Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P81745 (TOG3C_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Omega-agatoxin-Aa3c

Short name=Omega-AGTX-Aa3c
Alternative name(s):
Omega-agatoxin IIIC
Short name=Omega-Aga-IIIC
Omega-agatoxin-3C
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length43 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Omega-agatoxins are antagonists of voltage-gated calcium channels By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similarities

Belongs to the omega-agatoxin superfamily. Type II/III omega-agatoxin family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›43›43Omega-agatoxin-Aa3c
PRO_0000087608

Amino acid modifications

Disulfide bond2 ↔ 19 Probable
Disulfide bond9 ↔ 25 Probable
Disulfide bond27 ↔ 38 Probable

Experimental info

Non-terminal residue431

Sequences

Sequence LengthMass (Da)Tools
P81745 [UniParc].

Last modified September 26, 2001. Version 1.
Checksum: 67DD548E58E0A29C

FASTA434,776
        10         20         30         40 
NCIDFGGDCD GEKDDCQCCX RNGYCSCYNL FGYLKRGCKX EVG 

« Hide

References

[1]"Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels."
Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.
Biochemistry 33:5098-5108(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRE54252.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000180. omega-agatoxin-Aa3c (N-terminal fragment).

Family and domain databases

InterProIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTOG3C_AGEAP
AccessionPrimary (citable) accession number: P81745
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families