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P81615 (UCN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urocortin
Gene names
Name:Ucn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length122 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.

Subunit structure

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain) By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of protein kinase A activity

Inferred from electronic annotation. Source: Ensembl

aerobic respiration

Inferred from electronic annotation. Source: Ensembl

associative learning

Inferred from electronic annotation. Source: Ensembl

drinking behavior

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

gastric emptying

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of appetite

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell size

Inferred from electronic annotation. Source: Ensembl

negative regulation of feeding behavior

Inferred from electronic annotation. Source: Ensembl

negative regulation of gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of necrotic cell death

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron death

Inferred from electronic annotation. Source: Ensembl

neuron projection development

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: Ensembl

pancreatic juice secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of behavioral fear response

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion import

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of corticotropin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular permeability

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

regulation of synaptic transmission, glutamatergic

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

response to pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

perikaryon

Inferred from electronic annotation. Source: Ensembl

varicosity

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhistone deacetylase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 8055 By similarity
PRO_0000006235
Peptide81 – 12040Urocortin
PRO_0000006236

Amino acid modifications

Modified residue1201Valine amide By similarity

Sequences

Sequence LengthMass (Da)Tools
P81615 [UniParc].

Last modified January 1, 1999. Version 1.
Checksum: D2969756F36F5DEA

FASTA12213,558
        10         20         30         40         50         60 
MIQRGRATLL VALLLLAQLR PESSQWSPAA AAATGVQDPN LRWSPGVRNQ GGGVRALLLL 

        70         80         90        100        110        120 
LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV 


GK 

« Hide

References

[1]"The structures of the mouse and human urocortin genes (Ucn and UCN)."
Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038632 Genomic DNA. Translation: AAC24202.1.
CCDSCCDS19174.1.
RefSeqNP_067265.1. NM_021290.2.
UniGeneMm.377116.

3D structure databases

ProteinModelPortalP81615.
SMRP81615. Positions 81-120.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP81615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
GeneID22226.
KEGGmmu:22226.
UCSCuc008wxe.1. mouse.

Organism-specific databases

CTD7349.
MGIMGI:1276123. Ucn.

Phylogenomic databases

eggNOGNOG46022.
HOGENOMHOG000121779.
HOVERGENHBG036241.
InParanoidP81615.
OMALRWSPGA.
OrthoDBEOG73JKZD.
PhylomeDBP81615.
TreeFamTF332956.

Gene expression databases

BgeeP81615.
CleanExMM_UCN.
GenevestigatorP81615.

Family and domain databases

InterProIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERPTHR15035. PTHR15035. 1 hit.
PfamPF00473. CRF. 1 hit.
[Graphical view]
PRINTSPR01612. CRFFAMILY.
SMARTSM00039. CRF. 1 hit.
[Graphical view]
PROSITEPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302255.
PROP81615.
SOURCESearch...

Entry information

Entry nameUCN1_MOUSE
AccessionPrimary (citable) accession number: P81615
Secondary accession number(s): O88390
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1999
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot