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P81745

- TOG3C_AGEAP

UniProt

P81745 - TOG3C_AGEAP

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Protein
Omega-agatoxin-Aa3c
Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Omega-agatoxins are antagonists of voltage-gated calcium channels By similarity.

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa3c
Short name:
Omega-AGTX-Aa3c
Alternative name(s):
Omega-agatoxin IIIC
Short name:
Omega-Aga-IIIC
Omega-agatoxin-3C
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000180. omega-agatoxin-Aa3c (N-terminal fragment).

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›43›43Omega-agatoxin-Aa3c
PRO_0000087608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 19 Inferred
Disulfide bondi9 ↔ 25 Inferred
Disulfide bondi27 ↔ 38 Inferred

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P81745-1 [UniParc]FASTAAdd to Basket

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NCIDFGGDCD GEKDDCQCCX RNGYCSCYNL FGYLKRGCKX EVG          43
Length:43
Mass (Da):4,776
Last modified:September 26, 2001 - v1
Checksum:i67DD548E58E0A29C
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei43 – 431

Sequence databases

PIRiE54252.

Cross-referencesi

Sequence databases

PIRi E54252.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000180. omega-agatoxin-Aa3c (N-terminal fragment).

Family and domain databases

InterProi IPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view ]
Pfami PF08396. Toxin_34. 1 hit.
[Graphical view ]
PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels."
    Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.
    Biochemistry 33:5098-5108(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiTOG3C_AGEAP
AccessioniPrimary (citable) accession number: P81745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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