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P81877

- SSBP2_HUMAN

UniProt

P81877 - SSBP2_HUMAN

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Protein

Single-stranded DNA-binding protein 2

Gene

SSBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 2
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein 2
Gene namesi
Name:SSBP2
Synonyms:SSDP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:15831. SSBP2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Single-stranded DNA-binding protein 2PRO_0000123826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61N6-acetyllysineBy similarity
Modified residuei321 – 3211Phosphoserine1 Publication
Modified residuei333 – 3331Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP81877.
PaxDbiP81877.
PRIDEiP81877.

PTM databases

PhosphoSiteiP81877.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiP81877.
CleanExiHS_SSBP2.
ExpressionAtlasiP81877. baseline and differential.
GenevestigatoriP81877.

Organism-specific databases

HPAiCAB020834.

Interactioni

Protein-protein interaction databases

BioGridi117164. 22 interactions.
IntActiP81877. 11 interactions.
MINTiMINT-1470493.
STRINGi9606.ENSP00000322977.

Structurei

3D structure databases

ProteinModelPortaliP81877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5033LisHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 293194Pro-richAdd
BLAST
Compositional biasi147 – 312166Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG245801.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiP81877.
OMAiWQPNASA.
OrthoDBiEOG7V4B0F.
PhylomeDBiP81877.
TreeFamiTF318961.

Family and domain databases

InterProiIPR006594. LisH_dimerisation.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P81877-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK
60 70 80 90 100
NITLGEPPGF LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP
110 120 130 140 150
SPVLGNIPPG DGMPVGPVPP GFFQPFMSPR YPGGPRPPLR IPNQALGGVP
160 170 180 190 200
GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL
210 220 230 240 250
NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP
260 270 280 290 300
GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM
310 320 330 340 350
ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS
360
ESYSPSMTMS V
Length:361
Mass (Da):37,828
Last modified:January 10, 2003 - v2
Checksum:iEC6F9B08EBFF673A
GO
Isoform 2 (identifier: P81877-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     320-352: Missing.

Note: No experimental confirmation available.

Show »
Length:298
Mass (Da):31,479
Checksum:iF04068F9E932A4EC
GO
Isoform 3 (identifier: P81877-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-143: Missing.

Show »
Length:341
Mass (Da):35,568
Checksum:i8EEFA5397A1A73EE
GO
Isoform 4 (identifier: P81877-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.

Note: No experimental confirmation available.

Show »
Length:331
Mass (Da):35,000
Checksum:i3496A6875143F773
GO
Isoform 5 (identifier: P81877-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     189-189: P → PQSDPWLSL

Note: No experimental confirmation available.

Show »
Length:339
Mass (Da):35,927
Checksum:i92CE7812DF6F65D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231A → V in CR936787. (PubMed:17974005)Curated
Sequence conflicti158 – 1581S → R in CAB45699. (PubMed:11230166)Curated
Sequence conflicti178 – 18912MTPPR…VPLGP → NDSSKRNGCLRTTVLTPGLS L in AAD27781. (PubMed:10931946)CuratedAdd
BLAST
Sequence conflicti255 – 2551M → V in BAH11905. (PubMed:14702039)Curated
Sequence conflicti306 – 3061N → D in BAC11046. (PubMed:14702039)Curated
Sequence conflicti346 – 3461N → S in BAH13151. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 12430Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_044744Add
BLAST
Alternative sequencei124 – 14320Missing in isoform 3. 1 PublicationVSP_045117Add
BLAST
Alternative sequencei189 – 1891P → PQSDPWLSL in isoform 5. 1 PublicationVSP_045580
Alternative sequencei320 – 35233Missing in isoform 2. 1 PublicationVSP_044745Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026275
, AY026259, AY026260, AY026261, AY026262, AY026263, AY026264, AY026265, AY026266, AY026267, AY026268, AY026269, AY026270, AY026271, AY026272, AY026273, AY026274 Genomic DNA. Translation: AAK15803.1.
AF077048 mRNA. Translation: AAD27781.1.
AL080076 mRNA. Translation: CAB45699.1.
AK074537 mRNA. Translation: BAC11046.1.
AK293544 mRNA. Translation: BAH11528.1.
AK294864 mRNA. Translation: BAH11905.1.
AK299858 mRNA. Translation: BAH13151.1.
AK312337 mRNA. Translation: BAG35258.1.
CR936787 mRNA. No translation available.
AC010623 Genomic DNA. No translation available.
AC016562 Genomic DNA. No translation available.
AC026419 Genomic DNA. No translation available.
AC093250 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95879.1.
BC017020 mRNA. Translation: AAH17020.1.
CCDSiCCDS4056.1. [P81877-1]
CCDS58960.1. [P81877-2]
CCDS58961.1. [P81877-4]
CCDS58962.1. [P81877-5]
CCDS58963.1. [P81877-3]
PIRiT12470.
RefSeqiNP_001243661.1. NM_001256732.1.
NP_001243662.1. NM_001256733.1. [P81877-3]
NP_001243663.1. NM_001256734.1. [P81877-5]
NP_001243664.1. NM_001256735.1. [P81877-4]
NP_001243665.1. NM_001256736.1. [P81877-2]
NP_036578.2. NM_012446.3. [P81877-1]
UniGeneiHs.102735.

