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Protein

Single-stranded DNA-binding protein 2

Gene

SSBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 2
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein 2
Gene namesi
Name:SSBP2
Synonyms:SSDP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:15831. SSBP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23635.
OpenTargetsiENSG00000145687.
PharmGKBiPA38046.

Polymorphism and mutation databases

BioMutaiSSBP2.
DMDMi27734570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238261 – 361Single-stranded DNA-binding protein 2Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei130Asymmetric dimethylarginineBy similarity1
Modified residuei136Asymmetric dimethylarginineBy similarity1
Modified residuei140Asymmetric dimethylarginineBy similarity1
Modified residuei321PhosphoserineCombined sources1
Modified residuei326PhosphoserineBy similarity1
Modified residuei328PhosphoserineBy similarity1
Modified residuei333PhosphothreonineCombined sources1
Modified residuei354PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP81877.
MaxQBiP81877.
PaxDbiP81877.
PeptideAtlasiP81877.
PRIDEiP81877.

PTM databases

iPTMnetiP81877.
PhosphoSitePlusiP81877.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000145687.
CleanExiHS_SSBP2.
ExpressionAtlasiP81877. baseline and differential.
GenevisibleiP81877. HS.

Organism-specific databases

HPAiCAB020834.

Interactioni

Protein-protein interaction databases

BioGridi117164. 24 interactors.
DIPiDIP-29459N.
IntActiP81877. 13 interactors.
MINTiMINT-1470493.
STRINGi9606.ENSP00000322977.

Structurei

3D structure databases

ProteinModelPortaliP81877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 50LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 293Pro-richAdd BLAST194
Compositional biasi147 – 312Gly-richAdd BLAST166

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiP81877.
PhylomeDBiP81877.
TreeFamiTF318961.

Family and domain databases

InterProiIPR006594. LisH.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P81877-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK
60 70 80 90 100
NITLGEPPGF LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP
110 120 130 140 150
SPVLGNIPPG DGMPVGPVPP GFFQPFMSPR YPGGPRPPLR IPNQALGGVP
160 170 180 190 200
GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL
210 220 230 240 250
NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP
260 270 280 290 300
GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM
310 320 330 340 350
ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS
360
ESYSPSMTMS V
Length:361
Mass (Da):37,828
Last modified:January 10, 2003 - v2
Checksum:iEC6F9B08EBFF673A
GO
Isoform 2 (identifier: P81877-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     320-352: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):31,479
Checksum:iF04068F9E932A4EC
GO
Isoform 3 (identifier: P81877-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-143: Missing.

Show »
Length:341
Mass (Da):35,568
Checksum:i8EEFA5397A1A73EE
GO
Isoform 4 (identifier: P81877-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):35,000
Checksum:i3496A6875143F773
GO
Isoform 5 (identifier: P81877-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     189-189: P → PQSDPWLSL

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):35,927
Checksum:i92CE7812DF6F65D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → V in CR936787 (PubMed:17974005).Curated1
Sequence conflicti158S → R in CAB45699 (PubMed:11230166).Curated1
Sequence conflicti178 – 189MTPPR…VPLGP → NDSSKRNGCLRTTVLTPGLS L in AAD27781 (PubMed:10931946).CuratedAdd BLAST12
Sequence conflicti255M → V in BAH11905 (PubMed:14702039).Curated1
Sequence conflicti306N → D in BAC11046 (PubMed:14702039).Curated1
Sequence conflicti346N → S in BAH13151 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04474495 – 124Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_045117124 – 143Missing in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_045580189P → PQSDPWLSL in isoform 5. 1 Publication1
Alternative sequenceiVSP_044745320 – 352Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026275
, AY026259, AY026260, AY026261, AY026262, AY026263, AY026264, AY026265, AY026266, AY026267, AY026268, AY026269, AY026270, AY026271, AY026272, AY026273, AY026274 Genomic DNA. Translation: AAK15803.1.
AF077048 mRNA. Translation: AAD27781.1.
AL080076 mRNA. Translation: CAB45699.1.
AK074537 mRNA. Translation: BAC11046.1.
AK293544 mRNA. Translation: BAH11528.1.
AK294864 mRNA. Translation: BAH11905.1.
AK299858 mRNA. Translation: BAH13151.1.
AK312337 mRNA. Translation: BAG35258.1.
CR936787 mRNA. No translation available.
AC010623 Genomic DNA. No translation available.
AC016562 Genomic DNA. No translation available.
AC026419 Genomic DNA. No translation available.
AC093250 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95879.1.
BC017020 mRNA. Translation: AAH17020.1.
CCDSiCCDS4056.1. [P81877-1]
CCDS58960.1. [P81877-2]
CCDS58961.1. [P81877-4]
CCDS58962.1. [P81877-5]
CCDS58963.1. [P81877-3]
PIRiT12470.
RefSeqiNP_001243662.1. NM_001256733.2. [P81877-3]
NP_001243663.1. NM_001256734.2. [P81877-5]
NP_001243664.1. NM_001256735.2. [P81877-4]
NP_001243665.1. NM_001256736.2. [P81877-2]
NP_036578.2. NM_012446.4. [P81877-1]
UniGeneiHs.102735.

