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P81781 (BLC6_VIBCL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase CARB-6

EC=3.5.2.6
Alternative name(s):
Carbenicillinase 6
Gene names
Name:carB6
Encoded onPlasmid
OrganismVibrio cholerae
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes both ticarcillin and oxacillin.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by clavulanic acid, sulbactam and tazobactam.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 288271Beta-lactamase CARB-6
PRO_0000017045

Regions

Region229 – 2313Substrate binding By similarity

Sites

Active site651Acyl-ester intermediate By similarity

Amino acid modifications

Disulfide bond72 ↔ 118 Potential

Sequences

Sequence LengthMass (Da)Tools
P81781 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: FBBE71A6AB090928

FASTA28831,430
        10         20         30         40         50         60 
MKFLLAFSLL IPSVVFASSS KFQQVEQDVK AIEVSLSARI GVSVLDTQNG EYWDYNGNQR 

        70         80         90        100        110        120 
FPLTSTFKTI ACAKLLYDAE QGKVNPNSTV EIKKADLVTY SPVIEKQVGQ AITLDDACFA 

       130        140        150        160        170        180 
TMTTSDNTAA NIILSAVGGP KGVTDFLRQI GDKETRLDRI EPDLNEGKLG DLRDTTTPKA 

       190        200        210        220        230        240 
IASTLNQLLF GSTLSEASQK KLESWMVNNQ VTGNLLRSVL PVKWSIADRS GAGGFGARSI 

       250        260        270        280 
TAIVWSEEKK TIIVSIYLAQ TEASMAERND AIVKIGRSIF EVYTSQSR 

« Hide

References

[1]"Characterization and nucleotide sequence of CARB-6, a new carbenicillin-hydrolyzing beta-lactamase from Vibrio cholerae."
Choury D., Aubert G., Szajnert M.-F., Azibi K., Delpech M., Paul G.
Antimicrob. Agents Chemother. 43:297-301(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: NON-O1 and NON-O139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030945 Genomic DNA. Translation: AAD19217.1.

3D structure databases

ProteinModelPortalP81781.
SMRP81781. Positions 20-285.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLC6_VIBCL
AccessionPrimary (citable) accession number: P81781
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families