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P81615

- UCN1_MOUSE

UniProt

P81615 - UCN1_MOUSE

Protein

Urocortin

Gene

Ucn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.

    GO - Molecular functioni

    1. histone deacetylase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. activation of protein kinase A activity Source: Ensembl
    2. aerobic respiration Source: Ensembl
    3. associative learning Source: Ensembl
    4. drinking behavior Source: Ensembl
    5. female pregnancy Source: Ensembl
    6. gastric emptying Source: Ensembl
    7. inflammatory response Source: Ensembl
    8. negative regulation of apoptotic process Source: Ensembl
    9. negative regulation of appetite Source: Ensembl
    10. negative regulation of blood pressure Source: Ensembl
    11. negative regulation of cell size Source: Ensembl
    12. negative regulation of feeding behavior Source: Ensembl
    13. negative regulation of gastric acid secretion Source: Ensembl
    14. negative regulation of gene expression Source: Ensembl
    15. negative regulation of hormone secretion Source: Ensembl
    16. negative regulation of necrotic cell death Source: Ensembl
    17. negative regulation of neuron death Source: Ensembl
    18. neuron projection development Source: Ensembl
    19. neuropeptide signaling pathway Source: Ensembl
    20. pancreatic juice secretion Source: Ensembl
    21. positive regulation of behavioral fear response Source: Ensembl
    22. positive regulation of calcium ion import Source: Ensembl
    23. positive regulation of cAMP biosynthetic process Source: Ensembl
    24. positive regulation of cardiac muscle contraction Source: Ensembl
    25. positive regulation of cell growth Source: Ensembl
    26. positive regulation of collagen biosynthetic process Source: Ensembl
    27. positive regulation of corticotropin secretion Source: Ensembl
    28. positive regulation of DNA replication Source: Ensembl
    29. positive regulation of gene expression Source: Ensembl
    30. positive regulation of interleukin-6 production Source: Ensembl
    31. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    32. positive regulation of translation Source: Ensembl
    33. positive regulation of vascular permeability Source: Ensembl
    34. positive regulation of vasodilation Source: Ensembl
    35. regulation of synaptic transmission, glutamatergic Source: Ensembl
    36. response to estradiol Source: Ensembl
    37. response to glucocorticoid Source: Ensembl
    38. response to oxidative stress Source: Ensembl
    39. response to pain Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urocortin
    Gene namesi
    Name:Ucn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1276123. Ucn.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. dendrite Source: Ensembl
    3. extracellular region Source: UniProtKB-SubCell
    4. perikaryon Source: Ensembl
    5. varicosity Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 8055By similarityPRO_0000006235Add
    BLAST
    Peptidei81 – 12040UrocortinPRO_0000006236Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei120 – 1201Valine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiP81615.

    Expressioni

    Gene expression databases

    BgeeiP81615.
    CleanExiMM_UCN.
    GenevestigatoriP81615.

    Interactioni

    Subunit structurei

    Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP81615.
    SMRiP81615. Positions 81-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46022.
    HOGENOMiHOG000121779.
    HOVERGENiHBG036241.
    InParanoidiP81615.
    OMAiLRWSPGA.
    OrthoDBiEOG73JKZD.
    PhylomeDBiP81615.
    TreeFamiTF332956.

    Family and domain databases

    InterProiIPR018446. Corticotropin-releasing_fac_CS.
    IPR000187. Corticotropin-releasing_factor.
    IPR003620. Urocortin_CRF.
    [Graphical view]
    PANTHERiPTHR15035. PTHR15035. 1 hit.
    PfamiPF00473. CRF. 1 hit.
    [Graphical view]
    PRINTSiPR01612. CRFFAMILY.
    SMARTiSM00039. CRF. 1 hit.
    [Graphical view]
    PROSITEiPS00511. CRF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P81615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQRGRATLL VALLLLAQLR PESSQWSPAA AAATGVQDPN LRWSPGVRNQ    50
    GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL 100
    ARTQSQRERA EQNRIIFDSV GK 122
    Length:122
    Mass (Da):13,558
    Last modified:January 1, 1999 - v1
    Checksum:iD2969756F36F5DEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038632 Genomic DNA. Translation: AAC24202.1.
    CCDSiCCDS19174.1.
    RefSeqiNP_067265.1. NM_021290.2.
    UniGeneiMm.377116.

    Genome annotation databases

    EnsembliENSMUST00000043475; ENSMUSP00000035321; ENSMUSG00000038676.
    GeneIDi22226.
    KEGGimmu:22226.
    UCSCiuc008wxe.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038632 Genomic DNA. Translation: AAC24202.1 .
    CCDSi CCDS19174.1.
    RefSeqi NP_067265.1. NM_021290.2.
    UniGenei Mm.377116.

    3D structure databases

    ProteinModelPortali P81615.
    SMRi P81615. Positions 81-120.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P81615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043475 ; ENSMUSP00000035321 ; ENSMUSG00000038676 .
    GeneIDi 22226.
    KEGGi mmu:22226.
    UCSCi uc008wxe.1. mouse.

    Organism-specific databases

    CTDi 7349.
    MGIi MGI:1276123. Ucn.

    Phylogenomic databases

    eggNOGi NOG46022.
    HOGENOMi HOG000121779.
    HOVERGENi HBG036241.
    InParanoidi P81615.
    OMAi LRWSPGA.
    OrthoDBi EOG73JKZD.
    PhylomeDBi P81615.
    TreeFami TF332956.

    Miscellaneous databases

    NextBioi 302255.
    PROi P81615.
    SOURCEi Search...

    Gene expression databases

    Bgeei P81615.
    CleanExi MM_UCN.
    Genevestigatori P81615.

    Family and domain databases

    InterProi IPR018446. Corticotropin-releasing_fac_CS.
    IPR000187. Corticotropin-releasing_factor.
    IPR003620. Urocortin_CRF.
    [Graphical view ]
    PANTHERi PTHR15035. PTHR15035. 1 hit.
    Pfami PF00473. CRF. 1 hit.
    [Graphical view ]
    PRINTSi PR01612. CRFFAMILY.
    SMARTi SM00039. CRF. 1 hit.
    [Graphical view ]
    PROSITEi PS00511. CRF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structures of the mouse and human urocortin genes (Ucn and UCN)."
      Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
      Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiUCN1_MOUSE
    AccessioniPrimary (citable) accession number: P81615
    Secondary accession number(s): O88390
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1999
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3