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Aminopeptidase N

Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli


Acts as a receptor for B.thuringiensis Cry1Ac delta-endotoxin.1 Publication

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.1 Publication


Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Inhibited by the zinc-chelators 2,2-dipyridyl and 1,10-phenanthroline.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi


Names & Taxonomyi

Protein namesi
Recommended name:
Aminopeptidase N (EC:
Short name:
Alternative name(s):
CryIA(C) receptor
OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifieri29058 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950861 – ›10Aminopeptidase N›10

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated


Sequence statusi: Fragment.

Mass (Da):1,093
Last modified:May 30, 2000 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei101


3D structure databases


Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases


Entry informationi

Entry nameiAMPN_HELAM
AccessioniPrimary (citable) accession number: P81731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)


Keywords - Technical termi

Direct protein sequencing


  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.