Reviewed,
UniProtKB/Swiss-Prot P81706 (GSTA1_CAVPO)
Last modified
September 1, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutathione S-transferase A Short name=GST A EC=2.5.1.18 Alternative name(s): Class-alpha GGST A1-1 |
| Organism | Cavia porcellus (Guinea pig) |
| Taxonomic identifier | 10141 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia |
Protein attributes
| Sequence length | 218 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. |
| Catalytic activity | RX + glutathione = HX + R-S-glutathione. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Sequence similarities | Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glutathione transferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Amino acid sequence of glutathione S-transferase a from guinea pig liver." Kamei-Hayashi K., Oshino R., Hara S. J. Biochem. 114:835-841(1993) [PubMed: 8138540] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: Hartley. Tissue: Liver. |
| [2] | "Purification and characterization of glutathione S-transferases from guinea pig liver." Oshino R., Kamei K., Nishioka M., Shin M. J. Biochem. 107:105-110(1990) [PubMed: 2332412] [Abstract] Cited for: CHARACTERIZATION. Strain: Hartley. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| PIR | JX0294. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1K3O based on UniProtKB P08263. |
| SMR | P81706. Positions 3-217. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P81706. |
Genome annotation databases | |
| Ensembl | ENSCPOT00000027565; ENSCPOP00000021161; ENSCPOG00000004186; Cavia porcellus. [Genome view] |
Phylogenomic databases | |
| HOVERGEN | P81706. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.18. 44. |
Family and domain databases | |
| InterPro | IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| PANTHER | PTHR11571:SF4. GST_alpha. 1 hit. |
| Pfam | PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view] |
| PRINTS | PR01266. GSTRNSFRASEA. |
| PROSITE | PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GSTA1_CAVPO | ||||||||
| Accession | Primary (citable) accession number: P81706 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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