Reviewed, UniProtKB/Swiss-Prot P81764 (ADHR_DROPS)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase-related 31 kDa protein

Gene names

Name:	Adhr
Synonyms:	Adh-dup

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Complete proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: InterPro binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Alcohol dehydrogenase-related 31 kDa protein		PRO_0000054511
Regions
	Nucleotide binding	11 – 34	24	NAD or NADP By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Binding site	139	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81764-1 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 6FDE371F3D1AF774	FASTA	278	30,895
	10 20 30 40 50 60 MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF 70 80 90 100 110 120 WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL 130 140 150 160 170 180 PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM 190 200 210 220 230 240 AVCCGPTKVF VDRELTAFLE YGQSFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD 250 260 270 KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Adh gene region of Drosophila pseudoobscura: evolutionary change and evidence for an ancient gene duplication." Schaeffer S.W., Aquadro C.F. Genetics 117:61-73(1987) [PubMed: 3666441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular population genetics of sequence length diversity in the Adh region of Drosophila pseudoobscura." Schaeffer S.W. Genet. Res. 80:163-175(2002) [PubMed: 12688655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PS271.
[3]	"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y00602 Genomic DNA. Translation: CAA68646.1. U64535 Genomic DNA. Translation: AAL35977.1. CH379058 Genomic DNA. No translation available.
PIR	S07246.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0012689. Dpse\Adhr.
Family and domain databases
InterPro	IPR002427. ADH-rel. IPR002198. DH_sc/Rdtase_SDR. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01170. ADHRELATED. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADHR_DROPS

Accession

Primary (citable) accession number: P81764
Secondary accession number(s): P26621, Q53WW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project