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P81656

- VA5_POLDO

UniProt

P81656 - VA5_POLDO

Protein

Venom allergen 5

Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Venom allergen 5
    Alternative name(s):
    Antigen 5
    Short name:
    Ag5
    Cysteine-rich venom protein
    Short name:
    CRVP
    Allergen: Pol d 5
    OrganismiPolistes dominula (European paper wasp) (Vespa dominula)
    Taxonomic identifieri743375 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3438. Pol d 5.0101.
    588. Pol d 5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 227206Venom allergen 5PRO_0000211534Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 37By similarity
    Disulfide bondi29 ↔ 125By similarity
    Disulfide bondi49 ↔ 117By similarity
    Disulfide bondi193 ↔ 210By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP81656.
    SMRiP81656. Positions 19-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 212144SCPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P81656-1 [UniParc]FASTAAdd to Basket

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    MKISCLICLV IVLTIIHLSQ ANDYCKIKCS SGVHTVCQYG ESTKPSKNCA    50
    GKLIKSVGPT EEEKKLIVEE HNRFRQKVAK GLETRGNPGP QPAASNMNNL 100
    VWNDELAKIA QVWASQCQIL VHDKCRNTEK YQVGQNIAYA GSSNHFPSVT 150
    KLIQLWENEV KDFNYNTGIT NKNFGKVGHY TQMVWGNTKE VGCGSLKYVE 200
    KNMQIHYLIC NYGPAGNYLG QPIYTKK 227
    Length:227
    Mass (Da):25,446
    Last modified:November 30, 2010 - v2
    Checksum:iF9FD14065F3E529B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY685000 mRNA. Translation: AAT95010.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY685000 mRNA. Translation: AAT95010.1 .

    3D structure databases

    ProteinModelPortali P81656.
    SMRi P81656. Positions 19-227.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3438. Pol d 5.0101.
    588. Pol d 5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR002413. V5_allergen.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of paper wasp venom antigen 5."
      Morris P.R., Schmidt M., Hoffman D.R.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.
    2. Hoffman D.R.
      Submitted (FEB-1999) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 22-227.
      Tissue: Venom.

    Entry informationi

    Entry nameiVA5_POLDO
    AccessioniPrimary (citable) accession number: P81656
    Secondary accession number(s): Q68KJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3