P81764 (ADHR_DROPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase-related 31 kDa protein

Gene names

Name:	Adhr
Synonyms:	Adh-dup
ORF Names:	GA25223

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly)

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Alcohol dehydrogenase-related 31 kDa protein		PRO_0000054511
Regions
	Nucleotide binding	11 – 34	24	NAD or NADP By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Binding site	139	1	Substrate By similarity
Experimental info
	Sequence conflict	172	1	F → Y in CAA68646. Ref.1
	Sequence conflict	172	1	F → Y in AAL35977. Ref.2
	Sequence conflict	200	1	A → E in CAA68646. Ref.1
	Sequence conflict	200	1	A → E in AAL35977. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P81764 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: 5E689483773250EF	FASTA	278	30,821
	10 20 30 40 50 60 MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF 70 80 90 100 110 120 WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL 130 140 150 160 170 180 PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YFTQNGVAVM 190 200 210 220 230 240 AVCCGPTKVF VDRELTAFLA YGQSFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD 250 260 270 KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Adh gene region of Drosophila pseudoobscura: evolutionary change and evidence for an ancient gene duplication." Schaeffer S.W., Aquadro C.F. Genetics 117:61-73(1987) [PubMed: 3666441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular population genetics of sequence length diversity in the Adh region of Drosophila pseudoobscura." Schaeffer S.W. Genet. Res. 80:163-175(2002) [PubMed: 12688655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PS271.
[3]	"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y00602 Genomic DNA. Translation: CAA68646.1. U64535 Genomic DNA. Translation: AAL35977.1. CH379058 Genomic DNA. Translation: EDY69784.1.
PIR	S07246.
RefSeq	XP_002132382.1. XM_002132346.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6903503.
KEGG	dpo:Dpse_GA25223.
Organism-specific databases
FlyBase	FBgn0012689. Dpse\Adhr.
Phylogenomic databases
InParanoid	P81764.
OrthoDB	EOG44F4RW.
Family and domain databases
InterPro	IPR002427. ADH-rel. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01170. ADHRELATED. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADHR_DROPS

Accession

Primary (citable) accession number: P81764
Secondary accession number(s): B5DHK7, P26621, Q53WW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project