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P81746

- TOG3D_AGEAP

UniProt

P81746 - TOG3D_AGEAP

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Protein

Omega-agatoxin-Aa3d

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions. In vertebrates, it is broadly active against all high-threshold Cav1/CACNA1 channels and Cav2.2/CACNA1B channels.

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa3d
Short name:
Omega-AGTX-Aa3d
Alternative name(s):
Omega-agatoxin IIID
Short name:
Omega-Aga-IIID
Omega-agatoxin-3D
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000181. omega-agatoxin-Aa3d (N-terminal fragment).

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›37›37Omega-agatoxin-Aa3dPRO_0000087609Add
BLAST

Post-translational modificationi

Disulfide bonds are present.Curated

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P81746-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
SCIKIGEDCD GDKDDCQCCR TNGYCSXYXL FGYLKSG
Length:37
Mass (Da):4,084
Last modified:September 26, 2001 - v1
Checksum:i89E46267B3846D93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371

Sequence databases

PIRiF54252.

Cross-referencesi

Sequence databases

PIRi F54252.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000181. omega-agatoxin-Aa3d (N-terminal fragment).

Family and domain databases

InterProi IPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view ]
Pfami PF08396. Toxin_34. 1 hit.
[Graphical view ]
PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels."
    Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.
    Biochemistry 33:5098-5108(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
    Tissue: Venom.

Entry informationi

Entry nameiTOG3D_AGEAP
AccessioniPrimary (citable) accession number: P81746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This toxin does not inhibit Cav3 (T-type) channels.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3