ID   VA5_POLDO               Reviewed;         227 AA.
AC   P81656; Q68KJ8;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Antigen 5;
DE            Short=Ag5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Pol d 5;
DE   Flags: Precursor;
OS   Polistes dominula (European paper wasp) (Vespa dominula).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Polistini; Polistes.
OX   NCBI_TaxID=743375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Morris P.R., Schmidt M., Hoffman D.R.;
RT   "Nucleotide sequences of paper wasp venom antigen 5.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 22-227.
RC   TISSUE=Venom;
RA   Hoffman D.R.;
RL   Submitted (FEB-1999) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY685000; AAT95010.1; -; mRNA.
DR   RefSeq; NP_001310265.1; NM_001323336.1.
DR   AlphaFoldDB; P81656; -.
DR   SMR; P81656; -.
DR   Allergome; 3438; Pol d 5.0101.
DR   Allergome; 588; Pol d 5.
DR   EnsemblMetazoa; XM_015320485.1; XP_015175971.1; LOC107066143.
DR   GeneID; 107066143; -.
DR   OrthoDB; 1028426at2759; -.
DR   Proteomes; UP000694924; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd05380; CAP_euk; 1.
DR   Gene3D; 3.40.33.10; CAP; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; CYSTEINE-RICH SECRETORY PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10334:SF582; SCP DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; PR-1-like; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..227
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000211534"
FT   DOMAIN          69..212
FT                   /note="SCP"
FT   DISULFID        25..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        29..125
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        193..210
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  25446 MW;  F9FD14065F3E529B CRC64;
     MKISCLICLV IVLTIIHLSQ ANDYCKIKCS SGVHTVCQYG ESTKPSKNCA GKLIKSVGPT
     EEEKKLIVEE HNRFRQKVAK GLETRGNPGP QPAASNMNNL VWNDELAKIA QVWASQCQIL
     VHDKCRNTEK YQVGQNIAYA GSSNHFPSVT KLIQLWENEV KDFNYNTGIT NKNFGKVGHY
     TQMVWGNTKE VGCGSLKYVE KNMQIHYLIC NYGPAGNYLG QPIYTKK
//