P81653 (FABPL_SCHBI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fatty acid-binding protein, liver

Alternative name(s):
Fatty acid-binding protein 1
Liver-type fatty acid-binding protein
Short name=L-FABP

Gene names

Name:

fabp1

Organism

Schroederichthys bivius (Narrowmouthed catshark) (Halaelurus bivius)

Taxonomic identifier

458609 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Chondrichthyes › Elasmobranchii › Selachii › Galeomorphii › Galeoidea › Carcharhiniformes › Scyliorhinidae › Schroederichthys

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Ligand	Lipid-binding
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 126	125	Fatty acid-binding protein, liver		PRO_0000067347
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81653 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 84A3690F87CCCE0B	FASTA	126	14,243
	10 20 30 40 50 60 MAFSGTWQVY SQENIEDFLR ALSLPEEVIK IGKDIKPVID IKQTGEHFVI VVKTSQQTVT 70 80 90 100 110 120 NEFTVGKEAE ITSMDGKKLK CTVQLEDGKL VAKKLKFTHI QEVQGNEMIE KLTAGNATMI RKSRRM

References

[1]

"The main fatty acid-binding protein in the liver of the shark (Halaetunus bivius) belongs to the liver basic type. Isolation, amino acid sequence determination and characterization." Cordoba O.L., Sanchez E.I., Santome J.A. Eur. J. Biochem. 265:832-838(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-126. Tissue: Liver.

Cross-references

3D structure databases
ProteinModelPortal	P81653.
SMR	P81653. Positions 3-126.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005633.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid-bd. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABPL_SCHBI

Accession

Primary (citable) accession number: P81653

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program