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P81563

- MMP1_RAT

UniProt

P81563 - MMP1_RAT

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Protein

Interstitial collagenase

Gene

Mmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. May play a role in the deterioration of the heart wall extracellular matrix proteins during the onset of dilated cardiomyopathy.

Catalytic activityi

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 4 Ca(2+) ions per subunit.By similarity
  • Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Enzyme regulationi

Can be activated without removal of the activation peptide.

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Interstitial collagenase (EC:3.4.24.7)
Alternative name(s):
Fibroblast collagenase
Matrix metalloproteinase-1
Short name:
MMP-1
Myocardial collagenase
Gene namesi
Name:Mmp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›15›15Interstitial collagenasePRO_0000078182Add
BLAST

Post-translational modificationi

The N-terminus is blocked.
Tyrosine phosphorylated in platelets by PKDCC/VLK.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriP81563.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Sequencei

Sequence statusi: Fragment.

P81563-1 [UniParc]FASTAAdd to Basket

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        10 
DTLKSEKNAD FKDLY
Length:15
Mass (Da):1,787
Last modified:May 30, 2000 - v1
Checksum:i15A57D24C0F6FD80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei15 – 151

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Genevestigatori P81563.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Myocardial collagenase: purification and structural characterization."
    Tyagi S.C., Cleutjens J.P.M.
    Can. J. Cardiol. 12:165-171(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Heart.

Entry informationi

Entry nameiMMP1_RAT
AccessioniPrimary (citable) accession number: P81563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3