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Protein

Alcohol dehydrogenase class-3 chain L

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Sitei116Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi175Zinc 1; catalytic1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 chain L (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III chain L
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607641 – 375Alcohol dehydrogenase class-3 chain LAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine2 Publications1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP81601

PTM databases

iPTMnetiP81601

Interactioni

Subunit structurei

Homodimer or heterodimer with H chain.

Structurei

3D structure databases

ProteinModelPortaliP81601
SMRiP81601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P81601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATVGKTIRCR AAVAWEAGKP LSMEEVEVAP PQAGEVRIKI VATGICHTDA
60 70 80 90 100
YTLSGSDPEG VFPSVLGHEG AGIVESVGEG VTKFKSGDAV IPLYVPQCGE
110 120 130 140 150
CKFCKNPKTN LCQKIRLTQG KGLMPNGTSR FSCNGQVLFH FMGSSTFSEY
160 170 180 190 200
TVVAEISLAK VHEKAPLDKV CLLGCAISTG YGAALNTAKV EAGSTCAVFG
210 220 230 240 250
LGALGLAVIM GCQAAGASRI IAIDVNPDKF RIAKEFGATD LVNPKDHSKP
260 270 280 290 300
VEQVLVEMTD GGVDYSFECV GNIAVMRAAL EACHKGWGTS VIIGVAAAGQ
310 320 330 340 350
EISTRPFQLV TGRTWKGTAF GGYKSVESVP KLVEEYMNKK VKVDEFVTHT
360 370
LPFEKIHEGF DLMGAGKSIR TVLNY
Length:375
Mass (Da):39,703
Last modified:July 15, 1999 - v1
Checksum:iAEFE01C99243DBC9
GO

Similar proteinsi

Entry informationi

Entry nameiADHL_GADMO
AccessioniPrimary (citable) accession number: P81601
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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