Reviewed,
UniProtKB/Swiss-Prot P81748 (MIFH_TRITR)
Last modified
January 19, 2010.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Macrophage migration inhibitory factor homolog Short name=MIF EC=5.3.2.1 Alternative name(s): Phenylpyruvate tautomerase L-dopachrome tautomerase EC=5.3.3.12 L-dopachrome isomerase |
| Organism | Trichuris trichiura (Whipworm) |
| Taxonomic identifier | 36087 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Enoplea › Trichocephalida › Trichuridae › Trichuris |
Protein attributes
| Sequence length | 114 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Tautomerization of the methyl ester of L-dopachrome. Inhibits migration of human peripheral blood mononuclear cells By similarity. |
| Catalytic activity | L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. Ref.1 Keto-phenylpyruvate = enol-phenylpyruvate. Ref.1 |
| Subcellular location | Secreted By similarity. |
| Sequence similarities | Belongs to the MIF family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Molecular function | Cytokine Isomerase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW dopachrome isomerase activityInferred from electronic annotation. Source: EC phenylpyruvate tautomerase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.1 | ||||||
| Chain | 2 – 114 | 113 | Macrophage migration inhibitory factor homolog | PRO_0000158076 | |||||
Sites | |||||||||
| Active site | 2 | 1 | Proton acceptor; via imino nitrogen By similarity | ||||||
| Binding site | 33 | 1 | Substrate By similarity | ||||||
| Binding site | 98 | 1 | Substrate By similarity | ||||||
Sequences
References
| [1] | "Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis." Tan T.H.P., Edgerton S.A.V., Kumari R., McAlister M.S.B., Roe S.M., Nagl S., Pearl L.H., Selkirk M.E., Bianco A.E., Totty N.F., Engwerda C., Gray C.A., Meyer D.J., Rowe S.M. Biochem. J. 357:373-383(2001) [PubMed: 11439086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-34; 48-69 AND 80-109, CATALYTIC ACTIVITY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ237770 mRNA. Translation: CAB46355.1. |
3D structure databases | |
| SMR | P81748. Positions 1-114. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 5.3.3.12. 301024. |
Family and domain databases | |
| InterPro | IPR001398. Macrophage_inhib_fac. IPR014347. Tautomerase. [Graphical view] |
| Gene3D | G3DSA:3.30.429.10. Tautomerase. 1 hit. |
| PANTHER | PTHR11954. MIF. 1 hit. |
| Pfam | PF01187. MIF. 1 hit. [Graphical view] |
| ProDom | PD004816. Macrophage_inhib_fac. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS01158. MIF. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MIFH_TRITR | ||||||||
| Accession | Primary (citable) accession number: P81748 Secondary accession number(s): Q9U920 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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