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Protein

Alcohol dehydrogenase class-3 chain H

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Sitei116Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi175Zinc 1; catalytic1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 chain H (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III chain H
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607631 – 375Alcohol dehydrogenase class-3 chain HAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine2 Publications1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer or heterodimer with L chain.

Structurei

3D structure databases

ProteinModelPortaliP81600.
SMRiP81600.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOVERGENiHBG000195.

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P81600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATAGQVIKCK AAVAWEAGKP LSLEEVEVAP PRAGEVRIKV VATGVCHTDA
60 70 80 90 100
YTLSGSDPEG AFPVILGHEG AGLVESVGEG VTKFKAGDTV IPLYVPQCGE
110 120 130 140 150
CKFCKNPKTN LCQKIRVTQG RGLMPDNTSR FTCKGKQLFH FMGTSTFSEY
160 170 180 190 200
TVVADISLAN VDPKAPLDKV CLLGCGISTG YGAALNTAKV EPGSTCAVFG
210 220 230 240 250
LGAVGLAAIM GCKVAGATRI IGVDINPEKF GKAAEFGATE CLNPKDHARP
260 270 280 290 300
VQEVLVEMTD GGVDYSFECI GNVEIMRSAL EACHKGWGES VIIGVAGAGQ
310 320 330 340 350
EIATRPFQLV TGRVWKATAF GGWKSVESVP KLVEDYMNKK LKVDEFVTHT
360 370
LPFDSINEGF DLMHAGKSIR CVLTF
Length:375
Mass (Da):39,669
Last modified:July 15, 1999 - v1
Checksum:i0B9760AB77329FE3
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADHH_GADMO
AccessioniPrimary (citable) accession number: P81600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families