Reviewed, UniProtKB/Swiss-Prot P81530 (MIFH_TRIMR)

Names and origin

Protein names	Recommended name:     L-dopachrome-methyl ester tautomerase     EC=5.3.3.12 Alternative name(s):     Macrophage migration inhibitory factor homolog
Organism	Trichuris muris (Mouse whipworm)
Taxonomic identifier	70415 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Enoplea › Trichocephalida › Trichuridae › Trichuris

Protein attributes

Sequence length	19 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Tautomerization of the methyl ester of L-dopachrome.
Catalytic activity	L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
Induction	Inhibited by free fatty acids and haematin.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Molecular function	Cytokine Isomerase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW dopachrome isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›19	›19	L-dopachrome-methyl ester tautomerase		PRO_0000158075
Experimental info
	Non-terminal residue	19	1

Sequences

	Sequence		Length	Mass (Da)
	P81530-1 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: F7D70C81D12F1234	FASTA	19	2,058
	10 PIFTFASNVP ADTITGFFL

References

[1]

"Rapid purification and characterization of L-dopachrome-methyl-ester tautomerase (macrophage migration inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi." Pennock J.L., Behnke J.M., Bickle Q.D., Devaney E., Grencis R.K., Isaac R.E., Joshua G.W.P., Selkirk M.E., Zhang Y., Meyer D.J. Biochem. J. 335:495-498(1998) [PubMed: 9794786] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.3.3.12. 274317.
Family and domain databases
InterPro	IPR019829. Macrophage_inhib_fac_CS. [Graphical view]
PROSITE	PS01158. MIF. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MIFH_TRIMR

Accession

Primary (citable) accession number: P81530

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)