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P81744 (TOG3B_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Omega-agatoxin-Aa3b

Short name=Omega-AGTX-Aa3b
Alternative name(s):
Omega-agatoxin IIIB
Short name=Omega-Aga-IIIB
Omega-agatoxin-3B
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions. In vertebrates, it is broadly active against all high-threshold Cav1/CACNA1 channels and Cav2.2/CACNA1B channels. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin Probable.

Miscellaneous

This toxin does not inhibit Cav3 (T-type) channels.

Sequence similarities

Belongs to the omega-agatoxin superfamily. Type II/III omega-agatoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7676Omega-agatoxin-Aa3b
PRO_0000087607

Amino acid modifications

Disulfide bond2 ↔ 19 Probable
Disulfide bond9 ↔ 25 Probable
Disulfide bond16 ↔ 52 Probable
Disulfide bond18 ↔ 40 Probable
Disulfide bond27 ↔ 38 Probable
Disulfide bond59 ↔ 67 Probable

Natural variations

Natural variant291N → S. Ref.1
Natural variant351K → R. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P81744 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D5C63C3AE8C95BB8

FASTA768,620
        10         20         30         40         50         60 
SCIDFGGDCD GEKDDCQCCR SNGYCSCYNL FGYLKSGCKC EVGTSAEFRR ICRRKAKQCY 

        70 
NSDPDKCVSV YKPKRR 

« Hide

References

[1]"Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels."
Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.
Biochemistry 33:5098-5108(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, VARIANTS SER-29 AND ARG-35, FUNCTION.
Tissue: Venom.

Cross-references

Sequence databases

PIRB54252.
C54252.
D54252.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000179. omega-agatoxin-Aa3b.

Family and domain databases

InterProIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTOG3B_AGEAP
AccessionPrimary (citable) accession number: P81744
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 16, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families