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P81748

- MIFH_TRITR

UniProt

P81748 - MIFH_TRITR

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Protein
Macrophage migration inhibitory factor homolog
Gene
N/A
Organism
Trichuris trichiura (Whipworm) (Trichocephalus trichiurus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Tautomerization of the methyl ester of L-dopachrome. Inhibits migration of human peripheral blood mononuclear cells By similarity.

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.1 Publication
Keto-phenylpyruvate = enol-phenylpyruvate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Proton acceptor; via imino nitrogen By similarity
Binding sitei33 – 331Substrate By similarity
Binding sitei98 – 981Substrate By similarity

GO - Molecular functioni

  1. dopachrome isomerase activity Source: UniProtKB-EC
  2. phenylpyruvate tautomerase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage migration inhibitory factor homolog (EC:5.3.2.1)
Short name:
MIF
Alternative name(s):
L-dopachrome isomerase
L-dopachrome tautomerase (EC:5.3.3.12)
Phenylpyruvate tautomerase
OrganismiTrichuris trichiura (Whipworm) (Trichocephalus trichiurus)
Taxonomic identifieri36087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichocephalidaTrichuridaeTrichuris

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 114113Macrophage migration inhibitory factor homolog
PRO_0000158076Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP81748.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81748-1 [UniParc]FASTAAdd to Basket

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MPIFTFSTNV PSENISVDFL KSTSKLIAGM LGKPESYVAV HINGGQKITF    50
GGTDAPAGFG QLLSLGGVGG EKNRSHSAKL FKHLTDGLGI PGNRMYINFV 100
DMRGSDVGYN GSTF 114
Length:114
Mass (Da):12,043
Last modified:September 22, 2009 - v2
Checksum:i43B3BD9A9C77215B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ237770 mRNA. Translation: CAB46355.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ237770 mRNA. Translation: CAB46355.1 .

3D structure databases

ProteinModelPortali P81748.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001398. Macrophage_inhib_fac.
IPR014347. Tautomerase/MIF_sf.
[Graphical view ]
PANTHERi PTHR11954. PTHR11954. 1 hit.
Pfami PF01187. MIF. 1 hit.
[Graphical view ]
ProDomi PD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF55331. SSF55331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-34; 48-69 AND 80-109, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiMIFH_TRITR
AccessioniPrimary (citable) accession number: P81748
Secondary accession number(s): Q9U920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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