Genome annotation databases

EnsembliENST00000320672; ENSP00000322977; ENSG00000145687. [P81877-1]
ENST00000505980; ENSP00000423969; ENSG00000145687. [P81877-3]
ENST00000509053; ENSP00000422961; ENSG00000145687. [P81877-2]
ENST00000514493; ENSP00000426183; ENSG00000145687. [P81877-4]
ENST00000515395; ENSP00000424657; ENSG00000145687. [P81877-5]
GeneIDi23635.
KEGGihsa:23635.
UCSCiuc003kho.5. human. [P81877-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026275
, AY026259, AY026260, AY026261, AY026262, AY026263, AY026264, AY026265, AY026266, AY026267, AY026268, AY026269, AY026270, AY026271, AY026272, AY026273, AY026274 Genomic DNA. Translation: AAK15803.1.
AF077048 mRNA. Translation: AAD27781.1.
AL080076 mRNA. Translation: CAB45699.1.
AK074537 mRNA. Translation: BAC11046.1.
AK293544 mRNA. Translation: BAH11528.1.
AK294864 mRNA. Translation: BAH11905.1.
AK299858 mRNA. Translation: BAH13151.1.
AK312337 mRNA. Translation: BAG35258.1.
CR936787 mRNA. No translation available.
AC010623 Genomic DNA. No translation available.
AC016562 Genomic DNA. No translation available.
AC026419 Genomic DNA. No translation available.
AC093250 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95879.1.
BC017020 mRNA. Translation: AAH17020.1.
CCDSiCCDS4056.1. [P81877-1]
CCDS58960.1. [P81877-2]
CCDS58961.1. [P81877-4]
CCDS58962.1. [P81877-5]
CCDS58963.1. [P81877-3]
PIRiT12470.
RefSeqiNP_001243662.1. NM_001256733.2. [P81877-3]
NP_001243663.1. NM_001256734.2. [P81877-5]
NP_001243664.1. NM_001256735.2. [P81877-4]
NP_001243665.1. NM_001256736.2. [P81877-2]
NP_036578.2. NM_012446.4. [P81877-1]
UniGeneiHs.102735.

3D structure databases

ProteinModelPortaliP81877.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117164. 24 interactors.
DIPiDIP-29459N.
IntActiP81877. 13 interactors.
MINTiMINT-1470493.
STRINGi9606.ENSP00000322977.

PTM databases

iPTMnetiP81877.
PhosphoSitePlusiP81877.

Polymorphism and mutation databases

BioMutaiSSBP2.
DMDMi27734570.

Proteomic databases

EPDiP81877.
MaxQBiP81877.
PaxDbiP81877.
PeptideAtlasiP81877.
PRIDEiP81877.

Protocols and materials databases

DNASUi23635.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320672; ENSP00000322977; ENSG00000145687. [P81877-1]
ENST00000505980; ENSP00000423969; ENSG00000145687. [P81877-3]
ENST00000509053; ENSP00000422961; ENSG00000145687. [P81877-2]
ENST00000514493; ENSP00000426183; ENSG00000145687. [P81877-4]
ENST00000515395; ENSP00000424657; ENSG00000145687. [P81877-5]
GeneIDi23635.
KEGGihsa:23635.
UCSCiuc003kho.5. human. [P81877-1]

Organism-specific databases

CTDi23635.
DisGeNETi23635.
GeneCardsiSSBP2.
HGNCiHGNC:15831. SSBP2.
HPAiCAB020834.
MIMi607389. gene.
neXtProtiNX_P81877.
OpenTargetsiENSG00000145687.
PharmGKBiPA38046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiP81877.
PhylomeDBiP81877.
TreeFamiTF318961.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145687-MONOMER.

Miscellaneous databases

ChiTaRSiSSBP2. human.
GeneWikiiSSBP2.
GenomeRNAii23635.
PROiP81877.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145687.
CleanExiHS_SSBP2.
ExpressionAtlasiP81877. baseline and differential.
GenevisibleiP81877. HS.

Family and domain databases

InterProiIPR006594. LisH.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP2_HUMAN
AccessioniPrimary (citable) accession number: P81877
Secondary accession number(s): B2R5W1
, B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, Q8N2Q2, Q9BWW6, Q9Y4T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.