P81693 (PPAC_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight phosphotyrosine protein phosphatase
Short name=LMW-PTP
Short name=LMW-PTPase
EC=3.1.3.48

Alternative name(s):
Low molecular weight cytosolic acid phosphatase
EC=3.1.3.2

Gene names

Name:

ACP1

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphate monoester + H2O = an alcohol + phosphate.
Enzyme regulation	Inhibited by sulfhydryl reagents By similarity. Strongly inhibited by pyridoxal 5'-phosphate.
Subunit structure	Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell internal side of plasma membrane Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC non-membrane spanning protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 158	157	Low molecular weight phosphotyrosine protein phosphatase		PRO_0000046560
Sites
	Active site	13	1	Nucleophile By similarity
	Active site	19	1	By similarity
	Active site	130	1	Proton donor By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine
	Modified residue	132	1	Phosphotyrosine By similarity
	Modified residue	133	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81693 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 526AF176D24F86D2	FASTA	158	18,035
	10 20 30 40 50 60 MAEQVTKSVL FVCLGNICRS PIAEAVFRKL VTDQNVSDNW VIDSSAVSDW NVGRSPDPRA 70 80 90 100 110 120 VSCLRHHGIN TAHKARQITK EDFATFDYIL CMDESNLRDL NRKGNQVKNC RAKIELLGSY 130 140 150 DPQKQLIIED PYYGNDSDFE AVYQQCVRCC RAFLEKVR

References

[1]	"Porcine liver low M(r) phosphotyrosine protein phosphatase: the amino acid sequence." Caselli A., Pazzagli L., Paoli P., Manao G., Camici G., Cappugi G., Ramponi G. J. Protein Chem. 13:107-115(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-158. Tissue: Liver.

Cross-references

Sequence databases
RefSeq	XP_003481358.1. XM_003481310.1.
3D structure databases
ProteinModelPortal	P81693.
SMR	P81693. Positions 2-158.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000009232.
Proteomic databases
PaxDb	P81693.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000009474; ENSSSCP00000009231; ENSSSCG00000008659.
GeneID	100737301.
KEGG	ssc:100737301.
Phylogenomic databases
eggNOG	COG0394.
GeneTree	ENSGT00500000044891.
HOGENOM	HOG000273094.
HOVERGEN	HBG007540.
KO	K14394.
OMA	WHEGEPA.
OrthoDB	EOG4DR9DN.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR002115. Tyr_Pase_low_mol_wt_mml. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE. PR00720. MAMMALPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPAC_PIG

Accession

Primary (citable) accession number: P81693

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program