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P81534 (D103A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-defensin 103
Alternative name(s):
Beta-defensin 3
Short name=BD-3
Short name=DEFB-3
Short name=HBD3
Short name=hBD-3
Defensin, beta 103
Defensin-like protein
Gene names
Name:DEFB103A
Synonyms:BD3, DEFB103, DEFB3
AND
Name:DEFB103B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length67 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. Ref.1

Subcellular location

Secreted.

Tissue specificity

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. Ref.1

Induction

By bacterial infection and by IFNG/IFN-gamma. Ref.1

Sequence similarities

Belongs to the beta-defensin family.

Mass spectrometry

Molecular mass is 5154.59 Da from positions 23 - 67. Determined by ESI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Peptide23 – 6745Beta-defensin 103 Ref.1
PRO_0000006971

Amino acid modifications

Disulfide bond33 ↔ 62
Disulfide bond40 ↔ 55
Disulfide bond45 ↔ 63

Experimental info

Sequence conflict451C → R in AAM62424. Ref.6

Secondary structure

............ 67
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P81534 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 54266DE1C90D4B65

FASTA677,697
        10         20         30         40         50         60 
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE QIGKCSTRGR 


KCCRRKK 

« Hide

References

[1]"Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic."
Harder J., Bartels J., Christophers E., Schroeder J.-M.
J. Biol. Chem. 276:5707-5713(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-67, FUNCTION, TISSUE SPECIFICITY, INDUCTION, MASS SPECTROMETRY.
Tissue: Keratinocyte, Lung epithelium and Tracheal epithelium.
[2]"Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction."
Conejo-Garcia J.-R., Jaumann F., Schulz S., Krause A., Rodriguez-Jimenez F.-J., Forssmann U., Adermann K., Kluever E., Vogelmeier C., Becker D., Hedrich R., Forssmann W.-G., Bals R.
Cell Tissue Res. 306:257-264(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]"Discovery of new human beta-defensins using a genomics-based approach."
Jia H.P., Schutte B.C., Schudy A., Linzmeier R., Guthmiller J.M., Johnson G.K., Tack B.F., Mitros J.P., Rosenthal A., Ganz T., McCray P.B. Jr.
Gene 263:211-218(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]Imai Y.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"EST and genomic database mining yield novel human and mouse beta-defensins."
Adler D.A., Diamond G., Sheppard P., Holloway J., Presnell S., Jaspers S., Whitmore T., Fox B., Gosink J., Rixon M., Gao Z., Haldeman B., O'Hara P.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"Cloning and expression of Chinese human beta defensin-3."
Chen S., He F., Li R.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tonsil.
[7]"The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus."
Schibli D.J., Hunter H.N., Aseyev V., Starner T.D., Wiencek J.M., McCray P.B. Jr., Tack B.F., Vogel H.J.
J. Biol. Chem. 277:8279-8289(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 23-67.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ237673 mRNA. Translation: CAC03097.1.
AF295370 mRNA. Translation: AAG02237.1.
AF217245 mRNA. Translation: AAF73853.1.
AB037972 mRNA. Translation: BAB40572.1.
AF301470 mRNA. Translation: AAG22030.1.
AF516673 mRNA. Translation: AAM62424.1.
CCDSCCDS34810.1.
CCDS43701.1.
RefSeqNP_001075020.1. NM_001081551.3.
NP_061131.1. NM_018661.4.
UniGeneHs.283082.
Hs.637221.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KJ6NMR-A23-67[»]
ProteinModelPortalP81534.
SMRP81534. Positions 23-67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120984. 1 interaction.
STRING9606.ENSP00000320951.

Protein family/group databases

TCDB1.C.85.1.3. the pore-forming -defensin (-defensin) family.

Polymorphism databases

DMDM17372441.

Proteomic databases

PaxDbP81534.
PRIDEP81534.

Protocols and materials databases

DNASU414325.
55894.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314357; ENSP00000320951; ENSG00000176797.
ENST00000318124; ENSP00000324633; ENSG00000177243.
GeneID414325.
55894.
KEGGhsa:414325.
hsa:55894.
UCSCuc003wrf.3. human.

Organism-specific databases

CTD414325.
55894.
GeneCardsGC08M007277.
GC08P007739.
HGNCHGNC:15967. DEFB103A.
HGNC:31702. DEFB103B.
MIM606611. gene.
neXtProtNX_P81534.
PharmGKBPA134933952.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40430.
HOGENOMHOG000015465.
HOVERGENHBG004834.
InParanoidP81534.
OMASCLPREE.
OrthoDBEOG7SJD7S.
PhylomeDBP81534.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP81534.
CleanExHS_DEFB103A.
HS_DEFB103B.
GenevestigatorP81534.

Family and domain databases

InterProIPR001855. Defensin_beta-typ.
[Graphical view]
PfamPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP81534.
GeneWikiDEFB103A.
NextBio108587.
PROP81534.
SOURCESearch...

Entry information

Entry nameD103A_HUMAN
AccessionPrimary (citable) accession number: P81534
Secondary accession number(s): Q8NFG6, Q9NPF6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM