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P81563 - MMP1_RAT
- Names & Taxonomy
- Subcellular locationSubcell. location
- Pathology & BiotechPathol./Biotech
- PTM / Processing
- Family & Domains
- Entry information
- BLAST>sp|P81563|MMP1_RAT Interstitial collagenase (Fragment) OS=Rattus norvegicus GN=Mmp1 PE=1 SV=1 DTLKSEKNADFKDLY
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Select a section on the left to see content.Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. May play a role in the deterioration of the heart wall extracellular matrix proteins during the onset of dilated cardiomyopathy.Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
<p>Provides information relevant to cofactors. A cofactor is any non-protein substance required for an enzyme to be catalytically active. Some cofactors are inorganic, such as metal ions in various oxidation states. Others, such as most vitamins, are organic molecules.</p><p><a href='../manual/cofactor' target='_top'>More...</a></p>CofactoriBinds 4 calcium ions per subunit.By similarityBinds 2 zinc ions per subunit.By similarity
<p>Describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.</p><p><a href='../manual/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationiCan be activated without removal of the activation peptide.
- metallopeptidase activity Source: UniProtKB-KW
- collagen catabolic process Source: UniProtKB-KW
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='../help/keywords' target='_top'>More...</a></p>Keywords - Biological processiCollagen degradationRecommended name:Interstitial collagenase (EC:22.214.171.124)Alternative name(s):Fibroblast collagenaseMatrix metalloproteinase-1Short name:MMP-1Myocardial collagenaseName:Mmp1
Rattus norvegicus (Rat) 10116 [NCBI] cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus UP000002494: Unplaced
- proteinaceous extracellular matrix Source: UniProtKB-SubCell
Feature key Position(s) Length Description Graphical view Feature identifier Actions ‹1 – ›15 ›15 Interstitial collagenase PRO_0000078182 Add
<p>Describes post-translational modifications (PTMs). This subsection complements the information provided at the sequence level or describes modifications for which position-specific data is not yet available.</p><p><a href='../manual/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationiThe N-terminus is blocked.
<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni
Gene expression databases
Genevestigator<br/><a href='/database/142'>More..</a>Genevestigatori P81563.Belongs to the peptidase M10A family.Curated
<p>Indicates if the canonical sequence displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.Length:15Mass (Da):1,787Last modified:May 30, 2000 - v1<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15A57D24C0F6FD80
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.</p><p><a href='../manual/non_ter' target='_top'>More...</a></p>Non-terminal residuei 1 – 1 1 <p>Is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.</p><p><a href='../manual/non_ter' target='_top'>More...</a></p>Non-terminal residuei 15 – 15 1
3D structure databases
Database of comparative protein structure models<br/><a href='/database/63'>More..</a> ModBasei Search... Search...
Protocols and materials databases
Structural Biology Knowledgebase Search...
Gene expression databases
Genevestigator<br/><a href='/database/142'>More..</a> Genevestigatori P81563.
Family and domain databases
Search... MMP1_RAT P81563Primary (citable) accession number: P81563 Integrated into UniProtKB/Swiss-Prot: May 30, 2000 Last sequence update: May 30, 2000 Last modified: October 1, 2014 This is version 54 of the entry and version 1 of the sequence. [Complete history] Reviewed (UniProtKB/Swiss-Prot) Annotation program Chordata Protein Annotation Program
- Peptidase familiesClassification of peptidase families and list of entries
- SIMILARITY commentsIndex of protein domains and families
External DataDasty 3