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Protein

Beta-defensin 103

Gene

DEFB103A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.1 Publication

GO - Biological processi

  • defense response to bacterium Source: MGI
  • innate immune response Source: Reactome
  • positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Protein family/group databases

TCDBi1.C.85.1.3. the pore-forming -defensin (-defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 103
Alternative name(s):
Beta-defensin 3
Short name:
BD-3
Short name:
DEFB-3
Short name:
HBD3
Short name:
hBD-3
Defensin, beta 103
Defensin-like protein
Gene namesi
Name:DEFB103A
Synonyms:BD3, DEFB103, DEFB3
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:15967. DEFB103A.
HGNC:31702. DEFB103B.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: MGI
  • Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933952.

Polymorphism and mutation databases

BioMutaiDEFB103A.
DMDMi17372441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Peptidei23 – 6745Beta-defensin 103PRO_0000006971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 62
Disulfide bondi40 ↔ 55
Disulfide bondi45 ↔ 63

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP81534.
PRIDEiP81534.

Expressioni

Tissue specificityi

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.1 Publication

Inductioni

By bacterial infection and by IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000176797.
CleanExiHS_DEFB103A.
HS_DEFB103B.
GenevisibleiP81534. HS.

Interactioni

Protein-protein interaction databases

BioGridi120984. 1 interaction.
STRINGi9606.ENSP00000324633.

Structurei

Secondary structure

1
67
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni29 – 313Combined sources
Helixi32 – 365Combined sources
Beta strandi39 – 446Combined sources
Beta strandi49 – 535Combined sources
Beta strandi55 – 595Combined sources
Beta strandi61 – 655Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KJ6NMR-A23-67[»]
ProteinModelPortaliP81534.
SMRiP81534. Positions 23-67.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81534.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFYR. Eukaryota.
ENOG411134U. LUCA.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiP81534.
OMAiIRGGRCA.
OrthoDBiEOG091G16TA.
PhylomeDBiP81534.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE
60
QIGKCSTRGR KCCRRKK
Length:67
Mass (Da):7,697
Last modified:June 1, 2001 - v2
Checksum:i54266DE1C90D4B65
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451C → R in AAM62424 (Ref. 6) Curated

Mass spectrometryi

Molecular mass is 5154.59 Da from positions 23 - 67. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237673 mRNA. Translation: CAC03097.1.
AF295370 mRNA. Translation: AAG02237.1.
AF217245 mRNA. Translation: AAF73853.1.
AB037972 mRNA. Translation: BAB40572.1.
AF301470 mRNA. Translation: AAG22030.1.
AF516673 mRNA. Translation: AAM62424.1.
CCDSiCCDS34810.1.
CCDS43701.1.
RefSeqiNP_001075020.1. NM_001081551.3.
NP_061131.1. NM_018661.4.
UniGeneiHs.283082.
Hs.637221.

Genome annotation databases

EnsembliENST00000314357; ENSP00000320951; ENSG00000176797.
ENST00000318124; ENSP00000324633; ENSG00000177243.
ENST00000613448; ENSP00000480773; ENSG00000273641.
GeneIDi414325.
55894.
KEGGihsa:414325.
hsa:55894.
UCSCiuc003wrf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237673 mRNA. Translation: CAC03097.1.
AF295370 mRNA. Translation: AAG02237.1.
AF217245 mRNA. Translation: AAF73853.1.
AB037972 mRNA. Translation: BAB40572.1.
AF301470 mRNA. Translation: AAG22030.1.
AF516673 mRNA. Translation: AAM62424.1.
CCDSiCCDS34810.1.
CCDS43701.1.
RefSeqiNP_001075020.1. NM_001081551.3.
NP_061131.1. NM_018661.4.
UniGeneiHs.283082.
Hs.637221.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KJ6NMR-A23-67[»]
ProteinModelPortaliP81534.
SMRiP81534. Positions 23-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120984. 1 interaction.
STRINGi9606.ENSP00000324633.

Protein family/group databases

TCDBi1.C.85.1.3. the pore-forming -defensin (-defensin) family.

Polymorphism and mutation databases

BioMutaiDEFB103A.
DMDMi17372441.

Proteomic databases

PaxDbiP81534.
PRIDEiP81534.

Protocols and materials databases

DNASUi414325.
55894.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314357; ENSP00000320951; ENSG00000176797.
ENST00000318124; ENSP00000324633; ENSG00000177243.
ENST00000613448; ENSP00000480773; ENSG00000273641.
GeneIDi414325.
55894.
KEGGihsa:414325.
hsa:55894.
UCSCiuc003wrf.4. human.

Organism-specific databases

CTDi414325.
55894.
GeneCardsiDEFB103A.
DEFB103B.
HGNCiHGNC:15967. DEFB103A.
HGNC:31702. DEFB103B.
MIMi606611. gene.
neXtProtiNX_P81534.
PharmGKBiPA134933952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFYR. Eukaryota.
ENOG411134U. LUCA.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiP81534.
OMAiIRGGRCA.
OrthoDBiEOG091G16TA.
PhylomeDBiP81534.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

EvolutionaryTraceiP81534.
GeneWikiiDEFB103A.
PROiP81534.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176797.
CleanExiHS_DEFB103A.
HS_DEFB103B.
GenevisibleiP81534. HS.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD103A_HUMAN
AccessioniPrimary (citable) accession number: P81534
Secondary accession number(s): Q8NFG6, Q9NPF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.