P81615 (UCN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urocortin

Gene names

Name:

Ucn

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	122 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.
Subunit structure	Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain) By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of protein kinase A activity Inferred from electronic annotation. Source: Compara aerobic respiration Inferred from electronic annotation. Source: Compara associative learning Inferred from electronic annotation. Source: Compara drinking behavior Inferred from electronic annotation. Source: Compara female pregnancy Inferred from electronic annotation. Source: Compara gastric emptying Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of appetite Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of cell size Inferred from electronic annotation. Source: Compara negative regulation of feeding behavior Inferred from electronic annotation. Source: Compara negative regulation of gastric acid secretion Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of hormone secretion Inferred from electronic annotation. Source: Compara negative regulation of neuron death Inferred from electronic annotation. Source: Compara neuron projection development Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from electronic annotation. Source: Compara pancreatic juice secretion Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from electronic annotation. Source: Compara positive regulation of behavioral fear response Inferred from electronic annotation. Source: Compara positive regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of calcium ion import Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle contraction Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of collagen biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of corticotropin secretion Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of translation Inferred from electronic annotation. Source: Compara positive regulation of vascular permeability Inferred from electronic annotation. Source: Compara positive regulation of vasodilation Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to oxidative stress Inferred from electronic annotation. Source: Compara response to pain Inferred from electronic annotation. Source: Compara
Cellular_component	axon terminus Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell perikaryon Inferred from electronic annotation. Source: Compara varicosity Inferred from electronic annotation. Source: Compara
Molecular_function	histone deacetylase inhibitor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 80	55	By similarity		PRO_0000006235
	Peptide	81 – 120	40	Urocortin		PRO_0000006236
Amino acid modifications
	Modified residue	120	1	Valine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81615 [UniParc]. Last modified January 1, 1999. Version 1. Checksum: D2969756F36F5DEA	FASTA	122	13,558
	10 20 30 40 50 60 MIQRGRATLL VALLLLAQLR PESSQWSPAA AAATGVQDPN LRWSPGVRNQ GGGVRALLLL 70 80 90 100 110 120 LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL ARTQSQRERA EQNRIIFDSV GK

References

[1]	"The structures of the mouse and human urocortin genes (Ucn and UCN)." Zhao L., Donaldson C.J., Smith G.W., Vale W.W. Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF038632 Genomic DNA. Translation: AAC24202.1.
IPI	IPI00123680.
RefSeq	NP_067265.1. NM_021290.2.
UniGene	Mm.377116.
3D structure databases
ProteinModelPortal	P81615.
SMR	P81615. Positions 81-120.
ModBase	Search...
Proteomic databases
PRIDE	P81615.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
GeneID	22226.
KEGG	mmu:22226.
Organism-specific databases
CTD	7349.
MGI	MGI:1276123. Ucn.
Phylogenomic databases
eggNOG	NOG46022.
HOGENOM	HOG000121779.
HOVERGEN	HBG036241.
InParanoid	P81615.
OMA	AGVQDPS.
OrthoDB	EOG4KWJVG.
Gene expression databases
ArrayExpress	P81615.
Bgee	P81615.
CleanEx	MM_UCN.
Genevestigator	P81615.
GermOnline	ENSMUSG00000038676. Mus musculus.
Family and domain databases
InterPro	IPR018446. Corticotropin-releasing_fac_CS. IPR000187. Corticotropin-releasing_factor. IPR003620. Urocortin_CRF. [Graphical view]
PANTHER	PTHR15035. PTHR15035. 1 hit.
Pfam	PF00473. CRF. 1 hit. [Graphical view]
PRINTS	PR01612. CRFFAMILY.
SMART	SM00039. CRF. 1 hit. [Graphical view]
PROSITE	PS00511. CRF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	302255.
SOURCE	Search...

Entry information

Entry name

UCN1_MOUSE

Accession

Primary (citable) accession number: P81615
Secondary accession number(s): O88390

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1999
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program