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P81605

- DCD_HUMAN

UniProt

P81605 - DCD_HUMAN

Protein

Dermcidin

Gene

DCD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.
    Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Manganese. Required for survival-promoting peptide.

    GO - Molecular functioni

    1. peptidase activity Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. defense response to fungus Source: UniProtKB-KW
    3. killing of cells of other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Fungicide, Hydrolase, Protease

    Keywords - Ligandi

    Manganese

    Protein family/group databases

    TCDBi1.C.108.1.1. the pore-forming dermcidin (dermcidin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dermcidin (EC:3.4.-.-)
    Alternative name(s):
    Preproteolysin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:DCD
    Synonyms:AIDD, DSEP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14669. DCD.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19192 PublicationsAdd
    BLAST
    Chaini20 – 11091DermcidinPRO_0000021081Add
    BLAST
    Peptidei20 – 4930Survival-promoting peptidePRO_0000021082Add
    BLAST
    Propeptidei50 – 62131 PublicationPRO_0000021083Add
    BLAST
    Peptidei63 – 10947DCD-1PRO_0000021084Add
    BLAST
    Propeptidei110 – 1101PRO_0000408312

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei68 – 681N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP81605.
    PaxDbiP81605.
    PeptideAtlasiP81605.
    PRIDEiP81605.

    2D gel databases

    UCD-2DPAGEP81605.

    PTM databases

    PhosphoSiteiP81605.

    Miscellaneous databases

    PMAP-CutDBP81605.

    Expressioni

    Tissue specificityi

    Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

    Gene expression databases

    BgeeiP81605.
    CleanExiHS_DCD.
    GenevestigatoriP81605.

    Interactioni

    Protein-protein interaction databases

    BioGridi125564. 28 interactions.
    IntActiP81605. 10 interactions.
    MINTiMINT-5000551.
    STRINGi9606.ENSP00000293371.

    Structurei

    Secondary structure

    1
    110
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi67 – 10741

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KSGNMR-A63-110[»]
    2YMKX-ray2.49A/B/C63-110[»]
    ProteinModelPortaliP81605.
    SMRiP81605. Positions 63-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP81605.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG75451.
    HOGENOMiHOG000280682.
    HOVERGENiHBG018946.
    InParanoidiP81605.
    OMAiSEECAGY.
    OrthoDBiEOG7J9VSJ.
    PhylomeDBiP81605.
    TreeFamiTF340896.

    Family and domain databases

    InterProiIPR028130. Dermcidin.
    [Graphical view]
    PfamiPF15291. Dermcidin. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P81605-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG    50
    LARQAPKPRK QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH 100
    DVKDVLDSVL 110
    Length:110
    Mass (Da):11,284
    Last modified:January 23, 2002 - v2
    Checksum:i23666FBD20019465
    GO
    Isoform 2 (identifier: P81605-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-110: AVHDVKDVLDSVL → GEERLVFGAPVNLTSIPLTSVSRP

    Show »
    Length:121
    Mass (Da):12,414
    Checksum:i1ED0E009B72ADA55
    GO
    Isoform 3 (identifier: P81605-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-77: PCHEASAAQK...KGLDGAKKAV → HKQMDCLQLQ...AKPPHTRGLV
         78-110: Missing.

    Show »
    Length:77
    Mass (Da):8,295
    Checksum:i60CB579573DA59AA
    GO

    Mass spectrometryi

    Molecular mass is 4702.57 Da from positions 63 - 109. Determined by ESI. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 7745PCHEA…AKKAV → HKQMDCLQLQKPPSETAKFL SSSTNLPRREKLVPSAKPPH TRGLV in isoform 3. 1 PublicationVSP_043765Add
    BLAST
    Alternative sequencei78 – 11033Missing in isoform 3. 1 PublicationVSP_043766Add
    BLAST
    Alternative sequencei98 – 11013AVHDV…LDSVL → GEERLVFGAPVNLTSIPLTS VSRP in isoform 2. CuratedVSP_043767Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144011 mRNA. Translation: AAL18349.1.
    AY044239 Genomic DNA. Translation: AAK94785.1.
    AF418981 Genomic DNA. Translation: AAL25801.1.
    AY590150 mRNA. Translation: AAS99907.1.
    EF503687 mRNA. Translation: ABQ53649.1.
    EF503688 mRNA. Translation: ABQ53650.1.
    EF503689 mRNA. Translation: ABQ53651.1.
    AC079310 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96794.1.
    BC062682 mRNA. Translation: AAH62682.1.
    BC069108 mRNA. Translation: AAH69108.1.
    CCDSiCCDS8884.1. [P81605-1]
    RefSeqiNP_444513.1. NM_053283.2. [P81605-1]
    XP_005268684.1. XM_005268627.1. [P81605-2]
    UniGeneiHs.350570.

