ID   UCN1_MOUSE              Reviewed;         122 AA.
AC   P81615; O88390; Q14A76;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1999, sequence version 1.
DT   24-JAN-2024, entry version 145.
DE   RecName: Full=Urocortin;
DE   Flags: Precursor;
GN   Name=Ucn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9628819; DOI=10.1006/geno.1998.5292;
RA   Zhao L., Donaldson C.J., Smith G.W., Vale W.W.;
RT   "The structures of the mouse and human urocortin genes (Ucn and UCN).";
RL   Genomics 50:23-33(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=10690896; DOI=10.1210/jcem.85.2.6381;
RA   Slominski A., Roloff B., Curry J., Dahiya M., Szczesniewski A.,
RA   Wortsman J.;
RT   "The skin produces urocortin.";
RL   J. Clin. Endocrinol. Metab. 85:815-823(2000).
RN   [5]
RP   TISSUE SPECIFICITY, FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12091910; DOI=10.1038/ng914;
RA   Vetter D.E., Li C., Zhao L., Contarino A., Liberman M.C., Smith G.W.,
RA   Marchuk Y., Koob G.F., Heinemann S.F., Vale W., Lee K.F.;
RT   "Urocortin-deficient mice show hearing impairment and increased anxiety-
RT   like behavior.";
RL   Nat. Genet. 31:363-369(2002).
CC   -!- FUNCTION: Acts in vitro to stimulate the secretion of
CC       adrenocorticotropic hormone (ACTH) (By similarity). Binds with high
CC       affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity).
CC       Plays a role in the establishment of normal hearing thresholds
CC       (PubMed:12091910). Reduces food intake and regulates ghrelin levels in
CC       gastric body and plasma (By similarity). {ECO:0000250|UniProtKB:P55089,
CC       ECO:0000250|UniProtKB:P55090, ECO:0000269|PubMed:12091910}.
CC   -!- SUBUNIT: Interacts with CRHR1 and CRHR2 (via their N-terminal
CC       extracellular domain). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: In the organ of Corti, detected in the inner hair
CC       cell region (at protein level) (PubMed:12091910). Expressed in skin (at
CC       protein level) (PubMed:10690896). {ECO:0000269|PubMed:10690896,
CC       ECO:0000269|PubMed:12091910}.
CC   -!- DEVELOPMENTAL STAGE: In skin, levels decrease gradually from the
CC       telogen (resting) phase of the hair follicle with lowest levels
CC       observed in late anagen IV phase of active growth (at protein level).
CC       {ECO:0000269|PubMed:10690896}.
CC   -!- DISRUPTION PHENOTYPE: Increased anxiety-like behavior, reduced Crhr2
CC       mRNA levels in the lateral septum, normal basal feeding behavior, and
CC       hearing impairment at the level of the inner ear with shorter outer
CC       hair cells, higher threshold for auditory stimuli and higher distortion
CC       product otoacoustic emissions. {ECO:0000269|PubMed:12091910}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; AF038632; AAC24202.1; -; Genomic_DNA.
DR   EMBL; CH466524; EDL37339.1; -; Genomic_DNA.
DR   EMBL; BC116948; AAI16949.1; -; mRNA.
DR   EMBL; BC116950; AAI16951.1; -; mRNA.
DR   EMBL; BC144891; AAI44892.1; -; mRNA.
DR   CCDS; CCDS19174.1; -.
DR   RefSeq; NP_001332939.1; NM_001346010.1.
DR   RefSeq; NP_067265.1; NM_021290.2.
DR   AlphaFoldDB; P81615; -.
DR   SMR; P81615; -.
DR   STRING; 10090.ENSMUSP00000035321; -.
DR   PaxDb; 10090-ENSMUSP00000035321; -.
DR   ProteomicsDB; 297863; -.
DR   Antibodypedia; 4400; 246 antibodies from 31 providers.
DR   Ensembl; ENSMUST00000043475.7; ENSMUSP00000035321.3; ENSMUSG00000038676.7.
DR   Ensembl; ENSMUST00000201184.2; ENSMUSP00000144390.2; ENSMUSG00000038676.7.
