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P81693

- PPAC_PIG

UniProt

P81693 - PPAC_PIG

Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

ACP1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    A phosphate monoester + H2O = an alcohol + phosphate.

    Enzyme regulationi

    Inhibited by sulfhydryl reagents By similarity. Strongly inhibited by pyridoxal 5'-phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131NucleophileBy similarity
    Active sitei19 – 191By similarity
    Active sitei130 – 1301Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. non-membrane spanning protein tyrosine phosphatase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
    Short name:
    LMW-PTP
    Short name:
    LMW-PTPase
    Alternative name(s):
    Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
    Gene namesi
    Name:ACP1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 158157Low molecular weight phosphotyrosine protein phosphatasePRO_0000046560Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine
    Modified residuei132 – 1321PhosphotyrosineBy similarity
    Modified residuei133 – 1331PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP81693.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000009232.

    Structurei

    3D structure databases

    ProteinModelPortaliP81693.
    SMRiP81693. Positions 2-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    GeneTreeiENSGT00500000044891.
    HOGENOMiHOG000273094.
    HOVERGENiHBG007540.
    KOiK14394.
    OMAiDHRALAT.
    OrthoDBiEOG7QZGCG.
    TreeFamiTF353727.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR002115. Tyr_Pase_low_mol_wt_mml.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    PR00720. MAMMALPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P81693-1 [UniParc]FASTAAdd to Basket

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    MAEQVTKSVL FVCLGNICRS PIAEAVFRKL VTDQNVSDNW VIDSSAVSDW    50
    NVGRSPDPRA VSCLRHHGIN TAHKARQITK EDFATFDYIL CMDESNLRDL 100
    NRKGNQVKNC RAKIELLGSY DPQKQLIIED PYYGNDSDFE AVYQQCVRCC 150
    RAFLEKVR 158
    Length:158
    Mass (Da):18,035
    Last modified:January 23, 2007 - v2
    Checksum:i526AF176D24F86D2
    GO

    Sequence databases

    RefSeqiXP_003481358.1. XM_003481310.2.

    Genome annotation databases

    EnsembliENSSSCT00000009474; ENSSSCP00000009231; ENSSSCG00000008659.
    GeneIDi100737301.
    KEGGissc:100737301.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_003481358.1. XM_003481310.2.

    3D structure databases

    ProteinModelPortali P81693.
    SMRi P81693. Positions 2-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000009232.

    Proteomic databases

    PaxDbi P81693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000009474 ; ENSSSCP00000009231 ; ENSSSCG00000008659 .
    GeneIDi 100737301.
    KEGGi ssc:100737301.

    Phylogenomic databases

    eggNOGi COG0394.
    GeneTreei ENSGT00500000044891.
    HOGENOMi HOG000273094.
    HOVERGENi HBG007540.
    KOi K14394.
    OMAi DHRALAT.
    OrthoDBi EOG7QZGCG.
    TreeFami TF353727.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR002115. Tyr_Pase_low_mol_wt_mml.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    PR00720. MAMMALPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Porcine liver low M(r) phosphotyrosine protein phosphatase: the amino acid sequence."
      Caselli A., Pazzagli L., Paoli P., Manao G., Camici G., Cappugi G., Ramponi G.
      J. Protein Chem. 13:107-115(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-158.
      Tissue: Liver.

    Entry informationi

    Entry nameiPPAC_PIG
    AccessioniPrimary (citable) accession number: P81693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3