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P81605 (DCD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dermcidin

EC=3.4.-.-
Alternative name(s):
Preproteolysin

Cleaved into the following 2 chains:

  1. Survival-promoting peptide
  2. DCD-1
Gene names
Name:DCD
Synonyms:AIDD, DSEP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length110 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. Ref.5

Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. Ref.5

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor

Manganese. Required for survival-promoting peptide.

Subcellular location

Secreted.

Tissue specificity

Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

Mass spectrometry

Molecular mass is 4702.57 Da from positions 63 - 109. Determined by ESI. Ref.1

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P81605-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P81605-2)

The sequence of this isoform differs from the canonical sequence as follows:
     98-110: AVHDVKDVLDSVL → GEERLVFGAPVNLTSIPLTSVSRP
Isoform 3 (identifier: P81605-3)

The sequence of this isoform differs from the canonical sequence as follows:
     33-77: PCHEASAAQK...KGLDGAKKAV → HKQMDCLQLQ...AKPPHTRGLV
     78-110: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.9 Ref.10
Chain20 – 11091Dermcidin
PRO_0000021081
Peptide20 – 4930Survival-promoting peptide Ref.9
PRO_0000021082
Propeptide50 – 6213
PRO_0000021083
Peptide63 – 10947DCD-1 Ref.1
PRO_0000021084
Propeptide1101
PRO_0000408312

Amino acid modifications

Modified residue681N6-acetyllysine Ref.11

Natural variations

Alternative sequence33 – 7745PCHEA…AKKAV → HKQMDCLQLQKPPSETAKFL SSSTNLPRREKLVPSAKPPH TRGLV in isoform 3.
VSP_043765
Alternative sequence78 – 11033Missing in isoform 3.
VSP_043766
Alternative sequence98 – 11013AVHDV…LDSVL → GEERLVFGAPVNLTSIPLTS VSRP in isoform 2.
VSP_043767

Secondary structure

... 110
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 23666FBD20019465

FASTA11011,284
        10         20         30         40         50         60 
MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG LARQAPKPRK 

        70         80         90        100        110 
QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH DVKDVLDSVL 

« Hide

Isoform 2 [UniParc].

Checksum: 1ED0E009B72ADA55
Show »

FASTA12112,414
Isoform 3 [UniParc].

Checksum: 60CB579573DA59AA
Show »

FASTA778,295

References

« Hide 'large scale' references
[1]"Dermcidin: a novel human antibiotic peptide secreted by sweat glands."
Schittek B., Hipfel R., Sauer B., Bauer J., Kalbacher H., Stevanovic S., Schirle M., Schroeder K., Blin N., Meier F., Rassner G., Garbe C.
Nat. Immunol. 2:1133-1137(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 63-109, MASS SPECTROMETRY.
Tissue: Melanoma.
[2]"Overexpression of new survival/evasion peptide (DSEP) attenuates retinoic acid responses and protects cells."
Cunningham T.J., Jing H., Akerblom I., Morgan R., Fisher T.S., Neveu M.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genomic structure and chromosomal mapping of human preproteolysin gene."
Tang X.D., Daggett H., Hoshi T.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Structural and functional homologies of human proteolysis inducing factor."
Lowrie A.G., Wigmore S.J., Deans D.A.C., Fearon K.C.H., Waddell I., Ross J.A.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity."
Lee Motoyama J.P., Kim-Motoyama H., Kim P., Nakagama H., Miyagawa K., Suzuki K.
Biochem. Biophys. Res. Commun. 357:828-833(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 3), PROTEOLYTIC FUNCTION, ALTERNATIVE SPLICING.
Tissue: Placenta.
[6]"The finished DNA sequence of human chromosome 12."
Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[9]"Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin."
Cunningham T.J., Hodge L., Speicher D., Reim D., Tyler-Polsz C., Levitt P., Eagleson K., Kennedy S., Wang Y.
J. Neurosci. 18:7047-7060(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-49.
Tissue: Retinoblastoma.
[10]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
[11]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles."
Jung H.H., Yang S.T., Sim J.Y., Lee S., Lee J.Y., Kim H.H., Shin S.Y., Kim J.I.
BMB Rep. 43:362-368(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 63-110.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Smart sweat - Issue 18 of January 2002

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF144011 mRNA. Translation: AAL18349.1.
AY044239 Genomic DNA. Translation: AAK94785.1.
AF418981 Genomic DNA. Translation: AAL25801.1.
AY590150 mRNA. Translation: AAS99907.1.
EF503687 mRNA. Translation: ABQ53649.1.
EF503688 mRNA. Translation: ABQ53650.1.
EF503689 mRNA. Translation: ABQ53651.1.
AC079310 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96794.1.
BC062682 mRNA. Translation: AAH62682.1.
BC069108 mRNA. Translation: AAH69108.1.
CCDSCCDS8884.1. [P81605-1]
RefSeqNP_444513.1. NM_053283.2. [P81605-1]
XP_005268684.1. XM_005268627.1. [P81605-2]
UniGeneHs.350570.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KSGNMR-A63-110[»]
2YMKX-ray2.49A/B/C63-110[»]
ProteinModelPortalP81605.
SMRP81605. Positions 63-110.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125564. 54 interactions.
IntActP81605. 10 interactions.
MINTMINT-5000551.
STRING9606.ENSP00000293371.

Protein family/group databases

TCDB1.C.108.1.1. the pore-forming dermcidin (dermcidin) family.

PTM databases

PhosphoSiteP81605.

Polymorphism databases

DMDM20141302.

2D gel databases

UCD-2DPAGEP81605.

Proteomic databases

MaxQBP81605.
PaxDbP81605.
PeptideAtlasP81605.
PRIDEP81605.

Protocols and materials databases

DNASU117159.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293371; ENSP00000293371; ENSG00000161634. [P81605-1]
ENST00000456047; ENSP00000406773; ENSG00000161634. [P81605-2]
ENST00000546807; ENSP00000450415; ENSG00000161634. [P81605-3]
GeneID117159.
KEGGhsa:117159.
UCSCuc001sgj.3. human. [P81605-1]
uc009znt.3. human. [P81605-2]

Organism-specific databases

CTD117159.
GeneCardsGC12M055038.
HGNCHGNC:14669. DCD.
MIM606634. gene.
neXtProtNX_P81605.
PharmGKBPA27171.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75451.
HOGENOMHOG000280682.
HOVERGENHBG018946.
InParanoidP81605.
OMASEECAGY.
OrthoDBEOG7J9VSJ.
PhylomeDBP81605.
TreeFamTF340896.

Gene expression databases

BgeeP81605.
CleanExHS_DCD.
GenevestigatorP81605.

Family and domain databases

InterProIPR028130. Dermcidin.
[Graphical view]
PfamPF15291. Dermcidin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP81605.
GeneWikiDermcidin.
GenomeRNAi117159.
NextBio80125.
PMAP-CutDBP81605.
PROP81605.
SOURCESearch...

Entry information

Entry nameDCD_HUMAN
AccessionPrimary (citable) accession number: P81605
Secondary accession number(s): A5JHP2 expand/collapse secondary AC list , A5JHP3, P58461, Q53YJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM