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Protein

Endoplasmic reticulum resident protein 29

Gene

ERP29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Gene namesi
Name:ERP29
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 258229Endoplasmic reticulum resident protein 29PRO_0000087030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphotyrosine; by PKDCCBy similarity
Modified residuei63 – 631Phosphotyrosine; by PKDCCBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP81623.
PRIDEiP81623.

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008754.

Structurei

3D structure databases

ProteinModelPortaliP81623.
SMRiP81623. Positions 30-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi255 – 2584Prevents secretion from ERPROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82861.
GeneTreeiENSGT00390000018566.
HOGENOMiHOG000046371.
HOVERGENiHBG051508.
InParanoidiP81623.
KOiK09586.
OMAiGEKYKLD.
OrthoDBiEOG7XH6RH.
TreeFamiTF324701.

Family and domain databases

Gene3Di1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFiPIRSF027352. ER_p29. 1 hit.
SUPFAMiSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAIPRAAS LSPLFPLLFL LSAPQDSSGL HTKGALPLDT ITFYKVIPKS
60 70 80 90 100
KFVLVKFDTQ YPYGEKQDEF KRLAENSASS DDLLVAEVGI SDYGDKLNME
110 120 130 140 150
LSEKYKLDKE NYPIFYLFQD GDFENPVLYS GAVKVGAIQR WLKGHGIYLG
160 170 180 190 200
MPGCLPAYDT LAGEFIRASG VEARQSLLKQ GQDNLASVKE TDKKWAEQYL
210 220 230 240 250
KIMGKILDQG EDFPASEMTR ITKLIEKNKM SDGKKEELQK SLNILTAFQK

KGGEKEEL
Length:258
Mass (Da):28,806
Last modified:April 3, 2007 - v2
Checksum:i32A15711043ECDC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411I → V AA sequence (PubMed:9738895).Curated
Sequence conflicti212 – 2121D → H AA sequence (PubMed:9738895).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118440 mRNA. Translation: AAI18441.1.
RefSeqiNP_001069739.1. NM_001076271.1.
UniGeneiBt.3152.

Genome annotation databases

EnsembliENSBTAT00000008754; ENSBTAP00000008754; ENSBTAG00000006665.
GeneIDi613357.
KEGGibta:613357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118440 mRNA. Translation: AAI18441.1.
RefSeqiNP_001069739.1. NM_001076271.1.
UniGeneiBt.3152.

3D structure databases

ProteinModelPortaliP81623.
SMRiP81623. Positions 30-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008754.

Proteomic databases

PaxDbiP81623.
PRIDEiP81623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008754; ENSBTAP00000008754; ENSBTAG00000006665.
GeneIDi613357.
KEGGibta:613357.

Organism-specific databases

CTDi10961.

Phylogenomic databases

eggNOGiNOG82861.
GeneTreeiENSGT00390000018566.
HOGENOMiHOG000046371.
HOVERGENiHBG051508.
InParanoidiP81623.
KOiK09586.
OMAiGEKYKLD.
OrthoDBiEOG7XH6RH.
TreeFamiTF324701.

Miscellaneous databases

NextBioi20898536.

Family and domain databases

Gene3Di1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFiPIRSF027352. ER_p29. 1 hit.
SUPFAMiSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.
  2. "ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif."
    Ferrari D.M., van Nguyen P., Kratzin H.D., Soeling H.D.
    Eur. J. Biochem. 255:570-579(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-50 AND 204-213.
    Tissue: Liver.

Entry informationi

Entry nameiERP29_BOVIN
AccessioniPrimary (citable) accession number: P81623
Secondary accession number(s): Q17QC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 3, 2007
Last modified: July 22, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.