Genome annotation databases

EnsembliENST00000320672; ENSP00000322977; ENSG00000145687. [P81877-1]
ENST00000505980; ENSP00000423969; ENSG00000145687. [P81877-3]
ENST00000509053; ENSP00000422961; ENSG00000145687. [P81877-2]
ENST00000514493; ENSP00000426183; ENSG00000145687. [P81877-4]
ENST00000515395; ENSP00000424657; ENSG00000145687. [P81877-5]
GeneIDi23635.
KEGGihsa:23635.
UCSCiuc003kho.4. human. [P81877-1]
uc011ctp.3. human.

Polymorphism databases

DMDMi27734570.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026275
, AY026259 , AY026260 , AY026261 , AY026262 , AY026263 , AY026264 , AY026265 , AY026266 , AY026267 , AY026268 , AY026269 , AY026270 , AY026271 , AY026272 , AY026273 , AY026274 Genomic DNA. Translation: AAK15803.1 .
AF077048 mRNA. Translation: AAD27781.1 .
AL080076 mRNA. Translation: CAB45699.1 .
AK074537 mRNA. Translation: BAC11046.1 .
AK293544 mRNA. Translation: BAH11528.1 .
AK294864 mRNA. Translation: BAH11905.1 .
AK299858 mRNA. Translation: BAH13151.1 .
AK312337 mRNA. Translation: BAG35258.1 .
CR936787 mRNA. No translation available.
AC010623 Genomic DNA. No translation available.
AC016562 Genomic DNA. No translation available.
AC026419 Genomic DNA. No translation available.
AC093250 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95879.1 .
BC017020 mRNA. Translation: AAH17020.1 .
CCDSi CCDS4056.1. [P81877-1 ]
CCDS58960.1. [P81877-2 ]
CCDS58961.1. [P81877-4 ]
CCDS58962.1. [P81877-5 ]
CCDS58963.1. [P81877-3 ]
PIRi T12470.
RefSeqi NP_001243661.1. NM_001256732.1.
NP_001243662.1. NM_001256733.1. [P81877-3 ]
NP_001243663.1. NM_001256734.1. [P81877-5 ]
NP_001243664.1. NM_001256735.1. [P81877-4 ]
NP_001243665.1. NM_001256736.1. [P81877-2 ]
NP_036578.2. NM_012446.3. [P81877-1 ]
UniGenei Hs.102735.

3D structure databases

ProteinModelPortali P81877.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117164. 22 interactions.
IntActi P81877. 11 interactions.
MINTi MINT-1470493.
STRINGi 9606.ENSP00000322977.

PTM databases

PhosphoSitei P81877.

Polymorphism databases

DMDMi 27734570.

Proteomic databases

MaxQBi P81877.
PaxDbi P81877.
PRIDEi P81877.

Protocols and materials databases

DNASUi 23635.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320672 ; ENSP00000322977 ; ENSG00000145687 . [P81877-1 ]
ENST00000505980 ; ENSP00000423969 ; ENSG00000145687 . [P81877-3 ]
ENST00000509053 ; ENSP00000422961 ; ENSG00000145687 . [P81877-2 ]
ENST00000514493 ; ENSP00000426183 ; ENSG00000145687 . [P81877-4 ]
ENST00000515395 ; ENSP00000424657 ; ENSG00000145687 . [P81877-5 ]
GeneIDi 23635.
KEGGi hsa:23635.
UCSCi uc003kho.4. human. [P81877-1 ]
uc011ctp.3. human.

Organism-specific databases

CTDi 23635.
GeneCardsi GC05M080751.
HGNCi HGNC:15831. SSBP2.
HPAi CAB020834.
MIMi 607389. gene.
neXtProti NX_P81877.
PharmGKBi PA38046.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245801.
GeneTreei ENSGT00390000009187.
HOGENOMi HOG000037785.
HOVERGENi HBG068487.
InParanoidi P81877.
OMAi WQPNASA.
OrthoDBi EOG7V4B0F.
PhylomeDBi P81877.
TreeFami TF318961.

Miscellaneous databases

ChiTaRSi SSBP2. human.
GeneWikii SSBP2.
GenomeRNAii 23635.
NextBioi 46415.
PROi P81877.
SOURCEi Search...

Gene expression databases

Bgeei P81877.
CleanExi HS_SSBP2.
ExpressionAtlasi P81877. baseline and differential.
Genevestigatori P81877.

Family and domain databases

InterProi IPR006594. LisH_dimerisation.
IPR008116. SSDP_DNA-bd.
[Graphical view ]
PRINTSi PR01743. SSDNABINDING.
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity."
    Castro P.D., Liang H., Liang J.C., Nagarajan L.
    Genomics 80:78-85(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pituitary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
    Tissue: Brain, Cerebellum and Embryo.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Cerebellum.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND THR-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSBP2_HUMAN
AccessioniPrimary (citable) accession number: P81877
Secondary accession number(s): B2R5W1
, B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, Q8N2Q2, Q9BWW6, Q9Y4T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3