Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P81693 (PPAC_PIG)

Last modified October 13, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Low molecular weight phosphotyrosine protein phosphatase
      Short name=LMW-PTPase
      Short name=LMW-PTP
    EC=3.1.3.48
Alternative name(s):
    Low molecular weight cytosolic acid phosphatase
    EC=3.1.3.2
Gene names
Name: ACP1
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphate monoester + H2O = an alcohol + phosphate.

Enzyme regulation

Inhibited by sulfhydryl reagents By similarity. Strongly inhibited by pyridoxal 5'-phosphate.

Subunit structure

Interacts with the SH3 domain of SPTAN1 By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 158157Low molecular weight phosphotyrosine protein phosphatase
PRO_0000046560

Sites

Active site131Nucleophile By similarity
Active site191 By similarity
Active site1301Proton donor By similarity

Amino acid modifications

Modified residue21N-acetylalanine
Modified residue1321Phosphotyrosine By similarity
Modified residue1331Phosphotyrosine By similarity
Modified residue1561N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P81693-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 526AF176D24F86D2

FASTA15818,035
        10         20         30         40         50         60 
MAEQVTKSVL FVCLGNICRS PIAEAVFRKL VTDQNVSDNW VIDSSAVSDW NVGRSPDPRA 

        70         80         90        100        110        120 
VSCLRHHGIN TAHKARQITK EDFATFDYIL CMDESNLRDL NRKGNQVKNC RAKIELLGSY 

       130        140        150 
DPQKQLIIED PYYGNDSDFE AVYQQCVRCC RAFLEKVR 

« Hide

References

[1]"Porcine liver low M(r) phosphotyrosine protein phosphatase: the amino acid sequence."
Caselli A., Pazzagli L., Paoli P., Manao G., Camici G., Cappugi G., Ramponi G.
J. Protein Chem. 13:107-115(1994) [PubMed: 8011064] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-158.
Tissue: Liver.

Cross-references

3D structure databases

HSSPHSSP built from PDB template 1DG9 based on UniProtKB P11064.
SMRP81693. Positions 2-158.
ModBaseSearch...

Phylogenomic databases

HOVERGENP81693.

Enzyme and pathway databases

BRENDA3.1.3.2. 249.
3.1.3.48. 249.

Family and domain databases

InterProIPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. Low_mwt_PTPase. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPAC_PIG
AccessionPrimary (citable) accession number: P81693
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: October 13, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents