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P81656 (VA5_POLDO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom allergen 5
Alternative name(s):
Antigen 5
Short name=Ag5
Cysteine-rich venom protein
Short name=CRVP
Allergen=Pol d 5
OrganismPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifier743375 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 227206Venom allergen 5
PRO_0000211534

Regions

Domain69 – 212144SCP

Amino acid modifications

Disulfide bond25 ↔ 37 By similarity
Disulfide bond29 ↔ 125 By similarity
Disulfide bond49 ↔ 117 By similarity
Disulfide bond193 ↔ 210 By similarity

Sequences

Sequence LengthMass (Da)Tools
P81656 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: F9FD14065F3E529B

FASTA22725,446
        10         20         30         40         50         60 
MKISCLICLV IVLTIIHLSQ ANDYCKIKCS SGVHTVCQYG ESTKPSKNCA GKLIKSVGPT 

        70         80         90        100        110        120 
EEEKKLIVEE HNRFRQKVAK GLETRGNPGP QPAASNMNNL VWNDELAKIA QVWASQCQIL 

       130        140        150        160        170        180 
VHDKCRNTEK YQVGQNIAYA GSSNHFPSVT KLIQLWENEV KDFNYNTGIT NKNFGKVGHY 

       190        200        210        220 
TQMVWGNTKE VGCGSLKYVE KNMQIHYLIC NYGPAGNYLG QPIYTKK 

« Hide

References

[1]"Nucleotide sequences of paper wasp venom antigen 5."
Morris P.R., Schmidt M., Hoffman D.R.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[2]Hoffman D.R.
Submitted (FEB-1999) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 22-227.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY685000 mRNA. Translation: AAT95010.1.

3D structure databases

ProteinModelPortalP81656.
SMRP81656. Positions 19-227.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3438. Pol d 5.0101.
588. Pol d 5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVA5_POLDO
AccessionPrimary (citable) accession number: P81656
Secondary accession number(s): Q68KJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: December 11, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries