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P81744

- TOG3B_AGEAP

UniProt

P81744 - TOG3B_AGEAP

Protein

Omega-agatoxin-Aa3b

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Omega-agatoxins are antagonists of voltage-gated calcium channels. This toxin blocks calcium channels in insect central neurons but not at peripheral neuromuscular junctions. In vertebrates, it is broadly active against all high-threshold Cav1/CACNA1 channels and Cav2.2/CACNA1B channels.1 Publication

    Keywords - Molecular functioni

    Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Omega-agatoxin-Aa3b
    Short name:
    Omega-AGTX-Aa3b
    Alternative name(s):
    Omega-agatoxin IIIB
    Short name:
    Omega-Aga-IIIB
    Omega-agatoxin-3B
    OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
    Taxonomic identifieri6908 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

    Organism-specific databases

    ArachnoServeriAS000179. omega-agatoxin-Aa3b.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism presynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676Omega-agatoxin-Aa3bPRO_0000087607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 19Curated
    Disulfide bondi9 ↔ 25Curated
    Disulfide bondi16 ↔ 52Curated
    Disulfide bondi18 ↔ 40Curated
    Disulfide bondi27 ↔ 38Curated
    Disulfide bondi59 ↔ 67Curated

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated

    Sequence similaritiesi

    Keywords - Domaini

    Knottin

    Family and domain databases

    InterProiIPR005853. Omega-agatoxin_II/III_CS.
    IPR013605. Toxin_34.
    [Graphical view]
    PfamiPF08396. Toxin_34. 1 hit.
    [Graphical view]
    PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P81744-1 [UniParc]FASTAAdd to Basket

    « Hide

    SCIDFGGDCD GEKDDCQCCR SNGYCSCYNL FGYLKSGCKC EVGTSAEFRR   50
    ICRRKAKQCY NSDPDKCVSV YKPKRR 76
    Length:76
    Mass (Da):8,620
    Last modified:June 1, 2001 - v1
    Checksum:iD5C63C3AE8C95BB8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291N → S.1 Publication
    Natural varianti35 – 351K → R.1 Publication

    Sequence databases

    PIRiB54252.
    C54252.
    D54252.

    Cross-referencesi

    Sequence databases

    PIRi B54252.
    C54252.
    D54252.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ArachnoServeri AS000179. omega-agatoxin-Aa3b.

    Family and domain databases

    InterProi IPR005853. Omega-agatoxin_II/III_CS.
    IPR013605. Toxin_34.
    [Graphical view ]
    Pfami PF08396. Toxin_34. 1 hit.
    [Graphical view ]
    PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels."
      Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.
      Biochemistry 33:5098-5108(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, VARIANTS SER-29 AND ARG-35, FUNCTION.
      Tissue: Venom.

    Entry informationi

    Entry nameiTOG3B_AGEAP
    AccessioniPrimary (citable) accession number: P81744
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    This toxin does not inhibit Cav3 (T-type) channels.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3