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Protein

Microneme antigen L2

Gene
N/A
Organism
Sarcocystis muris
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18Carbohydrate1
Binding sitei59Carbohydrate1
Binding sitei66Carbohydrate1
Binding sitei71Carbohydrate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Microneme antigen L2
Alternative name(s):
Lectin SML2
OrganismiSarcocystis muris
Taxonomic identifieri5813 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeSarcocystis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964791 – 138Microneme antigen L2Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 78
Disulfide bondi34 ↔ 56
Disulfide bondi38 ↔ 44
Disulfide bondi82 ↔ 86
Disulfide bondi107 ↔ 127
Disulfide bondi111 ↔ 117

Post-translational modificationi

Contains six disulfide bonds.

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Cyst merozoites.

Interactioni

Subunit structurei

Homodimer or heterodimer.1 Publication

Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 14Combined sources3
Beta strandi16 – 18Combined sources3
Beta strandi22 – 27Combined sources6
Helixi31 – 40Combined sources10
Beta strandi46 – 50Combined sources5
Turni51 – 53Combined sources3
Beta strandi55 – 59Combined sources5
Beta strandi65 – 67Combined sources3
Beta strandi71 – 76Combined sources6
Beta strandi84 – 87Combined sources4
Beta strandi94 – 98Combined sources5
Helixi105 – 112Combined sources8
Beta strandi119 – 121Combined sources3
Helixi123 – 125Combined sources3
Beta strandi126 – 130Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YILX-ray1.95A/B/C/D/E/F1-138[»]
2YIOX-ray2.43A/B1-138[»]
2YIPX-ray2.14A/B/C/D/E/F1-138[»]
SMRiP81860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81860.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 78PAN 1PROSITE-ProRule annotationAdd BLAST70
Domaini82 – 138PAN 2PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the microneme antigen family.Curated
Contains 2 PAN domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR000177. Apple.
IPR003609. Pan_app.
[Graphical view]
PfamiPF00024. PAN_1. 1 hit.
PF14295. PAN_4. 1 hit.
[Graphical view]
SMARTiSM00223. APPLE. 1 hit.
SM00473. PAN_AP. 1 hit.
[Graphical view]
PROSITEiPS50948. PAN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AGPQLDVSCF AHDKNIGSRT EQLSVVHVAS AQDCMKECQA LPTCSHFTYN
60 70 80 90 100
KNSKKCHLKA GAPEFYTYTG DMTGPRSCEH NCSDACWMDG NNPLAVWDYS
110 120 130
GQPPALCWAA CMGTPGCDLY TFQGMTCKLY SQTSSKRA
Length:138
Mass (Da):15,078
Last modified:May 30, 2000 - v1
Checksum:iB37D3010A5E52E6B
GO

Mass spectrometryi

Molecular mass is 15066 Da from positions 1 - 138. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130977 Genomic DNA. Translation: AAF36512.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130977 Genomic DNA. Translation: AAF36512.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YILX-ray1.95A/B/C/D/E/F1-138[»]
2YIOX-ray2.43A/B1-138[»]
2YIPX-ray2.14A/B/C/D/E/F1-138[»]
SMRiP81860.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP81860.

Family and domain databases

InterProiIPR000177. Apple.
IPR003609. Pan_app.
[Graphical view]
PfamiPF00024. PAN_1. 1 hit.
PF14295. PAN_4. 1 hit.
[Graphical view]
SMARTiSM00223. APPLE. 1 hit.
SM00473. PAN_AP. 1 hit.
[Graphical view]
PROSITEiPS50948. PAN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIA2_SARMU
AccessioniPrimary (citable) accession number: P81860
Secondary accession number(s): Q549G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.