P81827 (UP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Urinary protein 1 Short name=UP-1 Short name=rUP-1 Alternative name(s): Liver regeneration-related protein LRRG05
Organism	Rattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier	10116 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Post-translational modification	N-glycosylated Probable.
Sequence similarities	Contains 1 UPAR/Ly6 domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.1 Ref.3
	Chain	22 – 101	80	Urinary protein 1		PRO_0000036169
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Disulfide bond	24 ↔ 51		Potential
	Disulfide bond	27 ↔ 36		Potential
	Disulfide bond	43 ↔ 70		Potential
	Disulfide bond	73 ↔ 89		Potential
	Disulfide bond	90 ↔ 96		Potential

Sequences

	Sequence		Length	Mass (Da)
	P81827 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 03021BC9FFE75646	FASTA	101	10,960
	10 20 30 40 50 60 MGKPILLLPL GLSLLMSSLL ALQCFRCESL DSTGLCRVGR RICQTYPDEI CAWVVVTTRD 70 80 90 100 GKFVYGNQSC AECIGTTVEH GSLIISTNCC SATPFCNMVH P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The characterisation of novel secreted Ly-6 proteins from rat urine by the combined use of two-dimensional gel electrophoresis, microbore high performance liquid chromatography and expressed sequence tag data." Southan C., Cutler P., Birrell H., Connell J., Fantom K.G.M., Sims M., Shaikh N., Schneider K. Proteomics 2:187-196(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-47, IDENTIFICATION. Tissue: Urine.
[2]	"Liver regeneration after PH." Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	"Proteins of rat serum, urine, and cerebrospinal fluid: VI. Further protein identifications and interstrain comparison." Wait R., Gianazza E., Eberini I., Sironi L., Dunn M.J., Gemeiner M., Miller I. Electrophoresis 22:3043-3052(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-37 AND 42-62.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF198441 mRNA. Translation: AAF15598.1. AY327506 mRNA. Translation: AAP97738.1.
IPI	IPI00205273.
RefSeq	NP_001030122.2. NM_001034950.2.
UniGene	Rn.144564. Rn.224549.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000050106.
Proteomic databases
PRIDE	P81827.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000042860; ENSRNOP00000050106; ENSRNOG00000045799.
GeneID	619560.
KEGG	rno:619560.
UCSC	RGD:1561250. rat.
Organism-specific databases
CTD	619560.
Phylogenomic databases
GeneTree	ENSGT00700000105314.
HOGENOM	HOG000082505.
HOVERGEN	HBG017754.
InParanoid	P81827.
Gene expression databases
Genevestigator	P81827.
GermOnline	ENSRNOG00000028823. Rattus norvegicus.
Family and domain databases
ProtoNet	Search...
Other
NextBio	714650.

Entry information

Entry name

UP1_RAT

Accession

Primary (citable) accession number: P81827
Secondary accession number(s): Q53ZD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program