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P81706

- GSTA1_CAVPO

UniProt

P81706 - GSTA1_CAVPO

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Protein

Glutathione S-transferase A

Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A (EC:2.5.1.18)
Short name:
GST A
Alternative name(s):
Class-alpha
GGST A1-1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Glutathione S-transferase APRO_0000185782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylserine

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP81706.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000021161.

Structurei

3D structure databases

ProteinModelPortaliP81706.
SMRiP81706. Positions 3-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminalAdd
BLAST
Domaini84 – 206123GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
HOVERGENiHBG053749.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81706-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SGKPVLHYFN VQGRMESIRW LLAAAGVEFE EKLIMCQEDL DKLKNDGLLM
60 70 80 90 100
FQQVPMVEMD GMKMVQSRAI LNYIATKYNL YGKDTKERLL IDMYTEGMTD
110 120 130 140 150
LYELFFKVIL APPEEKDAAK SLIKDRAKNR FLPAFEKVLK SHGQGYLVGN
160 170 180 190 200
KLSKADILLT ELLYMVEEFD ASLLANFTLL QALKTRVSNL PNVKKFLQPG
210
SQRKPFPTQE MFEEMRKF
Length:218
Mass (Da):25,191
Last modified:December 1, 2000 - v1
Checksum:iADAF1F5661B88B2F
GO

Sequence databases

PIRiJX0294.

Cross-referencesi

Sequence databases

PIRi JX0294.

3D structure databases

ProteinModelPortali P81706.
SMRi P81706. Positions 3-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000021161.

Proteomic databases

PRIDEi P81706.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG266414.
HOVERGENi HBG053749.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of glutathione S-transferase a from guinea pig liver."
    Kamei-Hayashi K., Oshino R., Hara S.
    J. Biochem. 114:835-841(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: Hartley.
    Tissue: Liver.
  2. "Purification and characterization of glutathione S-transferases from guinea pig liver."
    Oshino R., Kamei K., Nishioka M., Shin M.
    J. Biochem. 107:105-110(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: Hartley.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA1_CAVPO
AccessioniPrimary (citable) accession number: P81706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3