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P81615

- UCN1_MOUSE

UniProt

P81615 - UCN1_MOUSE

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Protein
Urocortin
Gene
Ucn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.

GO - Molecular functioni

  1. histone deacetylase inhibitor activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase A activity Source: Ensembl
  2. aerobic respiration Source: Ensembl
  3. associative learning Source: Ensembl
  4. drinking behavior Source: Ensembl
  5. female pregnancy Source: Ensembl
  6. gastric emptying Source: Ensembl
  7. inflammatory response Source: Ensembl
  8. negative regulation of apoptotic process Source: Ensembl
  9. negative regulation of appetite Source: Ensembl
  10. negative regulation of blood pressure Source: Ensembl
  11. negative regulation of cell size Source: Ensembl
  12. negative regulation of feeding behavior Source: Ensembl
  13. negative regulation of gastric acid secretion Source: Ensembl
  14. negative regulation of gene expression Source: Ensembl
  15. negative regulation of hormone secretion Source: Ensembl
  16. negative regulation of necrotic cell death Source: Ensembl
  17. negative regulation of neuron death Source: Ensembl
  18. neuron projection development Source: Ensembl
  19. neuropeptide signaling pathway Source: Ensembl
  20. pancreatic juice secretion Source: Ensembl
  21. positive regulation of DNA replication Source: Ensembl
  22. positive regulation of behavioral fear response Source: Ensembl
  23. positive regulation of cAMP biosynthetic process Source: Ensembl
  24. positive regulation of calcium ion import Source: Ensembl
  25. positive regulation of cardiac muscle contraction Source: Ensembl
  26. positive regulation of cell growth Source: Ensembl
  27. positive regulation of collagen biosynthetic process Source: Ensembl
  28. positive regulation of corticotropin secretion Source: Ensembl
  29. positive regulation of gene expression Source: Ensembl
  30. positive regulation of interleukin-6 production Source: Ensembl
  31. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  32. positive regulation of translation Source: Ensembl
  33. positive regulation of vascular permeability Source: Ensembl
  34. positive regulation of vasodilation Source: Ensembl
  35. regulation of synaptic transmission, glutamatergic Source: Ensembl
  36. response to estradiol Source: Ensembl
  37. response to glucocorticoid Source: Ensembl
  38. response to oxidative stress Source: Ensembl
  39. response to pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Gene namesi
Name:Ucn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1276123. Ucn.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular region Source: UniProtKB-SubCell
  4. perikaryon Source: Ensembl
  5. varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 8055 By similarity
PRO_0000006235Add
BLAST
Peptidei81 – 12040Urocortin
PRO_0000006236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201Valine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiP81615.

Expressioni

Gene expression databases

BgeeiP81615.
CleanExiMM_UCN.
GenevestigatoriP81615.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain) By similarity.

Structurei

3D structure databases

ProteinModelPortaliP81615.
SMRiP81615. Positions 81-120.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46022.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP81615.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP81615.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81615-1 [UniParc]FASTAAdd to Basket

« Hide

MIQRGRATLL VALLLLAQLR PESSQWSPAA AAATGVQDPN LRWSPGVRNQ    50
GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL 100
ARTQSQRERA EQNRIIFDSV GK 122
Length:122
Mass (Da):13,558
Last modified:January 1, 1999 - v1
Checksum:iD2969756F36F5DEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038632 Genomic DNA. Translation: AAC24202.1.
CCDSiCCDS19174.1.
RefSeqiNP_067265.1. NM_021290.2.
UniGeneiMm.377116.

Genome annotation databases

EnsembliENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
GeneIDi22226.
KEGGimmu:22226.
UCSCiuc008wxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038632 Genomic DNA. Translation: AAC24202.1 .
CCDSi CCDS19174.1.
RefSeqi NP_067265.1. NM_021290.2.
UniGenei Mm.377116.

3D structure databases

ProteinModelPortali P81615.
SMRi P81615. Positions 81-120.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P81615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043475 ; ENSMUSP00000035321 ; ENSMUSG00000038676 .
GeneIDi 22226.
KEGGi mmu:22226.
UCSCi uc008wxe.1. mouse.

Organism-specific databases

CTDi 7349.
MGIi MGI:1276123. Ucn.

Phylogenomic databases

eggNOGi NOG46022.
HOGENOMi HOG000121779.
HOVERGENi HBG036241.
InParanoidi P81615.
OMAi LRWSPGA.
OrthoDBi EOG73JKZD.
PhylomeDBi P81615.
TreeFami TF332956.

Miscellaneous databases

NextBioi 302255.
PROi P81615.
SOURCEi Search...

Gene expression databases

Bgeei P81615.
CleanExi MM_UCN.
Genevestigatori P81615.

Family and domain databases

InterProi IPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view ]
PANTHERi PTHR15035. PTHR15035. 1 hit.
Pfami PF00473. CRF. 1 hit.
[Graphical view ]
PRINTSi PR01612. CRFFAMILY.
SMARTi SM00039. CRF. 1 hit.
[Graphical view ]
PROSITEi PS00511. CRF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The structures of the mouse and human urocortin genes (Ucn and UCN)."
    Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
    Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiUCN1_MOUSE
AccessioniPrimary (citable) accession number: P81615
Secondary accession number(s): O88390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1999
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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