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P81563

- MMP1_RAT

UniProt

P81563 - MMP1_RAT

Protein

Interstitial collagenase

Gene

Mmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. May play a role in the deterioration of the heart wall extracellular matrix proteins during the onset of dilated cardiomyopathy.

    Catalytic activityi

    Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.

    Cofactori

    Binds 4 calcium ions per subunit.By similarity
    Binds 2 zinc ions per subunit.By similarity

    Enzyme regulationi

    Can be activated without removal of the activation peptide.

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Collagen degradation

    Keywords - Ligandi

    Calcium, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interstitial collagenase (EC:3.4.24.7)
    Alternative name(s):
    Fibroblast collagenase
    Matrix metalloproteinase-1
    Short name:
    MMP-1
    Myocardial collagenase
    Gene namesi
    Name:Mmp1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›15›15Interstitial collagenasePRO_0000078182Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Expressioni

    Gene expression databases

    GenevestigatoriP81563.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M10A family.Curated

    Sequencei

    Sequence statusi: Fragment.

    P81563-1 [UniParc]FASTAAdd to Basket

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    DTLKSEKNAD FKDLY                                         15
    Length:15
    Mass (Da):1,787
    Last modified:May 30, 2000 - v1
    Checksum:i15A57D24C0F6FD80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei15 – 151

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    Genevestigatori P81563.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Myocardial collagenase: purification and structural characterization."
      Tyagi S.C., Cleutjens J.P.M.
      Can. J. Cardiol. 12:165-171(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Heart.

    Entry informationi

    Entry nameiMMP1_RAT
    AccessioniPrimary (citable) accession number: P81563
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3