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Protein

Estrogen receptor

Gene

esr1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi180 – 245Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri180 – 200NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri216 – 240NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864840 esr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536391 – 586Estrogen receptorAdd BLAST586

Proteomic databases

PRIDEiP81559

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP81559
SMRiP81559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 539NR LBDPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 179ModulatingAdd BLAST179
Regioni246 – 302HingeAdd BLAST57

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 200NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri216 – 240NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108344

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P81559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMPLPNKTT GVTFLHQIQS SELETLTRPP LKISLERPLG EMYVENNRTG
60 70 80 90 100
IFNYPEGTTY DFAAAAAPVY SSASLSYAAS SETFGSSSLT GLHTLNNVPP
110 120 130 140 150
SPVVFLAKLP QLSPFIHHHG QQVPYYLESE QGTFAVREAA PPTFYRSSSD
160 170 180 190 200
NRRQSGRERM SSANDKGPPS MESTKETRYC AVCSDYASGY HYGVWSCEGC
210 220 230 240 250
KAFFKRSIQG HNDYMCPATN QCTIDKNRRK SCQACRLRKC YEVGMMKGGI
260 270 280 290 300
RKDRRGGRLL KHKRQKEEQE QKNDVDPSEI RTASIWVNPS VKSMKLSPVL
310 320 330 340 350
SLTAEQLISA LMEAEAPIVY SEHDSTKPLS EASMMTLLTN LADRELVHMI
360 370 380 390 400
NWAKRVPGFV DLTLHDQVHL LECAWLEILM VGLIWRSVEH PGKLSFAPNL
410 420 430 440 450
LLDRNQGRCV EGLVEIFDML VTTATRFRMM RLRGEEFICL KSIILLNSGV
460 470 480 490 500
YTFLSSTLES LEDTDLIHII LDKIIDTLVH FMAKSGLSLQ QQQRRLAQLL
510 520 530 540 550
LILSHIRHMS NKGMEHLYSM KCKNVVPLYD LLLEMLDAHR IHTPKDKTTT
560 570 580
QEEDSRSPPT TTVNGASPCL QPYYTNTEEV SLQSTV
Length:586
Mass (Da):66,081
Last modified:November 1, 1998 - v1
Checksum:i0EDC77EB0D6F08BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20735 mRNA No translation available.
PIRiA40907 QRXLE
UniGeneiXl.21647

Similar proteinsi

Entry informationi

Entry nameiESR1_XENLA
AccessioniPrimary (citable) accession number: P81559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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