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P81744

- TOG3B_AGEAP

UniProt

P81744 - TOG3B_AGEAP

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Protein

Omega-agatoxin-Aa3b

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions. In vertebrates, it is broadly active against all high-threshold Cav1/CACNA1 channels and Cav2.2/CACNA1B channels.1 Publication

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa3b
Short name:
Omega-AGTX-Aa3b
Alternative name(s):
Omega-agatoxin IIIB
Short name:
Omega-Aga-IIIB
Omega-agatoxin-3B
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000179. omega-agatoxin-Aa3b.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Omega-agatoxin-Aa3bPRO_0000087607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 19Curated
Disulfide bondi9 ↔ 25Curated
Disulfide bondi16 ↔ 52Curated
Disulfide bondi18 ↔ 40Curated
Disulfide bondi27 ↔ 38Curated
Disulfide bondi59 ↔ 67Curated

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81744-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SCIDFGGDCD GEKDDCQCCR SNGYCSCYNL FGYLKSGCKC EVGTSAEFRR
60 70
ICRRKAKQCY NSDPDKCVSV YKPKRR
Length:76
Mass (Da):8,620
Last modified:June 1, 2001 - v1
Checksum:iD5C63C3AE8C95BB8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291N → S.1 Publication
Natural varianti35 – 351K → R.1 Publication

Sequence databases

PIRiB54252.
C54252.
D54252.

Cross-referencesi

Sequence databases

PIRi B54252.
C54252.
D54252.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000179. omega-agatoxin-Aa3b.

Family and domain databases

InterProi IPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view ]
Pfami PF08396. Toxin_34. 1 hit.
[Graphical view ]
PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels."
    Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.
    Biochemistry 33:5098-5108(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, VARIANTS SER-29 AND ARG-35, FUNCTION.
    Tissue: Venom.

Entry informationi

Entry nameiTOG3B_AGEAP
AccessioniPrimary (citable) accession number: P81744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This toxin does not inhibit Cav3 (T-type) channels.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3