    Genome annotation databases

    EnsembliENST00000293371; ENSP00000293371; ENSG00000161634. [P81605-1]
    ENST00000456047; ENSP00000406773; ENSG00000161634. [P81605-2]
    ENST00000546807; ENSP00000450415; ENSG00000161634. [P81605-3]
    GeneIDi117159.
    KEGGihsa:117159.
    UCSCiuc001sgj.3. human. [P81605-1]
    uc009znt.3. human. [P81605-2]

    Polymorphism databases

    DMDMi20141302.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Smart sweat - Issue 18 of January 2002

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144011 mRNA. Translation: AAL18349.1 .
    AY044239 Genomic DNA. Translation: AAK94785.1 .
    AF418981 Genomic DNA. Translation: AAL25801.1 .
    AY590150 mRNA. Translation: AAS99907.1 .
    EF503687 mRNA. Translation: ABQ53649.1 .
    EF503688 mRNA. Translation: ABQ53650.1 .
    EF503689 mRNA. Translation: ABQ53651.1 .
    AC079310 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96794.1 .
    BC062682 mRNA. Translation: AAH62682.1 .
    BC069108 mRNA. Translation: AAH69108.1 .
    CCDSi CCDS8884.1. [P81605-1 ]
    RefSeqi NP_444513.1. NM_053283.2. [P81605-1 ]
    XP_005268684.1. XM_005268627.1. [P81605-2 ]
    UniGenei Hs.350570.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KSG NMR - A 63-110 [» ]
    2YMK X-ray 2.49 A/B/C 63-110 [» ]
    ProteinModelPortali P81605.
    SMRi P81605. Positions 63-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125564. 28 interactions.
    IntActi P81605. 10 interactions.
    MINTi MINT-5000551.
    STRINGi 9606.ENSP00000293371.

    Protein family/group databases

    TCDBi 1.C.108.1.1. the pore-forming dermcidin (dermcidin) family.

    PTM databases

    PhosphoSitei P81605.

    Polymorphism databases

    DMDMi 20141302.

    2D gel databases

    UCD-2DPAGE P81605.

    Proteomic databases

    MaxQBi P81605.
    PaxDbi P81605.
    PeptideAtlasi P81605.
    PRIDEi P81605.

    Protocols and materials databases

    DNASUi 117159.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293371 ; ENSP00000293371 ; ENSG00000161634 . [P81605-1 ]
    ENST00000456047 ; ENSP00000406773 ; ENSG00000161634 . [P81605-2 ]
    ENST00000546807 ; ENSP00000450415 ; ENSG00000161634 . [P81605-3 ]
    GeneIDi 117159.
    KEGGi hsa:117159.
    UCSCi uc001sgj.3. human. [P81605-1 ]
    uc009znt.3. human. [P81605-2 ]

    Organism-specific databases

    CTDi 117159.
    GeneCardsi GC12M055038.
    HGNCi HGNC:14669. DCD.
    MIMi 606634. gene.
    neXtProti NX_P81605.
    PharmGKBi PA27171.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG75451.
    HOGENOMi HOG000280682.
    HOVERGENi HBG018946.
    InParanoidi P81605.
    OMAi SEECAGY.
    OrthoDBi EOG7J9VSJ.
    PhylomeDBi P81605.
    TreeFami TF340896.

    Miscellaneous databases

    EvolutionaryTracei P81605.
    GeneWikii Dermcidin.
    GenomeRNAii 117159.
    NextBioi 80125.
    PMAP-CutDB P81605.
    PROi P81605.
    SOURCEi Search...

    Gene expression databases

    Bgeei P81605.
    CleanExi HS_DCD.
    Genevestigatori P81605.

    Family and domain databases

    InterProi IPR028130. Dermcidin.
    [Graphical view ]
    Pfami PF15291. Dermcidin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 63-109, MASS SPECTROMETRY.
      Tissue: Melanoma.
    2. "Overexpression of new survival/evasion peptide (DSEP) attenuates retinoic acid responses and protects cells."
      Cunningham T.J., Jing H., Akerblom I., Morgan R., Fisher T.S., Neveu M.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genomic structure and chromosomal mapping of human preproteolysin gene."
      Tang X.D., Daggett H., Hoshi T.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Structural and functional homologies of human proteolysis inducing factor."
      Lowrie A.G., Wigmore S.J., Deans D.A.C., Fearon K.C.H., Waddell I., Ross J.A.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity."
      Lee Motoyama J.P., Kim-Motoyama H., Kim P., Nakagama H., Miyagawa K., Suzuki K.
      Biochem. Biophys. Res. Commun. 357:828-833(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 3), PROTEOLYTIC FUNCTION, ALTERNATIVE SPLICING.
      Tissue: Placenta.
    6. "The finished DNA sequence of human chromosome 12."
      Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    9. "Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin."
      Cunningham T.J., Hodge L., Speicher D., Reim D., Tyler-Polsz C., Levitt P., Eagleson K., Kennedy S., Wang Y.
      J. Neurosci. 18:7047-7060(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-49.
      Tissue: Retinoblastoma.
    10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.
    11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles."
      Jung H.H., Yang S.T., Sim J.Y., Lee S., Lee J.Y., Kim H.H., Shin S.Y., Kim J.I.
      BMB Rep. 43:362-368(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 63-110.

    Entry informationi

    Entry nameiDCD_HUMAN
    AccessioniPrimary (citable) accession number: P81605
    Secondary accession number(s): A5JHP2
    , A5JHP3, P58461, Q53YJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3