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Protein

Urocortin

Gene

Ucn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (By similarity). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (PubMed:12091910). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).By similarity1 Publication

GO - Molecular functioni

  1. histone deacetylase inhibitor activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase A activity Source: Ensembl
  2. aerobic respiration Source: Ensembl
  3. associative learning Source: Ensembl
  4. drinking behavior Source: Ensembl
  5. female pregnancy Source: Ensembl
  6. gastric emptying Source: Ensembl
  7. inflammatory response Source: Ensembl
  8. negative regulation of apoptotic process Source: Ensembl
  9. negative regulation of appetite Source: Ensembl
  10. negative regulation of blood pressure Source: Ensembl
  11. negative regulation of cell size Source: Ensembl
  12. negative regulation of feeding behavior Source: Ensembl
  13. negative regulation of gastric acid secretion Source: Ensembl
  14. negative regulation of gene expression Source: Ensembl
  15. negative regulation of hormone secretion Source: Ensembl
  16. negative regulation of necrotic cell death Source: Ensembl
  17. negative regulation of neuron death Source: Ensembl
  18. neuron projection development Source: Ensembl
  19. neuropeptide signaling pathway Source: Ensembl
  20. pancreatic juice secretion Source: Ensembl
  21. positive regulation of behavioral fear response Source: Ensembl
  22. positive regulation of calcium ion import Source: Ensembl
  23. positive regulation of cAMP biosynthetic process Source: Ensembl
  24. positive regulation of cardiac muscle contraction Source: Ensembl
  25. positive regulation of cell growth Source: Ensembl
  26. positive regulation of collagen biosynthetic process Source: Ensembl
  27. positive regulation of corticotropin secretion Source: Ensembl
  28. positive regulation of DNA replication Source: Ensembl
  29. positive regulation of interleukin-6 production Source: Ensembl
  30. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  31. positive regulation of translation Source: Ensembl
  32. positive regulation of vascular permeability Source: Ensembl
  33. positive regulation of vasodilation Source: Ensembl
  34. regulation of synaptic transmission, glutamatergic Source: Ensembl
  35. response to estradiol Source: Ensembl
  36. response to glucocorticoid Source: Ensembl
  37. response to oxidative stress Source: Ensembl
  38. response to pain Source: Ensembl
  39. sensory perception of sound Source: UniProtKB-KW
  40. social behavior Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Gene namesi
Name:Ucn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1276123. Ucn.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular region Source: UniProtKB-SubCell
  4. perikaryon Source: Ensembl
  5. varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Increased anxiety-like behavior, reduced Crhr2 mRNA levels in the lateral septum, normal basal feeding behavior, and hearing impairment at the level of the inner ear with shorter outer hair cells, higher threshold for auditory stimuli and higher distortion product otoacoustic emissions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 8055By similarityPRO_0000006235Add
BLAST
Peptidei81 – 12040UrocortinPRO_0000006236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201Valine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiP81615.

Expressioni

Tissue specificityi

In the organ of Corti, detected in the inner hair cell region (at protein level) (PubMed:12091910). Expressed in skin (at protein level) (PubMed:10690896).2 Publications

Developmental stagei

In skin, levels decrease gradually from the telogen (resting) phase of the hair follicle with lowest levels observed in late anagen IV phase of active growth (at protein level).1 Publication

Gene expression databases

BgeeiP81615.
CleanExiMM_UCN.
ExpressionAtlasiP81615. baseline.
GenevestigatoriP81615.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035321.

Structurei

3D structure databases

ProteinModelPortaliP81615.
SMRiP81615. Positions 81-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46022.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP81615.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP81615.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQRGRATLL VALLLLAQLR PESSQWSPAA AAATGVQDPN LRWSPGVRNQ
60 70 80 90 100
GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL
110 120
ARTQSQRERA EQNRIIFDSV GK
Length:122
Mass (Da):13,558
Last modified:December 31, 1998 - v1
Checksum:iD2969756F36F5DEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038632 Genomic DNA. Translation: AAC24202.1.
CH466524 Genomic DNA. Translation: EDL37339.1.
BC116948 mRNA. Translation: AAI16949.1.
BC116950 mRNA. Translation: AAI16951.1.
BC144891 mRNA. Translation: AAI44892.1.
CCDSiCCDS19174.1.
RefSeqiNP_067265.1. NM_021290.2.
UniGeneiMm.377116.

Genome annotation databases

EnsembliENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
GeneIDi22226.
KEGGimmu:22226.
UCSCiuc008wxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038632 Genomic DNA. Translation: AAC24202.1.
CH466524 Genomic DNA. Translation: EDL37339.1.
BC116948 mRNA. Translation: AAI16949.1.
BC116950 mRNA. Translation: AAI16951.1.
BC144891 mRNA. Translation: AAI44892.1.
CCDSiCCDS19174.1.
RefSeqiNP_067265.1. NM_021290.2.
UniGeneiMm.377116.

3D structure databases

ProteinModelPortaliP81615.
SMRiP81615. Positions 81-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035321.

Proteomic databases

PRIDEiP81615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
GeneIDi22226.
KEGGimmu:22226.
UCSCiuc008wxe.1. mouse.

Organism-specific databases

CTDi7349.
MGIiMGI:1276123. Ucn.

Phylogenomic databases

eggNOGiNOG46022.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP81615.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP81615.
TreeFamiTF332956.

Miscellaneous databases

NextBioi302255.
PROiP81615.
SOURCEiSearch...

Gene expression databases

BgeeiP81615.
CleanExiMM_UCN.
ExpressionAtlasiP81615. baseline.
GenevestigatoriP81615.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The structures of the mouse and human urocortin genes (Ucn and UCN)."
    Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
    Genomics 50:23-33(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior."
    Vetter D.E., Li C., Zhao L., Contarino A., Liberman M.C., Smith G.W., Marchuk Y., Koob G.F., Heinemann S.F., Vale W., Lee K.F.
    Nat. Genet. 31:363-369(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiUCN1_MOUSE
AccessioniPrimary (citable) accession number: P81615
Secondary accession number(s): O88390, Q14A76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: December 31, 1998
Last modified: March 31, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.