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P81623

- ERP29_BOVIN

UniProt

P81623 - ERP29_BOVIN

Protein

Endoplasmic reticulum resident protein 29

Gene

ERP29

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER By similarity.By similarity

    GO - Biological processi

    1. protein secretion Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoplasmic reticulum resident protein 29
    Short name:
    ERp29
    Gene namesi
    Name:ERP29
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 258229Endoplasmic reticulum resident protein 29PRO_0000087030Add
    BLAST

    Proteomic databases

    PaxDbiP81623.
    PRIDEiP81623.

    Interactioni

    Subunit structurei

    Homodimer. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000008754.

    Structurei

    3D structure databases

    ProteinModelPortaliP81623.
    SMRiP81623. Positions 30-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi255 – 2584Prevents secretion from ERPROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82861.
    GeneTreeiENSGT00390000018566.
    HOGENOMiHOG000046371.
    HOVERGENiHBG051508.
    InParanoidiP81623.
    KOiK09586.
    OMAiPYGEKHE.
    OrthoDBiEOG7XH6RH.
    TreeFamiTF324701.

    Family and domain databases

    Gene3Di1.20.1150.12. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR016855. ER_p29.
    IPR011679. ER_p29_C.
    IPR012883. ERp29_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF07749. ERp29. 1 hit.
    PF07912. ERp29_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027352. ER_p29. 1 hit.
    SUPFAMiSSF47933. SSF47933. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P81623-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAIPRAAS LSPLFPLLFL LSAPQDSSGL HTKGALPLDT ITFYKVIPKS    50
    KFVLVKFDTQ YPYGEKQDEF KRLAENSASS DDLLVAEVGI SDYGDKLNME 100
    LSEKYKLDKE NYPIFYLFQD GDFENPVLYS GAVKVGAIQR WLKGHGIYLG 150
    MPGCLPAYDT LAGEFIRASG VEARQSLLKQ GQDNLASVKE TDKKWAEQYL 200
    KIMGKILDQG EDFPASEMTR ITKLIEKNKM SDGKKEELQK SLNILTAFQK 250
    KGGEKEEL 258
    Length:258
    Mass (Da):28,806
    Last modified:April 3, 2007 - v2
    Checksum:i32A15711043ECDC4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411I → V AA sequence (PubMed:9738895)Curated
    Sequence conflicti212 – 2121D → H AA sequence (PubMed:9738895)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118440 mRNA. Translation: AAI18441.1.
    RefSeqiNP_001069739.1. NM_001076271.1.
    UniGeneiBt.3152.

    Genome annotation databases

    EnsembliENSBTAT00000008754; ENSBTAP00000008754; ENSBTAG00000006665.
    GeneIDi613357.
    KEGGibta:613357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118440 mRNA. Translation: AAI18441.1 .
    RefSeqi NP_001069739.1. NM_001076271.1.
    UniGenei Bt.3152.

    3D structure databases

    ProteinModelPortali P81623.
    SMRi P81623. Positions 30-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000008754.

    Proteomic databases

    PaxDbi P81623.
    PRIDEi P81623.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008754 ; ENSBTAP00000008754 ; ENSBTAG00000006665 .
    GeneIDi 613357.
    KEGGi bta:613357.

    Organism-specific databases

    CTDi 10961.

    Phylogenomic databases

    eggNOGi NOG82861.
    GeneTreei ENSGT00390000018566.
    HOGENOMi HOG000046371.
    HOVERGENi HBG051508.
    InParanoidi P81623.
    KOi K09586.
    OMAi PYGEKHE.
    OrthoDBi EOG7XH6RH.
    TreeFami TF324701.

    Miscellaneous databases

    NextBioi 20898536.

    Family and domain databases

    Gene3Di 1.20.1150.12. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR016855. ER_p29.
    IPR011679. ER_p29_C.
    IPR012883. ERp29_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF07749. ERp29. 1 hit.
    PF07912. ERp29_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027352. ER_p29. 1 hit.
    SUPFAMi SSF47933. SSF47933. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons.
    2. "ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif."
      Ferrari D.M., van Nguyen P., Kratzin H.D., Soeling H.D.
      Eur. J. Biochem. 255:570-579(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 30-50 AND 204-213.
      Tissue: Liver.

    Entry informationi

    Entry nameiERP29_BOVIN
    AccessioniPrimary (citable) accession number: P81623
    Secondary accession number(s): Q17QC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    External Data

    Dasty 3