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P81534

- D103A_HUMAN

UniProt

P81534 - D103A_HUMAN

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Protein
Beta-defensin 103
Gene
DEFB103A, BD3, DEFB103, DEFB3
DEFB103B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.1 Publication

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
  2. innate immune response Source: Reactome
  3. positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Protein family/group databases

TCDBi1.C.85.1.3. the pore-forming -defensin (-defensin) family.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Beta-defensin 103
Alternative name(s):
Beta-defensin 3
Short name:
BD-3
Short name:
DEFB-3
Short name:
HBD3
Short name:
hBD-3
Defensin, beta 103
Defensin-like protein
Gene namesi
Synonyms:BD3, DEFB103, DEFB3
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8
HGNCiHGNC:15967. DEFB103A.
HGNC:31702. DEFB103B.

Subcellular locationi

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. extracellular region Source: Reactome

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 Publication
Add
BLAST
Peptidei23 – 6745Beta-defensin 1031 Publication
PRO_0000006971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 62
Disulfide bondi40 ↔ 55
Disulfide bondi45 ↔ 63

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP81534.
PRIDEiP81534.

Expressioni

Tissue specificityi

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.1 Publication

Inductioni

By bacterial infection and by IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiP81534.
CleanExiHS_DEFB103A.
HS_DEFB103B.
GenevestigatoriP81534.

Interactioni

Protein-protein interaction databases

BioGridi120984. 1 interaction.
STRINGi9606.ENSP00000320951.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni29 – 313
Helixi32 – 365
Beta strandi39 – 446
Beta strandi49 – 535
Beta strandi55 – 595
Beta strandi61 – 655

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KJ6NMR-A23-67[»]
ProteinModelPortaliP81534.
SMRiP81534. Positions 23-67.

Miscellaneous databases

EvolutionaryTraceiP81534.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40430.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiP81534.
OMAiSCLPREE.
OrthoDBiEOG7SJD7S.
PhylomeDBiP81534.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81534-1 [UniParc]FASTAAdd to Basket

« Hide

MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE   50
QIGKCSTRGR KCCRRKK 67
Length:67
Mass (Da):7,697
Last modified:June 1, 2001 - v2
Checksum:i54266DE1C90D4B65
GO

Mass spectrometryi

Molecular mass is 5154.59 Da from positions 23 - 67. Determined by ESI. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451C → R in AAM62424. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ237673 mRNA. Translation: CAC03097.1.
AF295370 mRNA. Translation: AAG02237.1.
AF217245 mRNA. Translation: AAF73853.1.
AB037972 mRNA. Translation: BAB40572.1.
AF301470 mRNA. Translation: AAG22030.1.
AF516673 mRNA. Translation: AAM62424.1.
CCDSiCCDS34810.1.
CCDS43701.1.
RefSeqiNP_001075020.1. NM_001081551.3.
NP_061131.1. NM_018661.4.
UniGeneiHs.283082.
Hs.637221.

Genome annotation databases

EnsembliENST00000314357; ENSP00000320951; ENSG00000176797.
ENST00000318124; ENSP00000324633; ENSG00000177243.
GeneIDi414325.
55894.
KEGGihsa:414325.
hsa:55894.
UCSCiuc003wrf.3. human.

Polymorphism databases

DMDMi17372441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ237673 mRNA. Translation: CAC03097.1 .
AF295370 mRNA. Translation: AAG02237.1 .
AF217245 mRNA. Translation: AAF73853.1 .
AB037972 mRNA. Translation: BAB40572.1 .
AF301470 mRNA. Translation: AAG22030.1 .
AF516673 mRNA. Translation: AAM62424.1 .
CCDSi CCDS34810.1.
CCDS43701.1.
RefSeqi NP_001075020.1. NM_001081551.3.
NP_061131.1. NM_018661.4.
UniGenei Hs.283082.
Hs.637221.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KJ6 NMR - A 23-67 [» ]
ProteinModelPortali P81534.
SMRi P81534. Positions 23-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120984. 1 interaction.
STRINGi 9606.ENSP00000320951.

Protein family/group databases

TCDBi 1.C.85.1.3. the pore-forming -defensin (-defensin) family.

Polymorphism databases

DMDMi 17372441.

Proteomic databases

PaxDbi P81534.
PRIDEi P81534.

Protocols and materials databases

DNASUi 414325.
55894.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314357 ; ENSP00000320951 ; ENSG00000176797 .
ENST00000318124 ; ENSP00000324633 ; ENSG00000177243 .
GeneIDi 414325.
55894.
KEGGi hsa:414325.
hsa:55894.
UCSCi uc003wrf.3. human.

Organism-specific databases

CTDi 414325.
55894.
GeneCardsi GC08M007277.
GC08P007739.
HGNCi HGNC:15967. DEFB103A.
HGNC:31702. DEFB103B.
MIMi 606611. gene.
neXtProti NX_P81534.
PharmGKBi PA134933952.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40430.
HOGENOMi HOG000015465.
HOVERGENi HBG004834.
InParanoidi P81534.
OMAi SCLPREE.
OrthoDBi EOG7SJD7S.
PhylomeDBi P81534.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

EvolutionaryTracei P81534.
GeneWikii DEFB103A.
NextBioi 108587.
PROi P81534.
SOURCEi Search...

Gene expression databases

Bgeei P81534.
CleanExi HS_DEFB103A.
HS_DEFB103B.
Genevestigatori P81534.

Family and domain databases

InterProi IPR001855. Defensin_beta-typ.
[Graphical view ]
Pfami PF00711. Defensin_beta. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic."
    Harder J., Bartels J., Christophers E., Schroeder J.-M.
    J. Biol. Chem. 276:5707-5713(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-67, FUNCTION, TISSUE SPECIFICITY, INDUCTION, MASS SPECTROMETRY.
    Tissue: Keratinocyte, Lung epithelium and Tracheal epithelium.
  2. "Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction."
    Conejo-Garcia J.-R., Jaumann F., Schulz S., Krause A., Rodriguez-Jimenez F.-J., Forssmann U., Adermann K., Kluever E., Vogelmeier C., Becker D., Hedrich R., Forssmann W.-G., Bals R.
    Cell Tissue Res. 306:257-264(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Imai Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "EST and genomic database mining yield novel human and mouse beta-defensins."
    Adler D.A., Diamond G., Sheppard P., Holloway J., Presnell S., Jaspers S., Whitmore T., Fox B., Gosink J., Rixon M., Gao Z., Haldeman B., O'Hara P.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Cloning and expression of Chinese human beta defensin-3."
    Chen S., He F., Li R.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tonsil.
  7. "The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus."
    Schibli D.J., Hunter H.N., Aseyev V., Starner T.D., Wiencek J.M., McCray P.B. Jr., Tack B.F., Vogel H.J.
    J. Biol. Chem. 277:8279-8289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 23-67.

Entry informationi

Entry nameiD103A_HUMAN
AccessioniPrimary (citable) accession number: P81534
Secondary accession number(s): Q8NFG6, Q9NPF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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