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Protein

Dermcidin

Gene

DCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).1 Publication
Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Cofactori

Mn2+Note: Mn2+ is required for survival-promoting peptide.

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response to bacterium Source: UniProtKB-KW
  • defense response to fungus Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide, Hydrolase, Protease
LigandManganese

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Protein family/group databases

TCDBi1.C.108.1.1 the pore-forming dermcidin (dermcidin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Dermcidin (EC:3.4.-.-)
Alternative name(s):
Preproteolysin
Cleaved into the following 2 chains:
Gene namesi
Name:DCD
Synonyms:AIDD, DSEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000161634.11
HGNCiHGNC:14669 DCD
MIMi606634 gene
neXtProtiNX_P81605

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi117159
OpenTargetsiENSG00000161634
PharmGKBiPA27171

Polymorphism and mutation databases

BioMutaiDCD
DMDMi20141302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 193 PublicationsAdd BLAST19
ChainiPRO_000002108120 – 110DermcidinAdd BLAST91
PeptideiPRO_000002108220 – 49Survival-promoting peptideAdd BLAST30
PropeptideiPRO_000002108350 – 621 PublicationAdd BLAST13
PeptideiPRO_000002108463 – 109DCD-1Add BLAST47
PropeptideiPRO_00004083121101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP81605
PaxDbiP81605
PeptideAtlasiP81605
PRIDEiP81605
TopDownProteomicsiP81605-1 [P81605-1]

2D gel databases

UCD-2DPAGEiP81605

PTM databases

iPTMnetiP81605
PhosphoSitePlusiP81605

Miscellaneous databases

PMAP-CutDBiP81605

Expressioni

Tissue specificityi

Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

Gene expression databases

BgeeiENSG00000161634
CleanExiHS_DCD
GenevisibleiP81605 HS

Organism-specific databases

HPAiHPA063967

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-395625,EBI-743771

Protein-protein interaction databases

BioGridi12556445 interactors.
IntActiP81605 26 interactors.

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi67 – 107Combined sources41

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSGNMR-A63-110[»]
2NDKNMR-A63-110[»]
2YMKX-ray2.49A/B/C63-110[»]
ProteinModelPortaliP81605
SMRiP81605
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81605

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KF1A Eukaryota
ENOG411167G LUCA
GeneTreeiENSGT00390000016873
HOGENOMiHOG000280682
HOVERGENiHBG018946
InParanoidiP81605
OMAiPCHEASA
OrthoDBiEOG091G0W55
PhylomeDBiP81605
TreeFamiTF340896

Family and domain databases

InterProiView protein in InterPro
IPR028130 Dermcidin
PANTHERiPTHR40711:SF1 PTHR40711:SF1, 1 hit
PfamiView protein in Pfam
PF15291 Dermcidin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P81605-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG
60 70 80 90 100
LARQAPKPRK QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH
110
DVKDVLDSVL
Length:110
Mass (Da):11,284
Last modified:January 23, 2002 - v2
Checksum:i23666FBD20019465
GO
Isoform 2 (identifier: P81605-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-110: AVHDVKDVLDSVL → GEERLVFGAPVNLTSIPLTSVSRP

Show »
Length:121
Mass (Da):12,414
Checksum:i1ED0E009B72ADA55
GO
Isoform 3 (identifier: P81605-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-77: PCHEASAAQK...KGLDGAKKAV → HKQMDCLQLQ...AKPPHTRGLV
     78-110: Missing.

Show »
Length:77
Mass (Da):8,295
Checksum:i60CB579573DA59AA
GO

Mass spectrometryi

Molecular mass is 4702.57 Da from positions 63 - 109. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04376533 – 77PCHEA…AKKAV → HKQMDCLQLQKPPSETAKFL SSSTNLPRREKLVPSAKPPH TRGLV in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_04376678 – 110Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_04376798 – 110AVHDV…LDSVL → GEERLVFGAPVNLTSIPLTS VSRP in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144011 mRNA Translation: AAL18349.1
AY044239 Genomic DNA Translation: AAK94785.1
AF418981 Genomic DNA Translation: AAL25801.1
AY590150 mRNA Translation: AAS99907.1
EF503687 mRNA Translation: ABQ53649.1
EF503688 mRNA Translation: ABQ53650.1
EF503689 mRNA Translation: ABQ53651.1
AC079310 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96794.1
BC062682 mRNA Translation: AAH62682.1
BC069108 mRNA Translation: AAH69108.1
CCDSiCCDS73478.1 [P81605-2]
CCDS8884.1 [P81605-1]
RefSeqiNP_001287783.1, NM_001300854.1 [P81605-2]
NP_444513.1, NM_053283.3 [P81605-1]
UniGeneiHs.350570

Genome annotation databases

EnsembliENST00000293371; ENSP00000293371; ENSG00000161634 [P81605-1]
ENST00000456047; ENSP00000406773; ENSG00000161634 [P81605-2]
ENST00000546807; ENSP00000450415; ENSG00000161634 [P81605-3]
GeneIDi117159
KEGGihsa:117159
UCSCiuc001sgj.4 human [P81605-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDCD_HUMAN
AccessioniPrimary (citable) accession number: P81605
Secondary accession number(s): A5JHP2
, A5JHP3, P58461, Q53YJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2002
Last modified: April 25, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome