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Protein

Venom allergen 5

Gene
N/A
Organism
Vespa mandarinia (Asian giant hornet)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5
Alternative name(s):
Antigen 5
Short name:
Ag5
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Vesp m 5
OrganismiVespa mandarinia (Asian giant hornet)
Taxonomic identifieri7446 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3526. Vesp m 5.0101.
678. Vesp m 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Venom allergen 5PRO_0000211543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 16By similarity
Disulfide bondi8 ↔ 101By similarity
Disulfide bondi26 ↔ 94By similarity
Disulfide bondi168 ↔ 185By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP81657.
SMRiP81657. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 187142SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NNYCKIKCRS GIHTLCKFGI STKPNCGKNV VKASGLTKAE KLEILKQHNE
60 70 80 90 100
FRQKVARGLE TRGKPGPQPP AKSMNTLVWN DELAQIAQVW AGQCDYGHDV
110 120 130 140 150
CRNTAKYSVG QNIAENGSTA ASFASVSNMV QMWADEVKNY QYGSTKNKLI
160 170 180 190 200
EVGHYTQMVW AKTKEIGCGS IKYIENGWHR HYLVCNYGPA GNIGNEPIYE

RK
Length:202
Mass (Da):22,547
Last modified:July 15, 1999 - v1
Checksum:i686351357B01F4EF
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP81657.
SMRiP81657. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3526. Vesp m 5.0101.
678. Vesp m 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Hoffman D.R., Schmidt J.O.
    Submitted (FEB-1998) to UniProtKB
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiVA5_VESMA
AccessioniPrimary (citable) accession number: P81657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.