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P81693 (PPAC_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight phosphotyrosine protein phosphatase

Short name=LMW-PTP
Short name=LMW-PTPase
EC=3.1.3.48
Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2
Gene names
Name:ACP1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphate monoester + H2O = an alcohol + phosphate.

Enzyme regulation

Inhibited by sulfhydryl reagents By similarity. Strongly inhibited by pyridoxal 5'-phosphate.

Subunit structure

Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 158157Low molecular weight phosphotyrosine protein phosphatase
PRO_0000046560

Sites

Active site131Nucleophile By similarity
Active site191 By similarity
Active site1301Proton donor By similarity

Amino acid modifications

Modified residue21N-acetylalanine
Modified residue1321Phosphotyrosine By similarity
Modified residue1331Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P81693 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 526AF176D24F86D2

FASTA15818,035
        10         20         30         40         50         60 
MAEQVTKSVL FVCLGNICRS PIAEAVFRKL VTDQNVSDNW VIDSSAVSDW NVGRSPDPRA 

        70         80         90        100        110        120 
VSCLRHHGIN TAHKARQITK EDFATFDYIL CMDESNLRDL NRKGNQVKNC RAKIELLGSY 

       130        140        150 
DPQKQLIIED PYYGNDSDFE AVYQQCVRCC RAFLEKVR 

« Hide

References

[1]"Porcine liver low M(r) phosphotyrosine protein phosphatase: the amino acid sequence."
Caselli A., Pazzagli L., Paoli P., Manao G., Camici G., Cappugi G., Ramponi G.
J. Protein Chem. 13:107-115(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-158.
Tissue: Liver.

Cross-references

Sequence databases

RefSeqXP_003481358.1. XM_003481310.2.

3D structure databases

ProteinModelPortalP81693.
SMRP81693. Positions 2-158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000009232.

Proteomic databases

PaxDbP81693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000009474; ENSSSCP00000009231; ENSSSCG00000008659.
GeneID100737301.
KEGGssc:100737301.

Phylogenomic databases

eggNOGCOG0394.
GeneTreeENSGT00500000044891.
HOGENOMHOG000273094.
HOVERGENHBG007540.
KOK14394.
OMADHRALAT.
OrthoDBEOG7QZGCG.
TreeFamTF353727.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPAC_PIG
AccessionPrimary (citable) accession number: P81693
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families