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P81706 (GSTA1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase A

Short name=GST A
EC=2.5.1.18
Alternative name(s):
Class-alpha
GGST A1-1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Glutathione S-transferase A
PRO_0000185782

Regions

Domain2 – 8281GST N-terminal
Domain84 – 206123GST C-terminal
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity

Amino acid modifications

Modified residue11N-acetylserine

Sequences

Sequence LengthMass (Da)Tools
P81706 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: ADAF1F5661B88B2F

FASTA21825,191
        10         20         30         40         50         60 
SGKPVLHYFN VQGRMESIRW LLAAAGVEFE EKLIMCQEDL DKLKNDGLLM FQQVPMVEMD 

        70         80         90        100        110        120 
GMKMVQSRAI LNYIATKYNL YGKDTKERLL IDMYTEGMTD LYELFFKVIL APPEEKDAAK 

       130        140        150        160        170        180 
SLIKDRAKNR FLPAFEKVLK SHGQGYLVGN KLSKADILLT ELLYMVEEFD ASLLANFTLL 

       190        200        210 
QALKTRVSNL PNVKKFLQPG SQRKPFPTQE MFEEMRKF 

« Hide

References

[1]"Amino acid sequence of glutathione S-transferase a from guinea pig liver."
Kamei-Hayashi K., Oshino R., Hara S.
J. Biochem. 114:835-841(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: Hartley.
Tissue: Liver.
[2]"Purification and characterization of glutathione S-transferases from guinea pig liver."
Oshino R., Kamei K., Nishioka M., Shin M.
J. Biochem. 107:105-110(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: Hartley.
Tissue: Liver.

Cross-references

Sequence databases

PIRJX0294.

3D structure databases

ProteinModelPortalP81706.
SMRP81706. Positions 3-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000021161.

Proteomic databases

PRIDEP81706.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG266414.
HOVERGENHBG053749.
InParanoidP81706.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11571:SF4. PTHR11571:SF4. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTA1_CAVPO
AccessionPrimary (citable) accession number: P81706
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 13, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families