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P81623

- ERP29_BOVIN

UniProt

P81623 - ERP29_BOVIN

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Protein

Endoplasmic reticulum resident protein 29

Gene

ERP29

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity).By similarity

GO - Biological processi

  1. protein secretion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Gene namesi
Name:ERP29
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. endoplasmic reticulum lumen Source: InterPro
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 258229Endoplasmic reticulum resident protein 29PRO_0000087030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphotyrosine; by PKDCCBy similarity
Modified residuei63 – 631Phosphotyrosine; by PKDCCBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP81623.
PRIDEiP81623.

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008754.

Structurei

3D structure databases

ProteinModelPortaliP81623.
SMRiP81623. Positions 30-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi255 – 2584Prevents secretion from ERPROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82861.
GeneTreeiENSGT00390000018566.
HOGENOMiHOG000046371.
HOVERGENiHBG051508.
InParanoidiP81623.
KOiK09586.
OMAiPYGEKHE.
OrthoDBiEOG7XH6RH.
TreeFamiTF324701.

Family and domain databases

Gene3Di1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFiPIRSF027352. ER_p29. 1 hit.
SUPFAMiSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81623-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAIPRAAS LSPLFPLLFL LSAPQDSSGL HTKGALPLDT ITFYKVIPKS
60 70 80 90 100
KFVLVKFDTQ YPYGEKQDEF KRLAENSASS DDLLVAEVGI SDYGDKLNME
110 120 130 140 150
LSEKYKLDKE NYPIFYLFQD GDFENPVLYS GAVKVGAIQR WLKGHGIYLG
160 170 180 190 200
MPGCLPAYDT LAGEFIRASG VEARQSLLKQ GQDNLASVKE TDKKWAEQYL
210 220 230 240 250
KIMGKILDQG EDFPASEMTR ITKLIEKNKM SDGKKEELQK SLNILTAFQK

KGGEKEEL
Length:258
Mass (Da):28,806
Last modified:April 3, 2007 - v2
Checksum:i32A15711043ECDC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411I → V AA sequence (PubMed:9738895)Curated
Sequence conflicti212 – 2121D → H AA sequence (PubMed:9738895)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118440 mRNA. Translation: AAI18441.1.
RefSeqiNP_001069739.1. NM_001076271.1.
UniGeneiBt.3152.

Genome annotation databases

EnsembliENSBTAT00000008754; ENSBTAP00000008754; ENSBTAG00000006665.
GeneIDi613357.
KEGGibta:613357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC118440 mRNA. Translation: AAI18441.1 .
RefSeqi NP_001069739.1. NM_001076271.1.
UniGenei Bt.3152.

3D structure databases

ProteinModelPortali P81623.
SMRi P81623. Positions 30-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000008754.

Proteomic databases

PaxDbi P81623.
PRIDEi P81623.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000008754 ; ENSBTAP00000008754 ; ENSBTAG00000006665 .
GeneIDi 613357.
KEGGi bta:613357.

Organism-specific databases

CTDi 10961.

Phylogenomic databases

eggNOGi NOG82861.
GeneTreei ENSGT00390000018566.
HOGENOMi HOG000046371.
HOVERGENi HBG051508.
InParanoidi P81623.
KOi K09586.
OMAi PYGEKHE.
OrthoDBi EOG7XH6RH.
TreeFami TF324701.

Miscellaneous databases

NextBioi 20898536.

Family and domain databases

Gene3Di 1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF027352. ER_p29. 1 hit.
SUPFAMi SSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.
  2. "ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif."
    Ferrari D.M., van Nguyen P., Kratzin H.D., Soeling H.D.
    Eur. J. Biochem. 255:570-579(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-50 AND 204-213.
    Tissue: Liver.

Entry informationi

Entry nameiERP29_BOVIN
AccessioniPrimary (citable) accession number: P81623
Secondary accession number(s): Q17QC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3