Reviewed, UniProtKB/Swiss-Prot P81605 (DCD_HUMAN)

Names and origin

Protein names

Recommended name:
    Dermcidin
Alternative name(s):
    Preproteolysin
Cleaved into the following 2 chains:
    1- Recommended name:
            Survival-promoting peptide
    2- Recommended name:
            DCD-1

Gene names

Name:	DCD
Synonyms:	AIDD, DSEP

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Cofactor	Manganese. Required for survival-promoting peptide.
Subcellular location	Secreted.
Tissue specificity	Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
Mass spectrometry	Molecular mass is 4702.57 Da from positions 63 - 109. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Manganese
Molecular function	Antibiotic Antimicrobial Fungicide
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW killing of cells of another organism Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Ref.5 Inferred from direct assay. Source: UniProtKB
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CD2BP2	O95400	1	EBI-395625,EBI-768015
CDC42BPB	Q9Y5S2	1	EBI-395625,EBI-1043430
EIF2B1	Q14232	1	EBI-395625,EBI-491065
FAM107A	O95990	1	EBI-395625,EBI-743396
MDM2	Q00987	1	EBI-395625,EBI-389668
RAD51L3	O75771	1	EBI-395625,EBI-1055693
VDAC1	P21796	1	EBI-395625,EBI-354158

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.5 Ref.6
	Chain	20 – 110	91	Dermcidin		PRO_0000021081
	Peptide	20 – 49	30	Survival-promoting peptide Ref.5		PRO_0000021082
	Propeptide	50 – 62	13			PRO_0000021083
	Peptide	63 – 109	47	DCD-1 Ref.1		PRO_0000021084
Amino acid modifications
	Modified residue	68	1	N6-acetyllysine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P81605-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 23666FBD20019465	FASTA	110	11,284
	10 20 30 40 50 60 MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG LARQAPKPRK 70 80 90 100 110 QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH DVKDVLDSVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dermcidin: a novel human antibiotic peptide secreted by sweat glands." Schittek B., Hipfel R., Sauer B., Bauer J., Kalbacher H., Stevanovic S., Schirle M., Schroeder K., Blin N., Meier F., Rassner G., Garbe C. Nat. Immunol. 2:1133-1137(2001) [PubMed: 11694882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 63-109, MASS SPECTROMETRY. Tissue: Melanoma.
[2]	"Overexpression of new survival/evasion peptide (DSEP) attenuates retinoic acid responses and protects cells." Cunningham T.J., Jing H., Akerblom I., Morgan R., Fisher T.S., Neveu M. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genomic structure and chromosomal mapping of human preproteolysin gene." Tang X.D., Daggett H., Hoshi T. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin." Cunningham T.J., Hodge L., Speicher D., Reim D., Tyler-Polsz C., Levitt P., Eagleson K., Kennedy S., Wang Y. J. Neurosci. 18:7047-7060(1998) [PubMed: 9736629] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-49. Tissue: Retinoblastoma.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Smart sweat - Issue 18 of January 2002

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF144011 mRNA. Translation: AAL18349.1. AY044239 Genomic DNA. Translation: AAK94785.1. AF418981 Genomic DNA. Translation: AAL25801.1. BC062682 mRNA. Translation: AAH62682.1. BC069108 mRNA. Translation: AAH69108.1.
IPI	IPI00027547.
RefSeq	NP_444513.1.
UniGene	Hs.350570
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P81605. 17 interactions.
STRING	P81605.
PTM databases
PhosphoSite	P81605.
Proteomic databases
PeptideAtlas	P81605.
PRIDE	P81605.
Genome annotation databases
Ensembl	ENST00000293371; ENSP00000293371; ENSG00000161634; Homo sapiens. [Genome view]
GeneID	117159.
KEGG	hsa:117159.
UCSC	uc001sgj.1. human.
Organism-specific databases
CTD	117159.
GeneCards	GC12M053324.
H-InvDB	HIX0036710.
HGNC	HGNC:14669. DCD.
MIM	606634. gene.
PharmGKB	PA27171.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21190.
HOVERGEN	P81605.
InParanoid	P81605.
PhylomeDB	P81605.
Gene expression databases
ArrayExpress	P81605.
Bgee	P81605.
CleanEx	HS_DCD.
Genevestigator	P81605.
GermOnline	ENSG00000161634. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	80125.
PMAP-CutDB	P81605.
SOURCE	Search...

Entry information

Entry name

DCD_HUMAN

Accession

Primary (citable) accession number: P81605
Secondary accession number(s): P58461

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2002
Last modified:	January 19, 2010
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.