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Protein

Hemocyanin 2-c chain

Gene
N/A
Organism
Megathura crenulata (Giant keyhole limpet)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Copper ABy similarity
Metal bindingi66 – 661Copper ABy similarity
Metal bindingi73 – 731Copper ABy similarity
Metal bindingi185 – 1851Copper BBy similarity
Metal bindingi189 – 1891Copper BBy similarity
Metal bindingi216 – 2161Copper BBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemocyanin 2-c chain
Alternative name(s):
KLH2-c
OrganismiMegathura crenulata (Giant keyhole limpet)
Taxonomic identifieri55429 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaVetigastropodaFissurelloideaFissurellidaeMegathura

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Hemocyanin 2-c chainPRO_0000204289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 63By similarity
Disulfide bondi175 ↔ 242By similarity
Disulfide bondi335 ↔ 342By similarity

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Hemolymph.

Structurei

3D structure databases

ProteinModelPortaliP81732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
2.60.310.10. 1 hit.
InterProiIPR028999. Haemocyanin_beta-sandwich.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF14830. Haemocyan_bet_s. 1 hit.
PF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
SSF81277. SSF81277. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DFGHSKKIRK NVHSLTAEEQ NSLRRAMDDL QDDKTRGGFQ QIAAFHGEPK
60 70 80 90 100
WCPRPEAEKK FACCVHGMAV FPHWHRLLTV QGENALRKHG FTGGLPYWDW
110 120 130 140 150
TRPMSALPHF VADPTYDDSV SSLEEDNPYS HGHIDSVGHD TTRAVRDDLY
160 170 180 190 200
QSPGFGHYTD IAKQVLLALE QDDFCDFEVQ FEIAHNSIHA LVGGNEPYGM
210 220 230 240 250
STLEYFLYDP IFFLHHSNTD RLWAIWQALQ KYRGKPYNTA NCAIVRHDTY
260 270 280 290 300
RKPLQPFGLD SVINPDDETR EHSVPRDVFN YKDDFNYEYE SLNFNGLSIA
310 320 330 340 350
QLDRELQRIK SHDRVFAGFL LHEIGQSALV KFYVCKHHVS DCDHYAGEFY
360 370 380 390 400
ILGDEAEMPF AYDRVYKYEI SQALHDLDLH VGDNFHLKYE AFNLNGGSLG
410 420
GVDLSQPSVI FEPAAGSHTA
Length:420
Mass (Da):48,091
Last modified:March 1, 2001 - v1
Checksum:i512A99415CCA54B2
GO

Mass spectrometryi

Molecular mass is 56126±150 Da from positions 1 - 420. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP81732.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
2.60.310.10. 1 hit.
InterProiIPR028999. Haemocyanin_beta-sandwich.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF14830. Haemocyan_bet_s. 1 hit.
PF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
SSF81277. SSF81277. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHC2C_MEGCR
AccessioniPrimary (citable) accession number: P81732
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.