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P81623 (ERP29_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Endoplasmic reticulum resident protein 29
Short name=ERp29
Gene names
Name:ERP29
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER By similarity.

Subunit structure

Homodimer. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX By similarity.

Subcellular location

Endoplasmic reticulum lumen. Melanosome By similarity.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processprotein secretion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Compara

endoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

melanosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.2
Chain30 – 258229Endoplasmic reticulum resident protein 29
PRO_0000087030

Regions

Motif255 – 2584Prevents secretion from ER By similarity

Experimental info

Sequence conflict411I → V AA sequence Ref.2
Sequence conflict2121D → H AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P81623 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 32A15711043ECDC4

FASTA25828,806
        10         20         30         40         50         60 
MAAAIPRAAS LSPLFPLLFL LSAPQDSSGL HTKGALPLDT ITFYKVIPKS KFVLVKFDTQ 

        70         80         90        100        110        120 
YPYGEKQDEF KRLAENSASS DDLLVAEVGI SDYGDKLNME LSEKYKLDKE NYPIFYLFQD 

       130        140        150        160        170        180 
GDFENPVLYS GAVKVGAIQR WLKGHGIYLG MPGCLPAYDT LAGEFIRASG VEARQSLLKQ 

       190        200        210        220        230        240 
GQDNLASVKE TDKKWAEQYL KIMGKILDQG EDFPASEMTR ITKLIEKNKM SDGKKEELQK 

       250 
SLNILTAFQK KGGEKEEL

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.
[2]"ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif."
Ferrari D.M., van Nguyen P., Kratzin H.D., Soeling H.D.
Eur. J. Biochem. 255:570-579(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-50 AND 204-213.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC118440 mRNA. Translation: AAI18441.1.
IPIIPI00702891.
RefSeqNP_001069739.1. NM_001076271.1.
UniGeneBt.3152.

3D structure databases

ProteinModelPortalP81623.
SMRP81623. Positions 30-253.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000008754.

Proteomic databases

PaxDbP81623.
PRIDEP81623.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000008754; ENSBTAP00000008754; ENSBTAG00000006665.
GeneID613357.
KEGGbta:613357.

Organism-specific databases

CTD10961.

Phylogenomic databases

eggNOGNOG82861.
GeneTreeENSGT00390000018566.
HOGENOMHOG000046371.
HOVERGENHBG051508.
InParanoidP81623.
KOK09586.
OMATITFYKV.
OrthoDBEOG45QHF1.

Family and domain databases

Gene3D1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFPIRSF027352. ER_p29. 1 hit.
SUPFAMSSF47933. ERP29_C. 1 hit.
SSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20898536.

Entry information

Entry nameERP29_BOVIN
AccessionPrimary (citable) accession number: P81623
Secondary accession number(s): Q17QC3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 3, 2007
Last modified: April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
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