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Protein

Defensin heliomicin

Gene
N/A
Organism
Heliothis virescens (Tobacco budworm moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This peptide has potent anti-fungal activity. Has no activity against Gram-negative and Gram-positive bacteria.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Defensin, Fungicide

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin heliomicin
OrganismiHeliothis virescens (Tobacco budworm moth)
Taxonomic identifieri7102 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHeliothis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000744771 – 44Defensin heliomicinAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 32
Disulfide bondi18 ↔ 40
Disulfide bondi22 ↔ 42

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi8 – 11Combined sources4
Helixi18 – 24Combined sources7
Beta strandi30 – 32Combined sources3
Beta strandi34 – 37Combined sources4
Beta strandi39 – 42Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I2UNMR-A1-44[»]
1I2VNMR-A1-44[»]
ProteinModelPortaliP81544.
SMRiP81544.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81544.

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 2 subfamily.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
DKLIGSCVWG AVNYTSDCNG ECKRRGYKGG HCGSFANVNC WCET
Length:44
Mass (Da):4,790
Last modified:May 30, 2000 - v1
Checksum:i301DA1BD3376FCD5
GO

Mass spectrometryi

Molecular mass is 4784.8 Da from positions 1 - 44. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I2UNMR-A1-44[»]
1I2VNMR-A1-44[»]
ProteinModelPortaliP81544.
SMRiP81544.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP81544.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFN_HELVI
AccessioniPrimary (citable) accession number: P81544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.