P81877 (SSBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Single-stranded DNA-binding protein 2

Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein 2

Gene names

Name:	SSBP2
Synonyms:	SSDP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Tissue specificity	Ubiquitous. Ref.1
Sequence similarities	Contains 1 LisH domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay. Source: LIFEdb nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	single-stranded DNA binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P81877-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P81877-2)

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     320-352: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P81877-3)

The sequence of this isoform differs from the canonical sequence as follows:
     124-143: Missing.

Isoform 4 (identifier: P81877-4)

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: P81877-5)

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.
     189-189: P → PQSDPWLSL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Single-stranded DNA-binding protein 2		PRO_0000123826
Regions
	Domain	18 – 50	33	LisH
	Compositional bias	100 – 293	194	Pro-rich
	Compositional bias	147 – 312	166	Gly-rich
Amino acid modifications
	Modified residue	321	1	Phosphoserine Ref.9
	Modified residue	333	1	Phosphothreonine Ref.9
Natural variations
	Alternative sequence	95 – 124	30	Missing in isoform 2, isoform 4 and isoform 5.		VSP_044744
	Alternative sequence	124 – 143	20	Missing in isoform 3.		VSP_045117
	Alternative sequence	189	1	P → PQSDPWLSL in isoform 5.		VSP_045580
	Alternative sequence	320 – 352	33	Missing in isoform 2.		VSP_044745
Experimental info
	Sequence conflict	23	1	A → V in CR936787. Ref.5
	Sequence conflict	158	1	S → R in CAB45699. Ref.3
	Sequence conflict	178 – 189	12	MTPPR…VPLGP → NDSSKRNGCLRTTVLTPGLS L in AAD27781. Ref.2
	Sequence conflict	255	1	M → V in BAH11905. Ref.4
	Sequence conflict	306	1	N → D in BAC11046. Ref.4
	Sequence conflict	346	1	N → S in BAH13151. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2003. Version 2. Checksum: EC6F9B08EBFF673A	FASTA	361	37,828
	10 20 30 40 50 60 MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF 70 80 90 100 110 120 LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP SPVLGNIPPG DGMPVGPVPP 130 140 150 160 170 180 GFFQPFMSPR YPGGPRPPLR IPNQALGGVP GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP 190 200 210 220 230 240 PRGMVPLGPQ NYGGAMRPPL NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY 250 260 270 280 290 300 VGPPGGGGPP GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM 310 320 330 340 350 360 ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS ESYSPSMTMS V
	Isoform 2 [UniParc]. Checksum: F04068F9E932A4EC	FASTA	298	31,479
	10 20 30 40 50 60 MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF 70 80 90 100 110 120 LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYPFMSPR YPGGPRPPLR IPNQALGGVP 130 140 150 160 170 180 GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL NALGGPGMPG 190 200 210 220 230 240 MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP GTPIMPSPAD STNSGDNMYT 250 260 270 280 290 LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM ESHHMNGSLG SGDMDSISKY SPSMTMSV
	Isoform 3 [UniParc]. Checksum: 8EEFA5397A1A73EE	FASTA	341	35,568
	10 20 30 40 50 60 MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF 70 80 90 100 110 120 LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP SPVLGNIPPG DGMPVGPVPP 130 140 150 160 170 180 GFFQALGGVP GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL 190 200 210 220 230 240 NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP GTPIMPSPAD 250 260 270 280 290 300 STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM ESHHMNGSLG SGDMDSISKN 310 320 330 340 SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS ESYSPSMTMS V
	Isoform 4 [UniParc]. Checksum: 3496A6875143F773	FASTA	331	35,000
	10 20 30 40 50 60 MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF 70 80 90 100 110 120 LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYPFMSPR YPGGPRPPLR IPNQALGGVP 130 140 150 160 170 180 GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL NALGGPGMPG 190 200 210 220 230 240 MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP GTPIMPSPAD STNSGDNMYT 250 260 270 280 290 300 LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ 310 320 330 PGTPRDDGEM GGNFLNPFQS ESYSPSMTMS V
