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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

ACP1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Enzyme regulationi

Inhibited by sulfhydryl reagents (By similarity). Strongly inhibited by pyridoxal 5'-phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileBy similarity1
Active sitei19By similarity1
Active sitei130Proton donorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Short name:
LMW-PTP
Short name:
LMW-PTPase
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACP1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00000465602 – 158Low molecular weight phosphotyrosine protein phosphataseAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei132PhosphotyrosineBy similarity1
Modified residuei133PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP81693.
PeptideAtlasiP81693.
PRIDEiP81693.

Expressioni

Gene expression databases

BgeeiENSSSCG00000008659.
GenevisibleiP81693. SS.

Interactioni

Subunit structurei

Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009231.

Structurei

3D structure databases

ProteinModelPortaliP81693.
SMRiP81693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3217. Eukaryota.
COG0394. LUCA.
GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
HOVERGENiHBG007540.
InParanoidiP81693.
KOiK14394.
OMAiAGTGSWH.
OrthoDBiEOG091G0P0O.
TreeFamiTF353727.

Family and domain databases

InterProiView protein in InterPro
IPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQVTKSVL FVCLGNICRS PIAEAVFRKL VTDQNVSDNW VIDSSAVSDW
60 70 80 90 100
NVGRSPDPRA VSCLRHHGIN TAHKARQITK EDFATFDYIL CMDESNLRDL
110 120 130 140 150
NRKGNQVKNC RAKIELLGSY DPQKQLIIED PYYGNDSDFE AVYQQCVRCC

RAFLEKVR
Length:158
Mass (Da):18,035
Last modified:January 23, 2007 - v2
Checksum:i526AF176D24F86D2
GO

Sequence databases

RefSeqiXP_003481358.1. XM_003481310.2.
UniGeneiSsc.5115.

Genome annotation databases

EnsembliENSSSCT00000009474; ENSSSCP00000009231; ENSSSCG00000008659.
GeneIDi100737301.
KEGGissc:100737301.

Similar proteinsi

Entry informationi

Entry nameiPPAC_PIG
AccessioniPrimary (citable) accession number: P81693
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families