DR   GeneID; 22226; -.
DR   KEGG; mmu:22226; -.
DR   UCSC; uc008wxe.1; mouse.
DR   AGR; MGI:1276123; -.
DR   CTD; 7349; -.
DR   MGI; MGI:1276123; Ucn.
DR   VEuPathDB; HostDB:ENSMUSG00000038676; -.
DR   eggNOG; ENOG502S63E; Eukaryota.
DR   GeneTree; ENSGT00940000154473; -.
DR   HOGENOM; CLU_138901_0_0_1; -.
DR   InParanoid; P81615; -.
DR   OMA; QNRIVFD; -.
DR   OrthoDB; 5353151at2759; -.
DR   PhylomeDB; P81615; -.
DR   TreeFam; TF332956; -.
DR   Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
DR   BioGRID-ORCS; 22226; 1 hit in 79 CRISPR screens.
DR   PRO; PR:P81615; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; P81615; Protein.
DR   Bgee; ENSMUSG00000038676; Expressed in hindlimb stylopod muscle and 17 other cell types or tissues.
DR   GO; GO:0030424; C:axon; ISO:MGI.
DR   GO; GO:0043679; C:axon terminus; ISO:MGI.
DR   GO; GO:0030425; C:dendrite; ISO:MGI.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0043204; C:perikaryon; ISO:MGI.
DR   GO; GO:0043196; C:varicosity; ISO:MGI.
DR   GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; ISO:MGI.
DR   GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; ISO:MGI.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR   GO; GO:0046811; F:histone deacetylase inhibitor activity; ISO:MGI.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0009060; P:aerobic respiration; ISO:MGI.
DR   GO; GO:0008306; P:associative learning; ISO:MGI.
DR   GO; GO:0042756; P:drinking behavior; ISO:MGI.
DR   GO; GO:0007631; P:feeding behavior; ISO:MGI.
DR   GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR   GO; GO:0007611; P:learning or memory; ISO:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0032099; P:negative regulation of appetite; ISO:MGI.
DR   GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR   GO; GO:0045792; P:negative regulation of cell size; ISO:MGI.
DR   GO; GO:2000252; P:negative regulation of feeding behavior; ISO:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR   GO; GO:0046888; P:negative regulation of hormone secretion; ISO:MGI.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:MGI.
DR   GO; GO:0031175; P:neuron projection development; ISO:MGI.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
DR   GO; GO:2000987; P:positive regulation of behavioral fear response; ISO:MGI.
DR   GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI.
DR   GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISO:MGI.
DR   GO; GO:0060452; P:positive regulation of cardiac muscle contraction; ISO:MGI.
DR   GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
DR   GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISO:MGI.
DR   GO; GO:0051461; P:positive regulation of corticotropin secretion; ISO:MGI.
DR   GO; GO:0045740; P:positive regulation of DNA replication; ISO:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045727; P:positive regulation of translation; ISO:MGI.
DR   GO; GO:0043117; P:positive regulation of vascular permeability; ISO:MGI.
DR   GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISO:MGI.
DR   GO; GO:0010996; P:response to auditory stimulus; IMP:UniProtKB.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   GO; GO:0006979; P:response to oxidative stress; ISO:MGI.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   GO; GO:0035176; P:social behavior; ISO:MGI.
DR   GO; GO:0001964; P:startle response; IMP:UniProtKB.
DR   GO; GO:0042311; P:vasodilation; ISO:MGI.
DR   Gene3D; 6.10.250.1920; -; 1.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; CORTICOLIBERIN/UROCORTIN; 1.
DR   PANTHER; PTHR15035:SF11; UROCORTIN; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
DR   Genevisible; P81615; MM.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Hearing; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..80
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006235"
FT   PEPTIDE         81..120
FT                   /note="Urocortin"
FT                   /id="PRO_0000006236"
FT   MOD_RES         120
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   122 AA;  13558 MW;  D2969756F36F5DEA CRC64;
     MIQRGRATLL VALLLLAQLR PESSQWSPAA AAATGVQDPN LRWSPGVRNQ GGGVRALLLL
     LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV
     GK
//