	Isoform 5 [UniParc]. Checksum: 92CE7812DF6F65D8	FASTA	339	35,927
	10 20 30 40 50 60 MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF 70 80 90 100 110 120 LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYPFMSPR YPGGPRPPLR IPNQALGGVP 130 140 150 160 170 180 GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ SDPWLSLQNY GGAMRPPLNA 190 200 210 220 230 240 LGGPGMPGMN MGPGGGRPWP NPTNANSIPY SSASPGNYVG PPGGGGPPGT PIMPSPADST 250 260 270 280 290 300 NSGDNMYTLM NAVPPGPNRP NFPMGPGSDG PMGGLGGMES HHMNGSLGSG DMDSISKNSP 310 320 330 NNMSLSNQPG TPRDDGEMGG NFLNPFQSES YSPSMTMSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity." Castro P.D., Liang H., Liang J.C., Nagarajan L. Genomics 80:78-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pituitary.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5). Tissue: Brain, Cerebellum and Embryo.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Cerebellum.
[6]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND THR-333, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026275 , AY026259, AY026260, AY026261, AY026262, AY026263, AY026264, AY026265, AY026266, AY026267, AY026268, AY026269, AY026270, AY026271, AY026272, AY026273, AY026274 Genomic DNA. Translation: AAK15803.1. AF077048 mRNA. Translation: AAD27781.1. AL080076 mRNA. Translation: CAB45699.1. AK074537 mRNA. Translation: BAC11046.1. AK293544 mRNA. Translation: BAH11528.1. AK294864 mRNA. Translation: BAH11905.1. AK299858 mRNA. Translation: BAH13151.1. AK312337 mRNA. Translation: BAG35258.1. CR936787 mRNA. No translation available. AC010623 Genomic DNA. No translation available. AC016562 Genomic DNA. No translation available. AC026419 Genomic DNA. No translation available. AC093250 Genomic DNA. No translation available. CH471084 Genomic DNA. Translation: EAW95879.1. BC017020 mRNA. Translation: AAH17020.1.
IPI	IPI00294052. IPI00922103. IPI00963832. IPI00966514.
PIR	T12470.
RefSeq	NP_001243661.1. NM_001256732.1. NP_001243662.1. NM_001256733.1. NP_001243663.1. NM_001256734.1. NP_001243664.1. NM_001256735.1. NP_001243665.1. NM_001256736.1. NP_036578.2. NM_012446.3.
UniGene	Hs.102735.
3D structure databases
ProteinModelPortal	P81877.
ModBase	Search...
Protein-protein interaction databases
IntAct	P81877. 10 interactions.
MINT	MINT-1470493.
STRING	9606.ENSP00000322977.
PTM databases
PhosphoSite	P81877.
Polymorphism databases
DMDM	27734570.
Proteomic databases
PaxDb	P81877.
PRIDE	P81877.
Protocols and materials databases
DNASU	23635.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320672; ENSP00000322977; ENSG00000145687. ENST00000505980; ENSP00000423969; ENSG00000145687. ENST00000509053; ENSP00000422961; ENSG00000145687. ENST00000514493; ENSP00000426183; ENSG00000145687. ENST00000515395; ENSP00000424657; ENSG00000145687.
GeneID	23635.
KEGG	hsa:23635.
UCSC	uc003khn.3. human.
Organism-specific databases
CTD	23635.
GeneCards	GC05M080751.
HGNC	HGNC:15831. SSBP2.
HPA	CAB020834.
MIM	607389. gene.
neXtProt	NX_P81877.
PharmGKB	PA38046.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245801.
HOGENOM	HOG000037785.
HOVERGEN	HBG068487.
OMA	WQPNASA.
OrthoDB	EOG469QW3.
PhylomeDB	P81877.
Gene expression databases
ArrayExpress	P81877.
Bgee	P81877.
CleanEx	HS_SSBP2.
Genevestigator	P81877.
GermOnline	ENSG00000145687. Homo sapiens.
Family and domain databases
InterPro	IPR006594. LisH_dimerisation. IPR008116. SSDP_DNA-bd. IPR007591. SSDP_ss-bd. [Graphical view]
PANTHER	PTHR12610. PTHR12610. 1 hit.
Pfam	PF04503. SSDP. 1 hit. [Graphical view]
PRINTS	PR01743. SSDNABINDING.
SMART	SM00667. LisH. 1 hit. [Graphical view]
PROSITE	PS50896. LISH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23635.
NextBio	46415.
SOURCE	Search...

Entry information

Entry name

SSBP2_HUMAN

Accession

Primary (citable) accession number: P81877
Secondary accession number(s): B2R5W1 , B7Z1J2, B7Z2L9, B7Z665, D6RH18, E9PB74, E9PDA8, Q8N2Q2, Q9BWW6, Q9Y4T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	January 10, 2003
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.