Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-defensin 103

Gene

DEFB103A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.1 Publication

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response to bacterium Source: MGI
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Protein family/group databases

TCDBi1.C.85.1.3. the pore-forming -defensin (-defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 103
Alternative name(s):
Beta-defensin 3
Short name:
BD-3
Short name:
DEFB-3
Short name:
HBD3
Short name:
hBD-3
Defensin, beta 103
Defensin-like protein
Gene namesi
Name:DEFB103A
Synonyms:BD3, DEFB103, DEFB3
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000176797.3.
HostDB:ENSG00000177243.3.
HGNCiHGNC:15967. DEFB103A.
HGNC:31702. DEFB103B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi414325.
55894.
OpenTargetsiENSG00000176797.
PharmGKBiPA134933952.

Polymorphism and mutation databases

BioMutaiDEFB103A.
DMDMi17372441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
PeptideiPRO_000000697123 – 67Beta-defensin 103Add BLAST45

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 62
Disulfide bondi40 ↔ 55
Disulfide bondi45 ↔ 63

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP81534.
PRIDEiP81534.

Expressioni

Tissue specificityi

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.1 Publication

Inductioni

By bacterial infection and by IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000176797.
CleanExiHS_DEFB103A.
HS_DEFB103B.
GenevisibleiP81534. HS.

Interactioni

Protein-protein interaction databases

BioGridi120984. 1 interactor.
IntActiP81534. 3 interactors.
STRINGi9606.ENSP00000324633.

Structurei

Secondary structure

167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni29 – 31Combined sources3
Helixi32 – 36Combined sources5
Beta strandi39 – 44Combined sources6
Beta strandi49 – 53Combined sources5
Beta strandi55 – 59Combined sources5
Beta strandi61 – 65Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJ6NMR-A23-67[»]
ProteinModelPortaliP81534.
SMRiP81534.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81534.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFYR. Eukaryota.
ENOG411134U. LUCA.
GeneTreeiENSGT00530000064280.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiP81534.
OMAiIRSGQCA.
OrthoDBiEOG093719AW.
PhylomeDBiP81534.

Family and domain databases

InterProiView protein in InterPro
IPR001855. Defensin_beta-typ.
PfamiView protein in Pfam
PF00711. Defensin_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE
60
QIGKCSTRGR KCCRRKK
Length:67
Mass (Da):7,697
Last modified:June 1, 2001 - v2
Checksum:i54266DE1C90D4B65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45C → R in AAM62424 (Ref. 6) Curated1

Mass spectrometryi

Molecular mass is 5154.59 Da from positions 23 - 67. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237673 mRNA. Translation: CAC03097.1.
AF295370 mRNA. Translation: AAG02237.1.
AF217245 mRNA. Translation: AAF73853.1.
AB037972 mRNA. Translation: BAB40572.1.
AF301470 mRNA. Translation: AAG22030.1.
AF516673 mRNA. Translation: AAM62424.1.
CCDSiCCDS34810.1.
CCDS43701.1.
RefSeqiNP_001075020.1. NM_001081551.3.
NP_061131.1. NM_018661.4.
XP_016885681.1. XM_017030192.1.
UniGeneiHs.283082.
Hs.637221.

Genome annotation databases

EnsembliENST00000314357; ENSP00000320951; ENSG00000176797.
ENST00000318124; ENSP00000324633; ENSG00000177243.
ENST00000613448; ENSP00000480773; ENSG00000273641.
GeneIDi414325.
55894.
KEGGihsa:414325.
hsa:55894.
UCSCiuc003wrf.4. human.

Similar proteinsi

Entry informationi

Entry nameiD103A_HUMAN
AccessioniPrimary (citable) accession number: P81534
Secondary accession number(s): Q8NFG6, Q9NPF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families