P81558 (MBP_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin basic protein
Short name=MBP

Gene names

Name:

MBP

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin.
Post-translational modification	As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1 By similarity.
Sequence similarities	Belongs to the myelin basic protein family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
PTM	Acetylation Citrullination Methylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	myelin sheath Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of myelin sheath Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Myelin basic protein		PRO_0000158993
Amino acid modifications
	Modified residue	1	1	N-acetylalanine
	Modified residue	7	1	Phosphoserine By similarity
	Modified residue	12	1	Phosphoserine By similarity
	Modified residue	25	1	Citrulline By similarity
	Modified residue	31	1	Citrulline By similarity
	Modified residue	35	1	Phosphothreonine By similarity
	Modified residue	39	1	Phosphoserine By similarity
	Modified residue	55	1	Phosphoserine By similarity
	Modified residue	68	1	Phosphotyrosine By similarity
	Modified residue	70	1	Phosphoserine By similarity
	Modified residue	95	1	Phosphothreonine By similarity
	Modified residue	98	1	Phosphothreonine By similarity
	Modified residue	103	1	Deamidated glutamine By similarity
	Modified residue	107	1	Omega-N-methylarginine; alternate Ref.1
	Modified residue	107	1	Symmetric dimethylarginine; alternate Ref.1
	Modified residue	115	1	Phosphoserine By similarity
	Modified residue	122	1	N6-acetyllysine By similarity
	Modified residue	130	1	Citrulline By similarity
	Modified residue	148	1	Deamidated glutamine By similarity
	Modified residue	160	1	Citrulline By similarity
	Modified residue	162	1	Phosphoserine By similarity
	Modified residue	166	1	Phosphoserine; by UHMK1 By similarity
	Modified residue	171	1	Citrulline By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81558 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 287AEDF2F24028D9	FASTA	171	18,487
	10 20 30 40 50 60 ASQKRPSQRH GSKYLASAST MDHARHGFLP RHRDTGIDSL GRFFGADRGA PKRGSGKDGH 70 80 90 100 110 120 HAARTTHYGS LPQKAQHGRP QDENPVVHFF KNIVTPRTPP PSQGKGRGLS LSRFSWGAEG 130 140 150 160 170 QKPGFGYGGR APDYKPAHKG LKGAQDAQGT LSKIFKLGGR DSRSGSPMAR R

References

[1]	"Amino acid sequence of porcine myelin basic protein." Kira J., Deibler G.E., Krutzsch H.C., Martenson R.E. J. Neurochem. 44:134-142(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, METHYLATION AT ARG-107. Tissue: Brain.
[2]	Erratum Kira J., Deibler G.E., Krutzsch H.C., Martenson R.E. J. Neurochem. 44:1663-1663(1985)

Cross-references

Sequence databases
PIR	MBPGB. A61640.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG008347.
Family and domain databases
InterPro	IPR000548. Myelin_BP. [Graphical view]
PANTHER	PTHR11429. PTHR11429. 1 hit.
Pfam	PF01669. Myelin_MBP. 1 hit. [Graphical view]
PRINTS	PR00212. MYELINMBP.
PROSITE	PS00569. MYELIN_MBP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MBP_PIG

Accession

Primary (citable) accession number: P81558
Secondary accession number(s): P98189

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program