Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-defensin 103

Gene

DEFB103A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.1 Publication

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response to bacterium Source: MGI
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Protein family/group databases

TCDBi1.C.85.1.3 the pore-forming -defensin (-defensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 103
Alternative name(s):
Beta-defensin 3
Short name:
BD-3
Short name:
DEFB-3
Short name:
HBD3
Short name:
hBD-3
Defensin, beta 103
Defensin-like protein
Gene namesi
Name:DEFB103A
Synonyms:BD3, DEFB103, DEFB3
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000176797.3
HostDB:ENSG00000177243.3
HGNCiHGNC:15967 DEFB103A
HGNC:31702 DEFB103B
MIMi606611 gene
neXtProtiNX_P81534

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi414325
55894
OpenTargetsiENSG00000176797
PharmGKBiPA134933952

Polymorphism and mutation databases

BioMutaiDEFB103A
DMDMi17372441

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
PeptideiPRO_000000697123 – 67Beta-defensin 103Add BLAST45

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 62
Disulfide bondi40 ↔ 55
Disulfide bondi45 ↔ 63

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP81534
PeptideAtlasiP81534
PRIDEiP81534

Expressioni

Tissue specificityi

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.1 Publication

Inductioni

By bacterial infection and by IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000176797
CleanExiHS_DEFB103A
HS_DEFB103B
GenevisibleiP81534 HS

Interactioni

Protein-protein interaction databases

BioGridi120984, 1 interactor
IntActiP81534, 3 interactors
STRINGi9606.ENSP00000324633

Structurei

Secondary structure

167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni29 – 31Combined sources3
Helixi32 – 36Combined sources5
Beta strandi39 – 44Combined sources6
Beta strandi49 – 53Combined sources5
Beta strandi55 – 59Combined sources5
Beta strandi61 – 65Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJ6NMR-A23-67[»]
ProteinModelPortaliP81534
SMRiP81534
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81534

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFYR Eukaryota
ENOG411134U LUCA
GeneTreeiENSGT00530000064280
HOGENOMiHOG000015465
HOVERGENiHBG004834
InParanoidiP81534
OMAiIRGGRCA
OrthoDBiEOG093719AW
PhylomeDBiP81534

Family and domain databases

InterProiView protein in InterPro
IPR001855 Defensin_beta-typ
PfamiView protein in Pfam
PF00711 Defensin_beta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE
60
QIGKCSTRGR KCCRRKK
Length:67
Mass (Da):7,697
Last modified:June 1, 2001 - v2
Checksum:i54266DE1C90D4B65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45C → R in AAM62424 (Ref. 6) Curated1

Mass spectrometryi

Molecular mass is 5154.59 Da from positions 23 - 67. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237673 mRNA Translation: CAC03097.1
AF295370 mRNA Translation: AAG02237.1
AF217245 mRNA Translation: AAF73853.1
AB037972 mRNA Translation: BAB40572.1
AF301470 mRNA Translation: AAG22030.1
AF516673 mRNA Translation: AAM62424.1
CCDSiCCDS34810.1
CCDS43701.1
RefSeqiNP_001075020.1, NM_001081551.3
NP_061131.1, NM_018661.4
XP_016885681.1, XM_017030192.1
UniGeneiHs.283082
Hs.637221

Genome annotation databases

EnsembliENST00000314357; ENSP00000320951; ENSG00000176797
ENST00000318124; ENSP00000324633; ENSG00000177243
ENST00000613448; ENSP00000480773; ENSG00000273641
GeneIDi414325
55894
KEGGihsa:414325
hsa:55894
UCSCiuc003wrf.4 human

Similar proteinsi

Entry informationi

Entry nameiD103A_HUMAN
AccessioniPrimary (citable) accession number: P81534
Secondary accession number(s): Q8NFG6, Q9NPF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health