Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Estrogen receptor

Gene

esr1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi180 – 245Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri180 – 200NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri216 – 240NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864840. esr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536391 – 586Estrogen receptorAdd BLAST586

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP81559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 179ModulatingAdd BLAST179
Regioni246 – 302HingeAdd BLAST57
Regioni303 – 586Steroid-bindingAdd BLAST284

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 200NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri216 – 240NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMPLPNKTT GVTFLHQIQS SELETLTRPP LKISLERPLG EMYVENNRTG
60 70 80 90 100
IFNYPEGTTY DFAAAAAPVY SSASLSYAAS SETFGSSSLT GLHTLNNVPP
110 120 130 140 150
SPVVFLAKLP QLSPFIHHHG QQVPYYLESE QGTFAVREAA PPTFYRSSSD
160 170 180 190 200
NRRQSGRERM SSANDKGPPS MESTKETRYC AVCSDYASGY HYGVWSCEGC
210 220 230 240 250
KAFFKRSIQG HNDYMCPATN QCTIDKNRRK SCQACRLRKC YEVGMMKGGI
260 270 280 290 300
RKDRRGGRLL KHKRQKEEQE QKNDVDPSEI RTASIWVNPS VKSMKLSPVL
310 320 330 340 350
SLTAEQLISA LMEAEAPIVY SEHDSTKPLS EASMMTLLTN LADRELVHMI
360 370 380 390 400
NWAKRVPGFV DLTLHDQVHL LECAWLEILM VGLIWRSVEH PGKLSFAPNL
410 420 430 440 450
LLDRNQGRCV EGLVEIFDML VTTATRFRMM RLRGEEFICL KSIILLNSGV
460 470 480 490 500
YTFLSSTLES LEDTDLIHII LDKIIDTLVH FMAKSGLSLQ QQQRRLAQLL
510 520 530 540 550
LILSHIRHMS NKGMEHLYSM KCKNVVPLYD LLLEMLDAHR IHTPKDKTTT
560 570 580
QEEDSRSPPT TTVNGASPCL QPYYTNTEEV SLQSTV
Length:586
Mass (Da):66,081
Last modified:November 1, 1998 - v1
Checksum:i0EDC77EB0D6F08BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20735 mRNA. No translation available.
PIRiA40907. QRXLE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20735 mRNA. No translation available.
PIRiA40907. QRXLE.

3D structure databases

ProteinModelPortaliP81559.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

XenbaseiXB-GENE-864840. esr1.

Phylogenomic databases

HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESR1_XENLA
AccessioniPrimary (citable) accession number: P81559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.