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Protein

Endoplasmic reticulum resident protein 29

Gene

ERP29

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Gene namesi
Name:ERP29
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:28596 ERP29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000008703030 – 258Endoplasmic reticulum resident protein 29Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Phosphotyrosine; by PKDCCBy similarity1
Modified residuei63Phosphotyrosine; by PKDCCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP81623
PeptideAtlasiP81623
PRIDEiP81623

Expressioni

Gene expression databases

BgeeiENSBTAG00000006665

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008754

Structurei

3D structure databases

ProteinModelPortaliP81623
SMRiP81623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi255 – 258Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX2F Eukaryota
ENOG4111I8S LUCA
GeneTreeiENSGT00390000018566
HOGENOMiHOG000046371
HOVERGENiHBG051508
InParanoidiP81623
KOiK09586
OMAiDGCIKEF
OrthoDBiEOG091G0NH4
TreeFamiTF324701

Family and domain databases

CDDicd00238 ERp29c, 1 hit
cd03007 PDI_a_ERp29_N, 1 hit
Gene3Di1.20.1150.12, 1 hit
InterProiView protein in InterPro
IPR016855 ERp29
IPR011679 ERp29_C
IPR036356 ERp29_C_sf
IPR012883 ERp29_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF07749 ERp29, 1 hit
PF07912 ERp29_N, 1 hit
PIRSFiPIRSF027352 ER_p29, 1 hit
SUPFAMiSSF47933 SSF47933, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAIPRAAS LSPLFPLLFL LSAPQDSSGL HTKGALPLDT ITFYKVIPKS
60 70 80 90 100
KFVLVKFDTQ YPYGEKQDEF KRLAENSASS DDLLVAEVGI SDYGDKLNME
110 120 130 140 150
LSEKYKLDKE NYPIFYLFQD GDFENPVLYS GAVKVGAIQR WLKGHGIYLG
160 170 180 190 200
MPGCLPAYDT LAGEFIRASG VEARQSLLKQ GQDNLASVKE TDKKWAEQYL
210 220 230 240 250
KIMGKILDQG EDFPASEMTR ITKLIEKNKM SDGKKEELQK SLNILTAFQK

KGGEKEEL
Length:258
Mass (Da):28,806
Last modified:April 3, 2007 - v2
Checksum:i32A15711043ECDC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41I → V AA sequence (PubMed:9738895).Curated1
Sequence conflicti212D → H AA sequence (PubMed:9738895).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118440 mRNA Translation: AAI18441.1
RefSeqiNP_001069739.1, NM_001076271.1
UniGeneiBt.3152

Genome annotation databases

EnsembliENSBTAT00000008754; ENSBTAP00000008754; ENSBTAG00000006665
GeneIDi613357
KEGGibta:613357

Entry informationi

Entry nameiERP29_BOVIN
AccessioniPrimary (citable) accession number: P81623
Secondary accession number(s): Q17QC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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