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P81748 (MIFH_TRITR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Macrophage migration inhibitory factor homolog

Short name=MIF
EC=5.3.2.1
Alternative name(s):
L-dopachrome isomerase
L-dopachrome tautomerase
EC=5.3.3.12
Phenylpyruvate tautomerase
OrganismTrichuris trichiura (Whipworm) (Trichocephalus trichiurus)
Taxonomic identifier36087 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaEnopleaDorylaimiaTrichocephalidaTrichuridaeTrichuris

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tautomerization of the methyl ester of L-dopachrome. Inhibits migration of human peripheral blood mononuclear cells By similarity.

Catalytic activity

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. Ref.1

Keto-phenylpyruvate = enol-phenylpyruvate. Ref.1

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the MIF family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionCytokine
Isomerase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondopachrome isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

phenylpyruvate tautomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 114113Macrophage migration inhibitory factor homolog
PRO_0000158076

Sites

Active site21Proton acceptor; via imino nitrogen By similarity
Binding site331Substrate By similarity
Binding site981Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P81748 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 43B3BD9A9C77215B

FASTA11412,043
        10         20         30         40         50         60 
MPIFTFSTNV PSENISVDFL KSTSKLIAGM LGKPESYVAV HINGGQKITF GGTDAPAGFG 

        70         80         90        100        110 
QLLSLGGVGG EKNRSHSAKL FKHLTDGLGI PGNRMYINFV DMRGSDVGYN GSTF 

« Hide

References

[1]"Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis."
Tan T.H.P., Edgerton S.A.V., Kumari R., McAlister M.S.B., Roe S.M., Nagl S., Pearl L.H., Selkirk M.E., Bianco A.E., Totty N.F., Engwerda C., Gray C.A., Meyer D.J., Rowe S.M.
Biochem. J. 357:373-383(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-34; 48-69 AND 80-109, CATALYTIC ACTIVITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ237770 mRNA. Translation: CAB46355.1.

3D structure databases

ProteinModelPortalP81748.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001398. Macrophage_inhib_fac.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERPTHR11954. PTHR11954. 1 hit.
PfamPF01187. MIF. 1 hit.
[Graphical view]
ProDomPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF55331. SSF55331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMIFH_TRITR
AccessionPrimary (citable) accession number: P81748
Secondary accession number(s): Q9U920
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families