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Protein

Disintegrin EMF10B

Gene
N/A
Organism
Eristicophis macmahoni (Leaf-nosed viper)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Extremely potent and selective inhibitor of integrin alpha-5/beta-1 (ITGA5/ITGB1). Partially inhibits adhesion of cells expressing alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-4/beta-1 (ITGA4/ITGB1) to appropriate ligands only at concentration higher than 500 nM. Weakly inhibits ADP-induced platelet aggregation.1 Publication

Miscellaneous

The disintegrin belongs to the dimeric disintegrin subfamily.

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin EMF10B
Short name:
EMF-10B
Alternative name(s):
Eristocophin II
Platelet aggregation activation inhibitor
OrganismiEristicophis macmahoni (Leaf-nosed viper)
Taxonomic identifieri110227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEristicophis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018041 – 68Disintegrin EMF10BAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 331 Publication
Disulfide bondi11Interchain (with C-8 in EMF10A)1 Publication
Disulfide bondi16Interchain (with C-13 in EMF10A)1 Publication
Disulfide bondi24 ↔ 301 Publication
Disulfide bondi29 ↔ 541 Publication
Disulfide bondi42 ↔ 611 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with EMF10A; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP81743.
SMRiP81743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 68DisintegrinAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 48Cell attachment site; atypical (MGD)3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P81743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ELLQNSGNPC CDPVTCKPRR GEHCVSGPCC DNCKFLNAGT VCWPAMGDWN
60
DDYCTGISSD CPRNPVFK
Length:68
Mass (Da):7,427
Last modified:May 30, 2000 - v1
Checksum:iE63FEE61BCE74220
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 8NSGN → ESAG AA sequence (PubMed:1494485).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti35F → K2 Publications1
Natural varianti65 – 68Missing . 4

Similar proteinsi

Entry informationi

Entry nameiVM2AB_ERIMA
AccessioniPrimary (citable) accession number: P81743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Eristocophin II appears to represent degradation product of EMF10B.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families