P81656 (VA5_POLDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom allergen 5 Alternative name(s): Antigen 5 Short name=Ag5 Cysteine-rich venom protein Short name=CRVP Allergen=Pol d 5
Organism	Polistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifier	34728 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Polistinae › Polistini › Polistes

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 227	206	Venom allergen 5		PRO_0000211534
Regions
	Domain	69 – 212	144	SCP
Amino acid modifications
	Disulfide bond	25 ↔ 37		By similarity
	Disulfide bond	29 ↔ 125		By similarity
	Disulfide bond	49 ↔ 117		By similarity
	Disulfide bond	193 ↔ 210		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81656 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: F9FD14065F3E529B	FASTA	227	25,446
	10 20 30 40 50 60 MKISCLICLV IVLTIIHLSQ ANDYCKIKCS SGVHTVCQYG ESTKPSKNCA GKLIKSVGPT 70 80 90 100 110 120 EEEKKLIVEE HNRFRQKVAK GLETRGNPGP QPAASNMNNL VWNDELAKIA QVWASQCQIL 130 140 150 160 170 180 VHDKCRNTEK YQVGQNIAYA GSSNHFPSVT KLIQLWENEV KDFNYNTGIT NKNFGKVGHY 190 200 210 220 TQMVWGNTKE VGCGSLKYVE KNMQIHYLIC NYGPAGNYLG QPIYTKK

References

[1]	"Nucleotide sequences of paper wasp venom antigen 5." Morris P.R., Schmidt M., Hoffman D.R. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.
[2]	Hoffman D.R. Submitted (FEB-1999) to UniProtKB Cited for: PROTEIN SEQUENCE OF 22-227. Tissue: Venom.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY685000 mRNA. Translation: AAT95010.1.
3D structure databases
ProteinModelPortal	P81656.
SMR	P81656. Positions 19-227.
ModBase	Search...
Protein family/group databases
Allergome	3438. Pol d 5.0101. 588. Pol d 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.33.10. 1 hit.
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR014044. CAP_domain. IPR002413. V5_allergen. [Graphical view]
PANTHER	PTHR10334. PTHR10334. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00838. V5ALLERGEN. PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VA5_POLDO

Accession

Primary (citable) accession number: P81656
Secondary accession number(s): Q68KJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)