026262, AY026263, AY026264, AY026265, AY026266, AY026267, AY026268, AY026269, AY026270, AY026271, AY026272, AY026273, AY026274 Genomic DNA. Translation: AAK15803.1.
AF077048 mRNA. Translation: AAD27781.1.
AL080076 mRNA. Translation: CAB45699.1.
AK074537 mRNA. Translation: BAC11046.1.
AK293544 mRNA. Translation: BAH11528.1.
AK294864 mRNA. Translation: BAH11905.1.
AK299858 mRNA. Translation: BAH13151.1.
AK312337 mRNA. Translation: BAG35258.1.
CR936787 mRNA. No translation available.
AC010623 Genomic DNA. No translation available.
AC016562 Genomic DNA. No translation available.
AC026419 Genomic DNA. No translation available.
AC093250 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95879.1.
BC017020 mRNA. Translation: AAH17020.1.
PIRT12470.
RefSeqNP_001243661.1. NM_001256732.1.
NP_001243662.1. NM_001256733.1.
NP_001243663.1. NM_001256734.1.
NP_001243664.1. NM_001256735.1.
NP_001243665.1. NM_001256736.1.
NP_036578.2. NM_012446.3.
UniGeneHs.102735.

3D structure databases

ProteinModelPortalP81877.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117164. 10 interactions.
IntActP81877. 11 interactions.
MINTMINT-1470493.
STRING9606.ENSP00000322977.

PTM databases

PhosphoSiteP81877.

Polymorphism databases

DMDM27734570.

Proteomic databases

PaxDbP81877.
PRIDEP81877.

Protocols and materials databases

DNASU23635.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320672; ENSP00000322977; ENSG00000145687. [P81877-1]
ENST00000505980; ENSP00000423969; ENSG00000145687. [P81877-3]
ENST00000509053; ENSP00000422961; ENSG00000145687. [P81877-2]
ENST00000514493; ENSP00000426183; ENSG00000145687. [P81877-4]
ENST00000515395; ENSP00000424657; ENSG00000145687. [P81877-5]
GeneID23635.
KEGGhsa:23635.
UCSCuc003kho.4. human. [P81877-1]
uc011ctp.3. human.

Organism-specific databases

CTD23635.
GeneCardsGC05M080751.
HGNCHGNC:15831. SSBP2.
HPACAB020834.
MIM607389. gene.
neXtProtNX_P81877.
PharmGKBPA38046.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245801.
HOGENOMHOG000037785.
HOVERGENHBG068487.
OMAWQPNASA.
OrthoDBEOG7V4B0F.
PhylomeDBP81877.
TreeFamTF318961.

Gene expression databases

ArrayExpressP81877.
BgeeP81877.
CleanExHS_SSBP2.
GenevestigatorP81877.

Family and domain databases

InterProIPR006594. LisH_dimerisation.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSPR01743. SSDNABINDING.
SMARTSM00667. LisH. 1 hit.
[Graphical view]
PROSITEPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSSBP2.
GenomeRNAi23635.
NextBio46415.
PROP81877.
SOURCESearch...

Entry information

Entry nameSSBP2_HUMAN
AccessionPrimary (citable) accession number: P81877
Secondary accession number(s): B2R5W1 expand/collapse secondary AC list , B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, Q8N2Q2, Q9BWW6, Q9Y4T7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: March 19, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM